Vitality Pro
Vitality Pro
Cellular Health Longevity Antioxidant

Trans Resveratrol

Sirtuin Activator
  • Trans Resveratrol
  • Trans Resveratrol
  • Trans Resveratrol
  • Trans Resveratrol
  • Trans Resveratrol
  • Trans Resveratrol
  • Trans Resveratrol
    • Trans Resveratrol
    Trans Resveratrol
    Trans Resveratrol
    Trans Resveratrol
    Trans Resveratrol
    Trans Resveratrol
    Trans Resveratrol

    Third-Party Tested

    GMP Certified Facility

    ISO Quality Managed

    • Why Others Choose Vitality Pro?

    Trans Resveratrol

    Sirtuin Activator

    Resveratrol is a natural plant compound that acts as an antioxidant and is believed to activate sirtuins, which are responsible for activities linked to longevity, such as DNA repair, stress response, and metabolism.

    Features

    • 500mg per capsule
    • Take 1-2 capsules per day
    • Trans Resveratrol is the active form of Resveratrol that contributes to cellular health
    • Pure fill capsules, containing no fillers
    • Suitable for vegans
    • Free from common allergens

    Quantity

    The longer you subscribe, the more you save.

    • Skip, edit or cancel anytime
    • 5% off first 3 renewals
    • 10% off renewals 4-8
    • 15% off from renewal 9+

    Delivery every

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    Third-Party Tested

    Date • Batch # • Results

    Purity results include Heavy Metals

    Current Batch:

    March 2026

    •

    2600062

    99.9% Purity and Microbiology

    Previous results:

    April 2025

    •

    2401070

    99.2% Purity and Microbiology

    September 2024

    •

    BN08132024

    99.5% Purity and Microbiology

    December 2023

    •

    T-RES12042023

    99% Purity

    September 2023

    •

    T-RES09062023

    99.9% Purity

    May 2023

    •

    T-RES04202023

    99% Purity

    December 2022

    •

    T-RES12082022

    98% Purity

    May 2022

    •

    T-RES05022022

    100% Purity

    November 2021

    •

    T-RES10212021

    99% Purity

    March 2021

    •

    T-RES03042021

    99.5% Purity

    December 2019

    •

    T-RES11252019

    99.6% Purity

    GMP Certified Facility

    Our supplements are manufactured in the UK, at facilities in Oxford and the North of England, following Good Manufacturing Practice (GMP) standards.

    GMP sets requirements for hygiene, production, quality control, and traceability, helping ensure supplements are consistently manufactured under controlled conditions.

    Our manufacturing partners hold independently issued GMP certificates. Rather than simply asking you to take our word for it, we've made these available below for you to review.

    Our UK Manufacturers' GMP Certificates

    Issued by Eurofins and SGS.

    Manufacturer 1

    Manufacturer 2

    Manufacturer names have been redacted for commercial confidentiality.

    ISO Quality Managed

    Vitality Pro is independently certified to ISO 9001:2015, an internationally recognised standard for quality management systems.

    Maintaining this certification requires ongoing monitoring, documented checks, regular reporting and independent audits. These processes help identify areas for improvement, ensure issues are addressed, and continually strengthen the systems and controls behind our supplements. It's a commitment to quality that must be demonstrated and maintained, not simply claimed.

    We believe quality should be independently verified, not simply claimed. You can view our ISO 9001:2015 certificate below.

    Our ISO 9001:2015 Certificate

    View Our Certificate

    Recommended Use

    Take either 1 or 2 capsules per day in the morning with a healthy, high-fat meal. This is equal to either 500mg or 1000mg of Trans-Resveratrol.

    Trans-Resveratrol is fat-soluble, meaning it is best absorbed by the body when taken with a fat source. Healthy options for this are avocado, yoghurt, coconut or extra virgin olive oil.

    Ingredients

    View supplement label

    Capsules Per Container: 90

    Amount Per Capsule Amount %NRV
    Trans Resveratrol 500mg *
    from Japanese Knotweed, natural source

    Nutrient Reference Value not established*

    Other Ingredients (all natural) : Vegetable Cellulose Capsule (HPMC)

    Suitable for vegans. Contains no fillers, GMOs, common allergens, artificial colours, preservatives or flavours.

    Storage & Stability

    To maintain the potency and quality of your Resveratrol supplements, store them in a cool (20°C-25°C), dry place, and away from light. Trans-Resveratrol must not be exposed to light for long periods as it will degrade to Cis-Resveratrol. Please store your Resveratrol in a dark environment.

    Quality Standards

    Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015. Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Micro Quality Labs. You can view all testing certificates at www.vitality-pro.com/batch-testing.

    Safety & Warnings

    Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.

    Interactions: Trans-Resveratrol is known to inhibit members of the Cytochrome P450 class of enzymes. As a result, it may interfere with antiplatelet and anticoagulant medications such as Warfarin. Additionally, resveratrol is classed as a phytoestrogen, a plant molecule that can mimic the effects of oestrogen in the body. Therefore, individuals who are hormone replacement therapies should therefore consult with their doctors before adding resveratrol to their longevity protocols. If you are taking these medications or any other medication, please first speak with your doctor before adding Resveratrol to your supplement regime.

    For further information regarding any other potential drug and supplement interactions of Trans-Resveratrol please see the ingredient profile on Drug Bank.* Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.

    Pregnancy: If pregnant, consult your health professional before using this product.

    *Drug Bank is an independent website that lists potential interactions between the ingredients in Trans-Resveratrol and other medications and supplements. It may not, however, list all known possible interactions. If you are on any medications or supplements you feel may interact negatively with Trans-Resveratrol please first speak with your doctor before using this product.
    1

    Key studies to consider

    While individual results may vary due to personal health conditions, genetics, and lifestyle choices, we guarantee that the supplements you receive are made with ingredients of the highest purity, similar to those used in scientific studies, to ensure maximum results.

    Sirtuin Activator

    *The below research, carried out by Dr David Sinclair and others, suggests that Resveratrol may enhance the activity of SIRT1 through several mechanisms, such as mimicking the effects of caloric restriction. The pathways and the extent of how effectively Resveratrol can activate SIRT1 remain a topic of ongoing investigation.

     Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan – Cell Study

    Dosage: Not specified

    Outcome: Increased lifespan and DNA stability in yeast

    Summary: Resveratrol, which boosts NAD+ and activates sirtuins, extended the lifespan of yeast cells by 70%, similar to the effects of calorie restriction. This suggests that NAD+ and sirtuin activation could promote longevity.

    Read more

     The Role and Mechanism of SIRT1 in Resveratrol-regulated Osteoblast Autophagy in Osteoporosis Rats – Animal study

    Dosage: 5 mg/kg/day and 45 mg/kg/day resveratrol for 8 weeks

    Outcome: Resveratrol improved bone density and promoted autophagy in bone cells through SIRT1 activation.

    Summary: High-dose resveratrol activated SIRT1 and enhanced mitophagy in osteoblasts, protecting against bone loss in osteoporosis rats.

    Read more

    Longevity

    *Sirtuin 1 is a molecule that when activated has been shown to increase lifespan in both cell and mouse studies. While Resveratrol is believed to work by activating this molecule there is still debate in the longevity community about its efficacy of this.

    Resveratrol Improves Health and Survival of Mice on a High-Calorie Diet – Preclinical Animal Study

    Dosage: Resveratrol (dosage not specified)

    Outcome: Increased lifespan and improved health markers in mice fed a high-calorie diet

    Summary: In middle-aged mice, resveratrol improved general health and increased lifespan, mimicking the benefits of a standard diet. This was noted through several markers including better insulin sensitivity, lower levels of certain ageing-related factors, more mitochondria (energy-producing structures in cells) and enhanced physical ability.

    Read more

    Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan – Cell Study

    Dosage: Resveratrol, a compound found in red wine

    Outcome: Extended lifespan of yeast by 70%

    Summary: The study found that resveratrol can mimic the effects of eating less food to slow down ageing, leading to a significant increase in the lifespan of yeast. This suggests the potential benefits of resveratrol in promoting health and longevity.

    Read more

    Antioxidant

     Antioxidant effects of resveratrol in the cardiovascular system– Review

    Outcome: Resveratrol acts as an indirect antioxidant by regulating genes, reducing ROS production, and up-regulating antioxidant enzymes.

    Summary: Resveratrol appears to provide cardiovascular benefits mainly through its role as a gene regulator, decreasing ROS generation in mitochondria , rather than directly scavenging free radicals.

    Read more

     Antioxidant Effects of Resveratrol in Intervertebral Disk Degeneration – Review

    Outcome: Resveratrol reduces oxidative stress by scavenging free radicals and supporting mitochondrial function.

    Summary: Resveratrol acts as an antioxidant by reducing reactive oxygen species, which may slow the progression of intervertebral disk degeneration.

    Read more

    Inflammation

    The Role of Resveratrol on Rheumatoid Arthritis: From Bench to Bedside – Review

    Outcome: The study assesses the potential benefits of resveratrol, a natural compound found in grapes and red wine, in treating rheumatoid arthritis (RA) by targeting inflammation and immune responses.

    Summary: Resveratrol, known for its antioxidant properties, may help treat rheumatoid arthritis by reducing inflammation and protecting joints. Research suggests it could complement existing RA treatments, though more studies are needed to confirm its effectiveness and determine optimal dosages.

    Read more

    Effect of Resveratrol Supplementation on Inflammatory Markers – A Systematic Review and Meta-analysis of Randomised Controlled Trials

    Dosage: Mixed

    Outcome: Reduction in levels of TNF-α and hs-CRP, two markers of inflammation

    Summary: This study found that taking resveratrol can help lower certain signs of inflammation in the body. This suggests resveratrol might be useful alongside other treatments for diseases linked to inflammation.

    Read more

    Everything You Need To Know About Trans Resveratrol

    Resveratrol is a natural plant molecule known as a flavonoid, found in red wine, the skin of grapes, berries and other plants including Japanese Knotweed, a common supplement source. Plants produce resveratrol in response to stress, injury, or pathogens as part of their defence mechanism.

    Resveratrol comes in two forms: cis and trans, with trans-resveratrol being more biologically active due to its structure, which allows better interaction with enzymes and receptors. This makes trans-resveratrol more effective and widely studied for its health benefits.

    Some research has shown resveratrol to activate sirtuins, a group of proteins (notably SIRT1) involved in maintaining cellular health, most linked to longevity, such as DNA repair, metabolism, and stress response. SIRT1 specifically is shown to increase the number of mitochondria (the power plants) in the cell. Research suggests resveratrol influences sirtuin activity by enhancing the binding of NAD+ to sirtuins, powering their function. Resveratrol is also believed to activate AMPK, responsible for maintaining cellular energy balance, by mimicking a low-energy state in cells, similar to fasting. This activates AMPK, which works to increase cellular energy including activating SIRT1.

    As an antioxidant, resveratrol can directly neutralise reactive oxygen species (ROS) by donating electrons, thereby stabilising them. It has also been shown to influence the Nrf2 pathway by interfering with proteins that normally stops its activation. Nrf2 triggers the expression of various antioxidant and detoxification genes, such as those involved in glutathione production – the body’s master antioxidant.

    Healthy sirtuin activity ensures proper cellular metabolism, DNA repair, and stress response, while effective antioxidant pathways reduce oxidative damage, preserving cellular function. Over time, sirtuin activity and antioxidant defences can decline due to reduced NAD levels, poor diet, chronic stress, and exposure to environmental toxins. Reduced sirtuin activity and antioxidant defences weaken cellular repair and reduce cellular function and protection. These decreased defences increase oxidative stress and elevate reactive oxygen species (ROS) levels, overwhelming the cell’s antioxidant defences and triggering chronic inflammation, DNA damage, and accelerated cellular decline.

    Around middle age (40–50 years), a decline in metabolism and overall cellular health can lead to reduced sirtuin activity and antioxidant responses. Supporting these functions can maintain mobility by protecting muscle and joint function, promote cognitive health by reducing neuroinflammation, and help preserve overall cellular health, contributing to prolonged independence and resilience as we age.

    Consider the following statements. If any of them resonate with you, resveratrol might be the supplement you’re looking for.

    • I want to support my healthy ageing and longevity.
    • Antioxidant support is important to me. I want to protect my cells from damage caused by free radicals.
    • I’m interested in the potential of activating sirtuins and AMPK.
    • Managing healthy inflammation levels is important to me. I seek natural ways to support this balance.
    • My health care professional recommended resveratrol.
    Made to GMP Standards
    ISO 9001 Certified UK Company
    Independent Testing for Purity

    Transparent Testing

    Every batch is independently tested for identity, potency, contaminants, heavy metals, and microbial markers.

    View all product tests

    Trans Resveratrol test results

    Date • Batch # • Results

    Purity results include Heavy Metals

    Current Batch:

    March 2026

    •

    2600062

    99.9% Purity and Microbiology

    Previous results:

    April 2025

    •

    2401070

    99.2% Purity and Microbiology

    September 2024

    •

    BN08132024

    99.5% Purity and Microbiology

    December 2023

    •

    T-RES12042023

    99% Purity

    September 2023

    •

    T-RES09062023

    99.9% Purity

    May 2023

    •

    T-RES04202023

    99% Purity

    December 2022

    •

    T-RES12082022

    98% Purity

    May 2022

    •

    T-RES05022022

    100% Purity

    November 2021

    •

    T-RES10212021

    99% Purity

    March 2021

    •

    T-RES03042021

    99.5% Purity

    December 2019

    •

    T-RES11252019

    99.6% Purity

    Frequently Asked Questions

    Some research has shown resveratrol to activate sirtuins, a group of proteins (notably SIRT1) involved in maintaining cellular health, most linked to longevity, such as DNA repair, metabolism, and stress response. SIRT1 specifically is shown to increase the number of mitochondria (the power plants) in the cell.

    Research suggests resveratrol influences sirtuin activity by enhancing the binding of NAD+ to sirtuins, powering their function. Resveratrol is also believed to activate AMPK, responsible for maintaining cellular energy balance, by mimicking a low-energy state in cells, similar to fasting. This activates AMPK, which works to increase cellular energy including activating SIRT1.

    However, the extent of how effectively Resveratrol can activate SIRT1 remain a topic of ongoing debate.

    Olive oil, avocados and grass-finished dairy products such as yoghurt are examples of healthy fats you can take Resveratrol with.

    Resveratrol is classified as a phytoestrogen—a plant-derived compound that can interact with estrogen receptors—but it does not directly increase circulating estrogen levels. Instead, resveratrol acts as a selective estrogen receptor modulator (SERM), meaning it can both mimic and block estrogen’s effects depending on the context. For example, resveratrol can bind to estrogen receptors and may trigger estrogen-like responses in some tissues while competing with natural estrogen in others. Its overall impact depends on factors such as dosage, the individual’s hormonal environment, and the specific tissues involved. Thus, rather than boosting estrogen levels per se, resveratrol modulates estrogen signaling in a nuanced, context-dependent manner.

    Resveratrol exists in two forms: cis and trans. The trans form is more biologically active because its structure interacts more effectively with enzymes and receptors in the body. This makes trans-resveratrol more biologically active and the primary focus in research studies.

    Certainty of purity.

    We are committed to the following quality controls to ensure consistency, reliability, and transparency in every product. Our goal is to raise industry standards and give you clear reasons to trust what you’re taking.

  • GMP Certified Facility

    All products are made to cGMP (current Good Manufacturing Practice) standards, the global benchmark for supplement quality. GMP standards ensure strict control over how our supplements are produced, covering everything from cleanliness to documentation and quality control. Every step is monitored to guarantee consistency and safety in every batch, so you receive the same high-quality product every time.

  • Third-Party Tested

    At the foundation of what we offer is certainty of product quality through consistent third-party testing, specifically for purity.

  • ISO Quality Managed

    ISO 9001:2015 standards are an internationally recognised framework for effective quality management. This accreditation means we follow a structured system of continuous improvement, always refining our processes to enhance product consistency and customer satisfaction. ISO accreditation ensures that every aspect of our operations, from production to customer service, is optimised. This means better oversight, reduced risk of errors, and a clear focus on delivering consistent results.

  • Transparency

    We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.

    •

    GMP Certified Facility

    Droplets

    Our supplements are manufactured in the UK, at facilities in Oxford and the North of England, following Good Manufacturing Practice (GMP) standards.

    GMP sets requirements for hygiene, production, quality control, and traceability, helping ensure supplements are consistently manufactured under controlled conditions.

    Our manufacturing partners hold independently issued GMP certificates. Rather than simply asking you to take our word for it, we've made these available below for you to review.

    Our UK Manufacturers' GMP Certificates

    Issued by Eurofins and SGS.

    Manufacturer 1

    Manufacturer 2

    Manufacturer names have been redacted for commercial confidentiality.

    Third-Party Tested

    Date • Batch # • Results

    Purity results include Heavy Metals

    Current Batch:

    March 2026

    •

    2600062

    99.9% Purity and Microbiology

    Previous results:

    April 2025

    •

    2401070

    99.2% Purity and Microbiology

    September 2024

    •

    BN08132024

    99.5% Purity and Microbiology

    December 2023

    •

    T-RES12042023

    99% Purity

    September 2023

    •

    T-RES09062023

    99.9% Purity

    May 2023

    •

    T-RES04202023

    99% Purity

    December 2022

    •

    T-RES12082022

    98% Purity

    May 2022

    •

    T-RES05022022

    100% Purity

    November 2021

    •

    T-RES10212021

    99% Purity

    March 2021

    •

    T-RES03042021

    99.5% Purity

    December 2019

    •

    T-RES11252019

    99.6% Purity

    ISO Quality Managed

    Vitality Pro is independently certified to ISO 9001:2015, an internationally recognised standard for quality management systems.

    Maintaining this certification requires ongoing monitoring, documented checks, regular reporting and independent audits. These processes help identify areas for improvement, ensure issues are addressed, and continually strengthen the systems and controls behind our supplements. It's a commitment to quality that must be demonstrated and maintained, not simply claimed.

    We believe quality should be independently verified, not simply claimed. You can view our ISO 9001:2015 certificate below.

    Our ISO 9001:2015 Certificate

    View Our Certificate

    Transparency

    We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.

    Transparency means we share all the details that matter—how our products are made, tested, and verified. From publishing third-party test results to offering clear ingredient labels, we provide you with the information you need to make informed choices about your supplements. Nothing is hidden, and every product comes with full accountability.

    In a world where many supplement companies keep you in the dark, we believe you deserve complete honesty. Being transparent allows you to trust that you’re getting exactly what you expect—pure, tested supplements without hidden risks. It’s about empowering you to make confident decisions and focus on your health journey without second-guessing the products you take.

    Trusted By Professionals & Industry Experts

  • Dr. Ahmet Ozyigit

    Dr. Ahmet Ozyigit, MD, MSc, PgDip

    Head of Clinical Research at Elite Hospital

    "As a physician, purity of a product is my main concern when it comes to recommending supplements for my patients. The line of products offered by vitalityPRO is not only in line with the latest research in anti-ageing, but is also third-party tested and purity checked, which is of utmost importance for receiving maximal benefits from treatment."

  • Simon Jones

    Simon Jones, MBChB, MRCP, MSc

    Lead Academy Doctor at a Premier League Football Club

    "Vitality Pro is a fantastic company, clearly striving to achieve the highest standard and reliability of supplements on the market. Their range really is at the cutting edge of longevity supplements, and the independent third-party testing is incredibly reassuring in terms of quality."

  • Casey Vincent

    Casey Vincent, Two-Time Olympian

    Australian Olympics Sprinter 2000-2004

    “I have done my research on vitalityPRO products and without a doubt have found their supplements to be far superior to the competition”

  • Tony Pemberton

    Tony Pemberton, FdENG

    Certified Epigenetic Coach

    "I'm very discerning of either overpriced supplements or poor quality ingredients, but I have to say Vitality PRO products are superb while still being great value. I use them myself for improving ageing biomarkers, and I am happy to recommend them to both my clients and viewership."

  • Kim Forteza

    Kim Forteza, MSc, PGCert, TPU, CNS

    Elite Athlete Coach

    "I have found Vitality Pro to have a great commitment to the client. They generate trust due to their service, presentation, formulation, technical explanations, and third-party analysis of each of their products. It is a brand that I always recommend when looking for excellence in a product, both for my athletes and for all people looking for supplementation with guarantees."

  • Emel Gunay

    Emel Gunay, DipCNM, mBANT, mIFM

    Nutritional Therapist and Research Manager at OMNOS

    "V​itality-PRO offers excellent customer support, knowledgeable staff, and great value for money on high-quality supplements. ​​The products are of outstanding quality, and I appreciate their dedication to quality and transparency, which ensures safety and compliance for my clients. I​ can highly recommend ​them."

  • Jonny Hirtenstein

    Jonny Hirtenstein, MChiro, DC, ACN

    Founder and Lead Chiropractor at Foundation For Life

    ”As a clinician I appreciate Vitality Pro's passion for producing products that are designed to deliver great results and knowing that they independently test all the batches of the products is very reassuring. Ultimately I know that they care about everything they do, and are striving to produce some of the most cutting edge products on the market.”

  • Dr. Zain Khan

    Dr. Zain Khan, MBBS

    British Medical Association Executive Council Member

    “A professional supplement company who aim to be transparent, innovative and trustworthy. They invest time and money into conducting independent lab tests to verify the purity and quality of their products, ensuring that you receive precisely what you pay for.”

  • Dr James Hetfield

    Dr James Hetfield, Lead Doctor

    Lead Doctor

    Specialise in being a doctor

  • Andy Smith

    Andy Smith, PEMF Expert

    CEO of NewMed & Founder of CELLER8

    "Vitality Pro offers an impressive range of high-quality supplements, and their Magnesium Glycinate is my personal favourite. I love stacking it with my daily PEMF sessions as they complement each other perfectly for enhanced wellness. I trust Vitality Pro for reliable vitamins and supplements, and I’m always happy to recommend them to my customers!"

    •

    Frequently Bought Together

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    £32.00

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  • NMN NMN

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    £49.00

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    £25.00

    As an alternative to Resveratrol, some studies suggest that Pterostilbene may be up to five times more bioavailable and better tolerated.
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    A natural anti-allergy supplement, Quercetin is also an effective senolytic, reducing inflammatory molecules.
    Cellular Health Inflammation Immunity

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    Customs Fees: There may be customs to pay depending on your country’s local requirements. We will do what we can to avoid or minimise these as much as possible. If import charges are required, you will receive an email or text with customs clearance and payment instructions.

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    We want you to feel confident trying our products. If you're not satisfied for any reason, you can return your product within 60 days of receiving it for a full refund.

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    • We'll send you the address to return your product to. Please include a note with your order number inside the parcel so we can identify your return.
    • Once your return is received, we'll process your refund within 7 days.

    Return shipping costs: You'll need to arrange and pay for return shipping unless the product arrived faulty or damaged. All returns are sent to our UK return address. If you're ordering from outside the UK, please keep in mind that international return shipping can be expensive.

    Multiple bottles or larger quantities: If you buy multiple bottles or a larger quantity of the same product in a single order, the guarantee covers the use of one bottle, or the smallest individual size supplied. Any additional unopened units must be returned to receive a refund.

    For example, if you order 180 capsules and receive 2 × 90-capsule bottles, you can open and use one 90-capsule bottle. The second bottle must be returned.

    The 60-Day Satisfaction Guarantee does not apply to our 100g NMN or 100g Resveratrol products, as we offer smaller 20g and 30g options to give you the opportunity to try the product before committing to a larger supply.

    Get Support

    Call us

    +44 (0) 1202 082 280

    Monday to Friday
    10:00am to 4:00pm (UK time)

    Email us

    support@vitality-pro.com

    We aim to respond within 48 business hours

    Send us a message

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    • Earn as you shop - collect points on eligible purchases.

    • Enjoy future savings - redeem your points for money off.

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    You can join at checkout while placing your order. Simply create an account, or sign in if you already have one.

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