Vitality Pro
Vitality Pro
Cellular Health Longevity Heart Health

TMG

Methylation
  • TMG
  • TMG
  • TMG
  • TMG
  • TMG
    • TMG
    TMG
    TMG
    TMG
    TMG

    Third-Party Tested

    GMP Certified Facility

    ISO Quality Managed

    • Why Others Choose Vitality Pro

    TMG

    Methylation

    Trimethylglycine (TMG), also known as betaine, is a compound that supports methylation, altering molecular activity to help the body adapt to environmental changes and regulate essential processes.

    Features

    • 500mg per capsule
    • Take 1-2 per day
    • Suitable for vegans
    • Free from common allergens

    Quantity

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    • 5% off first 3 renewals
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    Third-Party Tested

    Date • Batch # • Results

    Purity results include Heavy Metals

    Current Batch:

    July 2026

    •

    2500552

    96% Purity and Microbiology

    Previous results:

    July 2025

    •

    2500299

    98% Purity and Microbiology

    December 2024

    •

    BN2400713

    95.1% Purity and Microbiology

    April 2024

    •

    BN262231006-2301376

    100% Purity and Microbiology

    December 2022

    •

    TMG12082022

    96.3% Purity

    December 2021

    •

    TMG11222021

    100% Purity

    GMP Certified Facility

    Our supplements are manufactured in the UK, at facilities in Oxford and the North of England, following Good Manufacturing Practice (GMP) standards.

    GMP sets requirements for hygiene, production, quality control, and traceability, helping ensure supplements are consistently manufactured under controlled conditions.

    Our manufacturing partners hold independently issued GMP certificates. Rather than simply asking you to take our word for it, we've made these available below for you to review.

    Our UK Manufacturers' GMP Certificates

    Issued by Eurofins and SGS.

    Manufacturer 1

    Manufacturer 2

    Manufacturer names have been redacted for commercial confidentiality.

    ISO Quality Managed

    Vitality Pro is independently certified to ISO 9001:2015, an internationally recognised standard for quality management systems.

    Maintaining this certification requires ongoing monitoring, documented checks, regular reporting and independent audits. These processes help identify areas for improvement, ensure issues are addressed, and continually strengthen the systems and controls behind our supplements. It's a commitment to quality that must be demonstrated and maintained, not simply claimed.

    We believe quality should be independently verified, not simply claimed. You can view our ISO 9001:2015 certificate below.

    Our ISO 9001:2015 Certificate

    View Our Certificate

    Recommended Use

    For general health and to support normal methylation take 1-2 capsules per day with water. TMG can be taken with or without food.

    To support exercise performance, take your TMG dosage 30 minutes before your training session with your normal pre-workout nutrition. This may result in an increase in cellular hydration as well as an increase in levels of a molecule called nitric oxide, which helps to open up blood vessels and allow more oxygen to be delivered to target muscles.

    Ingredients

    View supplement label

    Capsules Per Container: 120

    Amount Per Capsule Amount %NRV
    Trimethylglycine (TMG) 500mg *
    as Betaine Anhydrous

    Nutrient Reference Value not established*

    Other ingredients (all natural): Microcrystalline Cellulose, Rice Concentrate, Vegetable Cellulose Capsule (HPMC)

    Suitable for vegans. Contains no GMOs, common allergens, artificial colours, preservatives or flavours.

    Storage & Stability

    To maintain the potency and quality of your TMG supplements, store them in a cool (20°C-25°C), dry place and away from light.

    Quality Standards

    Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015. Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Micro Quality Labs. You can view all testing certificates at www.vitality-pro.com/batch-testing.

    Safety & Warnings

    Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.

    Interactions: There are no known published interactions between TMG and other medications at 10 November 2024. However, this does not mean interactions do not exist. TMG is used to lower levels of Homocysteine and may interfere with other similar medications. If you are taking these medications or any other medication, please first speak with your doctor before adding TMG to your supplement regime.

    For further information regarding any other potential drug and supplement interactions with TMG, please see the individual ingredient profiles on Drug Bank using the link below.* Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.

    Pregnancy: If pregnant, consult your health professional before using this product.

    *Drug Bank is an independent website that lists potential interactions between the ingredients in TMG and other medications and supplements. It may not, however, list all known possible interactions. If you are taking any medications or supplements that you feel may interact negatively with TMG, please speak with your doctor before using this product.
    1

    Key Studies to Consider

    While individual results may vary due to personal health conditions, genetics, and lifestyle choices, we guarantee that the supplements you receive are made with ingredients of the highest purity, similar to those used in scientific studies, to ensure maximum results.

    Methylation

    TMG (also known as betaine) supplies the body with methyl groups during methylation, supporting processes like DNA repair, gene regulation, and detoxification by converting homocysteine to methionine in the methylation cycle.

    Read more

    Heart Health

    Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women – Randomised Controlled Trial

    Dosage: Daily doses of 1.5, 3, and 6 grams of betaine for 6 weeks

    Outcome: Reduced levels of plasma homocysteine, which is associated with lower risk of heart disease

    Summary: Taking betaine was found to significantly lower the levels of homocysteine in the blood both immediately and over six weeks in healthy adults. This suggests that eating foods high in betaine or taking supplements could help reduce the risk of heart disease.

    Read more

     Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis – Meta-analysis

    Intervention: At least 4 g/day of betaine for 6 to 24 weeks

    Outcome: Reduction in plasma homocysteine levels by 1.23 μmol/L

    Summary: Betaine supplementation at a dose of at least 4g/day for a minimum of 6 weeks significantly lowers plasma homocysteine levels in healthy adults, which could contribute to heart protection.

    Read more

    Performance

    Effects of betaine on body composition, performance, and homocysteine thiolactone –  Randomised Controlled Trial

    Dosage: 2.5 grams of betaine daily for 6 weeks

    Outcome: Changes in body composition, arm size, bench press performance, and a marker in the urine related to heart health

    Summary: Betaine supplementation for 6 weeks helped improve body composition and arm size, increased bench press performance, and reduced a potentially harmful marker in the urine without significantly enhancing overall strength or power in experienced strength-trained men.

    Read more

    Effects of chronic betaine supplementation on performance in professional young soccer players during a competitive season – Randomised Controlled Trial

    Dosage: 2 grams of betaine (also known as TMG) daily for 14 weeks

    Outcome: Improvement in muscle strength, oxygen use during exercise, and ability to perform repeated sprints

    Summary: Giving young professional soccer players betaine every day for 14 weeks helped them get stronger, use oxygen better during exercise, and do repeated sprints more effectively compared to those who didn’t take betaine.

    Read more

    Effects of Short-Term Betaine Supplementation on Muscle Endurance and Hormone Levels After Intense Exercise in Young Athletes – Double-Blind, Crossover Study

    Dosage: 2.5 grams of betaine daily for 14 days

    Outcome: Increased muscle endurance, lower stress hormone levels, and higher testosterone levels after intense exercise

    Summary: Young handball players who took betaine for two weeks could do more repetitions in exercises and had better hormone levels indicating less stress and better muscle recovery compared to when they took a placebo.

    Read more

    Everything You Need To Know About TMG

    Trimethylglycine (TMG), also known as betaine, is a derivative of the amino acid glycine. It is found naturally in the body and in certain foods, such as beetroot, spinach, and whole grains. TMG supports methylation, a biochemical process essential for cellular function and adaptation to the body’s changing demands.

    TMG supports methylation by converting excess homocysteine into methionine. Through this process, TMG attaches a methyl group to homocysteine, forming methionine, which is then used to produce S-adenosylmethionine (SAMe), a key methyl donor which supports methylation by ensuring there are enough “methyl groups” to meet the body’s methylation demands.

    Methylation modifies DNA by adding methyl groups to specific molecules in the body, turning certain genes on or off, and ensuring essential functions like repair and growth are active while silencing unnecessary processes for cell stability. In detoxification, methylation transforms toxins into safer, water-soluble compounds that the liver can then expel from the body. For neurotransmitter production, SAMe donates methyl groups to create serotonin and dopamine building blocks, thereby aiding in their formation. Additionally, by donating methyl groups to creatine precursors, methylation helps to increase creatine availability, supporting energy demands during high-intensity exercise.

    Long-term NMN or NR use can deplete methyl groups because excess nicotinamide produced in the NMN-to-NAD cycle requires methylation for removal. This depletion might lead to fatigue in some individuals. TMG can help replenish these methyl groups, though it’s not necessary for everyone. If you experience fatigue with NMN or NR, it is recommended that you consider supplementing with TMG.

    Healthy methylation supports essential bodily functions by adding or removing chemical groups (methyl groups) to activate or silence genes as needed. This is required for cell growth, repair, and the regulation of cellular functions. In a simple sense, methyl groups can be considered the fuel for methylation.

    It is estimated that up to 70% of the population has a variant in the MTHFR gene, known as a polymorphism. The majority of these variants can lead to reduced methylation as they affect an enzyme essential for producing SAMe – the body’s primary methyl donor. Consult a healthcare professional if you have concerns about your MTHFR status.

    Research suggests that methylation capacity declines with age, leading to impaired cellular function, inefficient detoxification, and increased homocysteine levels, all of which are linked to age-related decline. Supporting optimal methylation activity and keeping homocysteine levels within a healthy range may help support long-term cellular health.

    Consider the statements below. If you find one or more relatable, TMG might be the supplement you’re looking for:

    • I wish to support a healthy cardiovascular system by managing homocysteine levels.
    • I take NAD precursors and fatigue is a constant battle for me. I seek to improve my energy levels for a more active lifestyle.
    • My healthcare provider mentioned the importance of supporting methylation processes for overall health.
    • I’m interested in supporting a healthy mood balance and I feel my methylation status is having an impact.
    • I have a reduction in MTHFR activity and wish to support healthy methylation.
    Made to GMP Standards
    ISO 9001 Certified UK Company
    Independent Testing for Purity

    Transparent Testing

    Every batch is independently tested for identity, potency, contaminants, heavy metals, and microbial markers.

    View all product tests

    TMG test results

    Date • Batch # • Results

    Purity results include Heavy Metals

    Current Batch:

    July 2026

    •

    2500552

    96% Purity and Microbiology

    Previous results:

    July 2025

    •

    2500299

    98% Purity and Microbiology

    December 2024

    •

    BN2400713

    95.1% Purity and Microbiology

    April 2024

    •

    BN262231006-2301376

    100% Purity and Microbiology

    December 2022

    •

    TMG12082022

    96.3% Purity

    December 2021

    •

    TMG11222021

    100% Purity

    Frequently Asked Questions

    This TMG supplement is Betaine Anhydrous and will not raise stomach acid.

    Yes, TMG is made in the body.

    TMG is naturally found in foods such as beets, broccoli, shellfish, and spinach. However, due to the low amounts present in food, a supplement is likely the best option to receive the full benefits of TMG.

    TMG supports methylation in the body. For some, TMG supplementation can lead to excess methylation, which can result in symptoms such as anxiety and fatigue. If you experience any of these symptoms, it is recommended that you stop taking TMG.

    Certainty of purity.

    We are committed to the following quality controls to ensure consistency, reliability, and transparency in every product. Our goal is to raise industry standards and give you clear reasons to trust what you’re taking.

  • GMP Certified Facility

    All products are made to cGMP (current Good Manufacturing Practice) standards, the global benchmark for supplement quality. GMP standards ensure strict control over how our supplements are produced, covering everything from cleanliness to documentation and quality control. Every step is monitored to guarantee consistency and safety in every batch, so you receive the same high-quality product every time.

  • Third-Party Tested

    At the foundation of what we offer is certainty of product quality through consistent third-party testing, specifically for purity.

  • ISO Quality Managed

    ISO 9001:2015 standards are an internationally recognised framework for effective quality management. This accreditation means we follow a structured system of continuous improvement, always refining our processes to enhance product consistency and customer satisfaction. ISO accreditation ensures that every aspect of our operations, from production to customer service, is optimised. This means better oversight, reduced risk of errors, and a clear focus on delivering consistent results.

  • Transparency

    We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.

    •

    GMP Certified Facility

    Our supplements are manufactured in the UK, at facilities in Oxford and the North of England, following Good Manufacturing Practice (GMP) standards.

    GMP sets requirements for hygiene, production, quality control, and traceability, helping ensure supplements are consistently manufactured under controlled conditions.

    Our manufacturing partners hold independently issued GMP certificates. Rather than simply asking you to take our word for it, we've made these available below for you to review.

    Our UK Manufacturers' GMP Certificates

    Issued by Eurofins and SGS.

    Manufacturer 1

    Manufacturer 2

    Manufacturer names have been redacted for commercial confidentiality.

    Third-Party Tested

    Date • Batch # • Results

    Purity results include Heavy Metals

    Current Batch:

    July 2026

    •

    2500552

    96% Purity and Microbiology

    Previous results:

    July 2025

    •

    2500299

    98% Purity and Microbiology

    December 2024

    •

    BN2400713

    95.1% Purity and Microbiology

    April 2024

    •

    BN262231006-2301376

    100% Purity and Microbiology

    December 2022

    •

    TMG12082022

    96.3% Purity

    December 2021

    •

    TMG11222021

    100% Purity

    ISO Quality Managed

    Vitality Pro is independently certified to ISO 9001:2015, an internationally recognised standard for quality management systems.

    Maintaining this certification requires ongoing monitoring, documented checks, regular reporting and independent audits. These processes help identify areas for improvement, ensure issues are addressed, and continually strengthen the systems and controls behind our supplements. It's a commitment to quality that must be demonstrated and maintained, not simply claimed.

    We believe quality should be independently verified, not simply claimed. You can view our ISO 9001:2015 certificate below.

    Our ISO 9001:2015 Certificate

    View Our Certificate

    Transparency

    We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.

    Transparency means we share all the details that matter—how our products are made, tested, and verified. From publishing third-party test results to offering clear ingredient labels, we provide you with the information you need to make informed choices about your supplements. Nothing is hidden, and every product comes with full accountability.

    In a world where many supplement companies keep you in the dark, we believe you deserve complete honesty. Being transparent allows you to trust that you’re getting exactly what you expect—pure, tested supplements without hidden risks. It’s about empowering you to make confident decisions and focus on your health journey without second-guessing the products you take.

    Trusted By Professionals & Industry Experts

  • Dr. Ahmet Ozyigit

    Dr. Ahmet Ozyigit, MD, MSc, PgDip

    Head of Clinical Research at Elite Hospital

    "As a physician, purity of a product is my main concern when it comes to recommending supplements for my patients. The line of products offered by vitalityPRO is not only in line with the latest research in anti-ageing, but is also third-party tested and purity checked, which is of utmost importance for receiving maximal benefits from treatment."

  • Simon Jones

    Simon Jones, MBChB, MRCP, MSc

    Lead Academy Doctor at a Premier League Football Club

    "Vitality Pro is a fantastic company, clearly striving to achieve the highest standard and reliability of supplements on the market. Their range really is at the cutting edge of longevity supplements, and the independent third-party testing is incredibly reassuring in terms of quality."

  • Casey Vincent

    Casey Vincent, Two-Time Olympian

    Australian Olympics Sprinter 2000-2004

    “I have done my research on vitalityPRO products and without a doubt have found their supplements to be far superior to the competition”

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    Tony Pemberton, FdENG

    Certified Epigenetic Coach

    "I'm very discerning of either overpriced supplements or poor quality ingredients, but I have to say Vitality PRO products are superb while still being great value. I use them myself for improving ageing biomarkers, and I am happy to recommend them to both my clients and viewership."

  • Kim Forteza

    Kim Forteza, MSc, PGCert, TPU, CNS

    Elite Athlete Coach

    "I have found Vitality Pro to have a great commitment to the client. They generate trust due to their service, presentation, formulation, technical explanations, and third-party analysis of each of their products. It is a brand that I always recommend when looking for excellence in a product, both for my athletes and for all people looking for supplementation with guarantees."

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    Emel Gunay, DipCNM, mBANT, mIFM

    Nutritional Therapist and Research Manager at OMNOS

    "V​itality-PRO offers excellent customer support, knowledgeable staff, and great value for money on high-quality supplements. ​​The products are of outstanding quality, and I appreciate their dedication to quality and transparency, which ensures safety and compliance for my clients. I​ can highly recommend ​them."

  • Jonny Hirtenstein

    Jonny Hirtenstein, MChiro, DC, ACN

    Founder and Lead Chiropractor at Foundation For Life

    ”As a clinician I appreciate Vitality Pro's passion for producing products that are designed to deliver great results and knowing that they independently test all the batches of the products is very reassuring. Ultimately I know that they care about everything they do, and are striving to produce some of the most cutting edge products on the market.”

  • Dr. Zain Khan

    Dr. Zain Khan, MBBS

    British Medical Association Executive Council Member

    “A professional supplement company who aim to be transparent, innovative and trustworthy. They invest time and money into conducting independent lab tests to verify the purity and quality of their products, ensuring that you receive precisely what you pay for.”

  • Dr James Hetfield

    Dr James Hetfield, Lead Doctor

    Lead Doctor

    Specialise in being a doctor

  • Andy Smith

    Andy Smith, PEMF Expert

    CEO of NewMed & Founder of CELLER8

    "Vitality Pro offers an impressive range of high-quality supplements, and their Magnesium Glycinate is my personal favourite. I love stacking it with my daily PEMF sessions as they complement each other perfectly for enhanced wellness. I trust Vitality Pro for reliable vitamins and supplements, and I’m always happy to recommend them to my customers!"

    •

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