Vitality Pro
Vitality Pro
Longevity Sleep Mood

Apigenin

Sleep
  • Apigenin
  • Apigenin
  • Apigenin
  • Apigenin
  • Apigenin
    • Apigenin
    Apigenin
    Apigenin
    Apigenin
    Apigenin

    Third-Party Tested

    GMP Certified Facility

    ISO Quality Managed

    • Why Others Choose Vitality Pro?

    Apigenin

    Sleep

    Apigenin is a natural flavonoid found in chamomile and parsley. It has been studied for its ability to regulate GABA, a calming brain neurochemical, and inhibit CD38, an enzyme that consumes NAD.

    Features

    • 100mg per capsule
    • Take 1-3 for sleep, or 2-4 as a CD38 inhibitor
    • Naturally derived from Grapefruit Peel
    • Suitable for vegans 
    • Free from common allergens

    Quantity

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    Third-Party Tested

    Date • Batch # • Results

    Purity results include Heavy Metals

    Current Batch:

    January 2026

    •

    2501432

    100% Purity and Microbiology and Glyphosate

    Previous results:

    July 2025

    •

    2500300

    97% Purity and Microbiology and 97% Purity

    January 2024

    •

    BN12192023

    100% Purity and Microbiology

    December 2023

    •

    BN12192023

    100% Purity and Microbiology

    October 2022

    •

    API10202022

    98.7% Purity

    June 2022

    •

    API06142022

    98% Purity

    April 2022

    •

    API03172022

    98% Purity

    Testing is carried out by Certified Labs (formerly Micro Quality Labs).

    GMP Certified Facility

    Our supplements are manufactured in the UK, at facilities in Oxford and the North of England, following Good Manufacturing Practice (GMP) standards.

    GMP sets requirements for hygiene, production, quality control, and traceability, helping ensure supplements are consistently manufactured under controlled conditions.

    Our manufacturing partners hold independently issued GMP certificates. Rather than simply asking you to take our word for it, we've made these available below for you to review.

    Our UK Manufacturers' GMP Certificates

    Issued by Eurofins and SGS.

    Manufacturer 1

    Manufacturer 2

    Manufacturer names have been redacted for commercial confidentiality.

    ISO Quality Managed

    Vitality Pro is independently certified to ISO 9001:2015, an internationally recognised standard for quality management systems.

    Maintaining this certification requires ongoing monitoring, documented checks, regular reporting and independent audits. These processes help identify areas for improvement, ensure issues are addressed, and continually strengthen the systems and controls behind our supplements. It's a commitment to quality that must be demonstrated and maintained, not simply claimed.

    We believe quality should be independently verified, not simply claimed. You can view our ISO 9001:2015 certificate below.

    Our ISO 9001:2015 Certificate

    View Our Certificate

    Recommended Use

    For sleep support, take 1-3 capsules 20-30 minutes before sleep. If your goal is to increase NAD levels by inhibiting the enzyme CD38, take 2-4 capsules per day before bed.

    Apigenin is fat-soluble, meaning it is best absorbed by the body when taken with a fat source. Healthy options for this are avocado, yoghurt, coconut or extra virgin olive oil.

    CD38 inhibitors are not recommended when fighting an active infection. CD38 helps regulate immune cell activity and promotes the production of important inflammatory molecules that control and eliminate pathogens.

    Ingredients

    View supplement label

    Capsules Per Container: 90

    Amount Per Capsule Amount %NRV
    Apigenin 100mg *
    from Grapefruit Peel, natural source

    Nutrient Reference Value not established*

    Other ingredients (all natural): Organic Brown Rice Flour, Vegetable Cellulose Capsule Shell (HPMC)

    Suitable for vegans. Contains no GMOs, common allergens, artificial colours, preservatives or flavours.

    Storage & Stability

    To maintain the potency and quality of your Apigenin store it in a cool (20°C-25°C), dry place and away from light.

    Quality Standards

    Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015. Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Micro Quality Labs. You can view all testing certificates at www.vitality-pro.com/batch-testing.

    Safety & Warnings

    Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.

    Interactions: Apigenin is known to interact with members of the Cytochrome P450 class of enzymes. As a result, it may interfere with antiplatelet and anticoagulant medications such as Warfarin and Aspirin. Because Apigenin has sedative properties, it might compound the effects of certain sedating medications such as Diazepam. It has also been shown to interact with certain chemotherapy agents and may interfere with the effectiveness of certain anti-anxiety medications such as Diazepam. In some people, Apgenin may act in a similar way to the hormone Oestrogen and, therefore, interfere with certain hormone replacement therapy interventions. If you are taking these medications or any other medication, please first speak with your doctor before adding Apigenin to your supplement regime.

    For further information regarding any other potential drug and supplement interactions with Apigenin, please see the ingredient profile on Drug Bank using the link below.* Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.

    Pregnancy: If pregnant, consult your health professional before using this product.

    *Drug Bank is an independent website that lists potential interactions between the ingredients in Apigenin and other medications and supplements. It may not, however, list all known possible interactions. If you are on any medications or supplements you feel may interact negatively with Apigenin please first speak with your doctor before using this product.
    1

    Key Studies to Consider

    While individual results may vary due to personal health conditions, genetics, and lifestyle choices, we guarantee that the supplements you receive are made with ingredients of the highest purity, similar to those used in scientific studies, to ensure maximum results.

    CD38 Inhibition

     Apigenin: a natural molecule at the intersection of sleep and aging – Review

    Outcome: Apigenin inhibits the enzyme CD38, which helps increase NAD+ levels, a molecule essential for healthy ageing.

    Summary: Apigenin inhibits CD38, preventing the consumption of NAD+ in cells, leading to higher NAD+ levels. This mechanism is linked to its potential anti-ageing benefits and improvement of cellular functions related to sleep and longevity.

    Read more

    Sleep

     Apigenin: a natural molecule at the intersection of sleep and aging – Review

    Dosage: N/A

    Outcome: Improved sleep quality through modulation of molecular pathways such as GABA and inflammation.

    Summary: Apigenin, a flavonoid found in chamomile, has shown potential to enhance sleep quality and influence ageing. It works by modulating sleep-related pathways and increasing NAD+ levels, with evidence from both animal and human studies suggesting a positive impact on sleep and mood.

    Read more

    The effects of chamomile extract on sleep quality among elderly people – Randomised Control Trial

    Dosage: 200 mg of chamomile extract, twice daily for 28 days

    Outcome: Improved sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI)

    Summary: Chamomile extract significantly improved sleep quality among elderly participants compared to the control group. This suggests chamomile can be a safe, natural remedy for improving sleep in older adults.

    Read more

    Cellular Health

     Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NAD CD38 Axis – Cell Study

    Dosage: NA

    Outcome: Reduced ageing signs in lung cells exposed to stress

    Summary: Apigenin showed potential in fighting ageing in lung cells by activating certain pathways that counteract stress and ageing effects, suggesting it could help with lung diseases related to ageing, like COPD.

    Read more

     Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38 – Cell Study and Mouse Study

    Dosage: Mixed doses administered in cell cultures and in obese mice

    Outcome: Increased NAD+ levels, improved glucose and fat metabolism

    Summary: Apigenin inhibits CD38, leading to higher NAD+ levels, which improves cellular health by enhancing metabolic functions.

    Read more

    Longevity

      CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD+/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats – Preclinical Animal study

    Dosage: 20 mg/kg for 5 days (animal dose equivalent)

    Outcome: Increased NAD+/NADH ratio and Sirt3 activity; reduced kidney damage and oxidative stress in diabetic rats.

    Summary: Apigenin, by inhibiting CD38, increases NAD+ levels and Sirt3 activity, helping to reduce kidney damage caused by oxidative stress in diabetic rats with diabetic kidney disease.

    Read more

     Flavonoid Apigenin is an Inhibitor of the NAD+ ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome – Preclinical Animal Study

    Dose: 100 mg/kg of body weight (animal dose equivalent)

    Outcome: Increased NAD+ levels, reduced protein acetylation, and improved glucose and lipid regulation in obese mice.

    Summary: Apigenin inhibits CD38, boosting NAD+ levels, which helps regulate metabolism and could be a potential treatment for metabolic syndrome.

    Read more

    Everything You Need To Know About Apigenin

    Apigenin is a flavonoid found in plants like chamomile and parsley. It has been used for centuries in traditional remedies for its anti-inflammatory and calming effects, often to reduce anxiety and support digestion. More recently, it has been studied for its role in preserving NAD levels and its potential to improve sleep and reduce oxidative stress.

    The enzyme CD38 consumes significant amounts of NAD in its role in immune signalling and inflammatory responses. Apigenin has been identified as a CD38 inhibitor, binding to CD38 and blocking its activity. This action helps control inflammatory responses and preserves NAD levels.

    Apigenin supports GABA by binding to GABA receptors, enhancing GABA’s calming effects in the nervous system. This interaction helps enhance GABA’s ability to reduce excessive neuronal firing, leading to a calming effect on the brain, which can promote relaxation and aid sleep.

    Some studies have shown that Apigenin can control the NF-kB pathway, which regulates inflammation, by binding to and blocking the activity of an enzyme (IKK) that starts the pathway. This stops NF-kB from entering the cell and activating genes that produce inflammatory molecules.

    NAD is essential for cellular energy production, supporting optimal cellular repair and stress response, and activating longevity-related enzymes like sirtuins. However, NAD levels decline with age, stress, poor diet, and metabolic dysfunction. This reduction impacts energy production, accelerates cellular damage, and reduces the body’s ability to repair itself.

    Healthy sleep is also essential for overall health. During sleep, the brain consolidates new information, aiding memory and learning, while the body repairs itself. Key hormones like melatonin and growth hormone are released, supporting detoxification, muscle growth, and the production of neurochemicals like dopamine and serotonin. However, modern life disrupts sleep with factors such as blue light, noise, and late-night eating, which increase stress and hinder the production of the neurochemicals needed for restful sleep.

    As we age, levels of chemicals that consume NAD increase while the body’s ability to produce NAD declines. By inhibiting the CD38 enzyme, apigenin may help preserve NAD levels necessary for maintaining cellular energy and function with age. Additionally, sleep quality often decreases as we get older. By increasing GABA, a calming neurotransmitter, Apigenin may reduce stress and improve sleep quality, both essential for minimising cellular damage.

    Apigenin is formulated to support cellular energy and sleep.

    Consider the following statements. If you find one or more relatable, Apigenin might be the product you’ve been searching for:

    • I’ve read that apigenin can help increase NAD+ levels by slowing the activity of CD38, and I’m interested in including it in my longevity protocol to support cellular health and vitality.
    • I have trouble sleeping and am searching for a natural alternative to sleep medications.
    • I want to support my body’s natural anti-inflammatory processes.
    • I’ve struggled to find a natural solution for managing anxiety and stress. I’m intrigued by apigenin’s potential to act as a mild sedative, promoting relaxation without the side effects of pharmaceuticals.
    • My healthcare professional recommended exploring natural compounds that support longevity and wellness, and apigenin came highly recommended.
    Made to GMP Standards
    ISO 9001 Certified UK Company
    Independent Testing for Purity

    Transparent Testing

    Every batch is independently tested for identity, potency, contaminants, heavy metals, and microbial markers.

    View all product tests

    Apigenin test results

    Date • Batch # • Results

    Purity results include Heavy Metals

    Current Batch:

    January 2026

    •

    2501432

    100% Purity and Microbiology and Glyphosate

    Previous results:

    July 2025

    •

    2500300

    97% Purity and Microbiology and 97% Purity

    January 2024

    •

    BN12192023

    100% Purity and Microbiology

    December 2023

    •

    BN12192023

    100% Purity and Microbiology

    October 2022

    •

    API10202022

    98.7% Purity

    June 2022

    •

    API06142022

    98% Purity

    April 2022

    •

    API03172022

    98% Purity

    Testing is carried out by Certified Labs (formerly Micro Quality Labs).

    Frequently Asked Questions

    Apigenin has been identified as a CD38 inhibitor, binding to CD38 and blocking its activity. The enzyme CD38 consumes significant amounts of NAD in its role in immune signalling and inflammatory responses. This action helps control excessive inflammatory responses and preserves NAD levels.

    Your Apigenin product is sourced from natural Grapefruit Peel extract.

    Apigenin may improve sleep quality by binding to receptors in the brain that correspond with sleep and sleepiness. Apigenin is found abundantly in chamomile tea, which is believed to explain its similarly sedative effect.

    Apigenin is considered safe for daily use over an extended period. However, if taking it for sleep, some individuals may develop a tolerance with prolonged use. We recommend taking a short break every few weeks to maintain maximum efficacy.

    Some research suggests that consistent use of apigenin may help lower elevated levels of cortisol. If you are concerned about high cortisol, we suggest that you speak to your doctor before taking apigenin.

    Certainty of purity.

    We are committed to the following quality controls to ensure consistency, reliability, and transparency in every product. Our goal is to raise industry standards and give you clear reasons to trust what you’re taking.

  • GMP Certified Facility

    All products are made to cGMP (current Good Manufacturing Practice) standards, the global benchmark for supplement quality. GMP standards ensure strict control over how our supplements are produced, covering everything from cleanliness to documentation and quality control. Every step is monitored to guarantee consistency and safety in every batch, so you receive the same high-quality product every time.

  • Third-Party Tested

    At the foundation of what we offer is certainty of product quality through consistent third-party testing, specifically for purity.

  • ISO Quality Managed

    ISO 9001:2015 standards are an internationally recognised framework for effective quality management. This accreditation means we follow a structured system of continuous improvement, always refining our processes to enhance product consistency and customer satisfaction. ISO accreditation ensures that every aspect of our operations, from production to customer service, is optimised. This means better oversight, reduced risk of errors, and a clear focus on delivering consistent results.

  • Transparency

    We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.

    •

    GMP Certified Facility

    Our supplements are manufactured in the UK, at facilities in Oxford and the North of England, following Good Manufacturing Practice (GMP) standards.

    GMP sets requirements for hygiene, production, quality control, and traceability, helping ensure supplements are consistently manufactured under controlled conditions.

    Our manufacturing partners hold independently issued GMP certificates. Rather than simply asking you to take our word for it, we've made these available below for you to review.

    Our UK Manufacturers' GMP Certificates

    Issued by Eurofins and SGS.

    Manufacturer 1

    Manufacturer 2

    Manufacturer names have been redacted for commercial confidentiality.

    Third-Party Tested

    Date • Batch # • Results

    Purity results include Heavy Metals

    Current Batch:

    January 2026

    •

    2501432

    100% Purity and Microbiology and Glyphosate

    Previous results:

    July 2025

    •

    2500300

    97% Purity and Microbiology and 97% Purity

    January 2024

    •

    BN12192023

    100% Purity and Microbiology

    December 2023

    •

    BN12192023

    100% Purity and Microbiology

    October 2022

    •

    API10202022

    98.7% Purity

    June 2022

    •

    API06142022

    98% Purity

    April 2022

    •

    API03172022

    98% Purity

    Testing is carried out by Certified Labs (formerly Micro Quality Labs).

    ISO Quality Managed

    Vitality Pro is independently certified to ISO 9001:2015, an internationally recognised standard for quality management systems.

    Maintaining this certification requires ongoing monitoring, documented checks, regular reporting and independent audits. These processes help identify areas for improvement, ensure issues are addressed, and continually strengthen the systems and controls behind our supplements. It's a commitment to quality that must be demonstrated and maintained, not simply claimed.

    We believe quality should be independently verified, not simply claimed. You can view our ISO 9001:2015 certificate below.

    Our ISO 9001:2015 Certificate

    View Our Certificate

    Transparency

    We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.

    Transparency means we share all the details that matter—how our products are made, tested, and verified. From publishing third-party test results to offering clear ingredient labels, we provide you with the information you need to make informed choices about your supplements. Nothing is hidden, and every product comes with full accountability.

    In a world where many supplement companies keep you in the dark, we believe you deserve complete honesty. Being transparent allows you to trust that you’re getting exactly what you expect—pure, tested supplements without hidden risks. It’s about empowering you to make confident decisions and focus on your health journey without second-guessing the products you take.

    Trusted By Professionals & Industry Experts

  • Dr. Ahmet Ozyigit

    Dr. Ahmet Ozyigit, MD, MSc, PgDip

    Head of Clinical Research at Elite Hospital

    "As a physician, purity of a product is my main concern when it comes to recommending supplements for my patients. The line of products offered by vitalityPRO is not only in line with the latest research in anti-ageing, but is also third-party tested and purity checked, which is of utmost importance for receiving maximal benefits from treatment."

  • Simon Jones

    Simon Jones, MBChB, MRCP, MSc

    Lead Academy Doctor at a Premier League Football Club

    "Vitality Pro is a fantastic company, clearly striving to achieve the highest standard and reliability of supplements on the market. Their range really is at the cutting edge of longevity supplements, and the independent third-party testing is incredibly reassuring in terms of quality."

  • Casey Vincent

    Casey Vincent, Two-Time Olympian

    Australian Olympics Sprinter 2000-2004

    “I have done my research on vitalityPRO products and without a doubt have found their supplements to be far superior to the competition”

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    Tony Pemberton, FdENG

    Certified Epigenetic Coach

    "I'm very discerning of either overpriced supplements or poor quality ingredients, but I have to say Vitality PRO products are superb while still being great value. I use them myself for improving ageing biomarkers, and I am happy to recommend them to both my clients and viewership."

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    Elite Athlete Coach

    "I have found Vitality Pro to have a great commitment to the client. They generate trust due to their service, presentation, formulation, technical explanations, and third-party analysis of each of their products. It is a brand that I always recommend when looking for excellence in a product, both for my athletes and for all people looking for supplementation with guarantees."

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    Emel Gunay, DipCNM, mBANT, mIFM

    Nutritional Therapist and Research Manager at OMNOS

    "V​itality-PRO offers excellent customer support, knowledgeable staff, and great value for money on high-quality supplements. ​​The products are of outstanding quality, and I appreciate their dedication to quality and transparency, which ensures safety and compliance for my clients. I​ can highly recommend ​them."

  • Dr. Zain Khan

    Dr. Zain Khan, MBBS

    British Medical Association Executive Council Member

    “A professional supplement company who aim to be transparent, innovative and trustworthy. They invest time and money into conducting independent lab tests to verify the purity and quality of their products, ensuring that you receive precisely what you pay for.”

  • Jonny Hirtenstein

    Jonny Hirtenstein, MChiro, DC, ACN

    Founder and Lead Chiropractor at Foundation For Life

    ”As a clinician I appreciate Vitality Pro's passion for producing products that are designed to deliver great results and knowing that they independently test all the batches of the products is very reassuring. Ultimately I know that they care about everything they do, and are striving to produce some of the most cutting edge products on the market.”

  • Andy Smith

    Andy Smith, PEMF Expert

    CEO of NewMed & Founder of CELLER8

    "Vitality Pro offers an impressive range of high-quality supplements, and their Magnesium Glycinate is my personal favourite. I love stacking it with my daily PEMF sessions as they complement each other perfectly for enhanced wellness. I trust Vitality Pro for reliable vitamins and supplements, and I’m always happy to recommend them to my customers!"

    •

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