Vitality Pro

Luteolin

Luteolin is a natural plant flavonoid that research indicates may reduce the build-up of senescent cells and have neuroprotective properties.

Features

  • 100mg per capsule
  • Take 1-3 per day
  • Naturally derived from Sophora Japonica
  • Suitable for vegans
  • Free from common allergens

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Third-Party Tested

Date • Batch # • Results

Purity results include Heavy Metals

Current Batch:

February 2026

•

2501431, 2501466

Previous results:

April 2024

•

BN-MSCS231201


May 2023

•

MSCS221201

GMP Certified Facility

Our supplements are manufactured in the UK, at facilities in Oxford and the North of England, following Good Manufacturing Practice (GMP) standards.

GMP sets requirements for hygiene, production, quality control, and traceability, helping ensure supplements are consistently manufactured under controlled conditions.

Our manufacturing partners hold independently issued GMP certificates. Rather than simply asking you to take our word for it, we've made these available below for you to review.

Our UK Manufacturers' GMP Certificates

Issued by Eurofins and SGS.

Manufacturer 1

Manufacturer 2

Manufacturer names have been redacted for commercial confidentiality.

ISO Quality Managed

Vitality Pro is independently certified to ISO 9001:2015, an internationally recognised standard for quality management systems.

Maintaining this certification requires ongoing monitoring, documented checks, regular reporting and independent audits. These processes help identify areas for improvement, ensure issues are addressed, and continually strengthen the systems and controls behind our supplements. It's a commitment to quality that must be demonstrated and maintained, not simply claimed.

We believe quality should be independently verified, not simply claimed. You can view our ISO 9001:2015 certificate below.

Our ISO 9001:2015 Certificate

View Our Certificate

Ingredients

View supplement label

Capsules Per Container: 90

Amount Per Capsule Amount %NRV
Luteolin 100mg *
from Sophora Japonica, natural source

Nutrient Reference Value not established*

Suitable for vegans. Contains no GMOs, common allergens, artificial colours, preservatives or flavours.

Storage & Stability

To maintain the potency and quality of your Luteolin supplement, store it in a cool (20°C-25°C) dry place, and away from light.

Quality Standards

Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015. Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Micro Quality Labs. You can view all testing certificates at www.vitality-pro.com/batch-testing.

Safety & Warnings

Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.

Interactions: Luteolin is known to inhibit members of the Cytochrome P450 class of enzymes. As a result, it may interfere with antiplatelet and blood-thinning medications such as Warfarin. It has also been shown to interact with certain chemotherapy agents and may reduce the effectiveness of certain antibiotics. Luteolin may also interact with certain stimulants including caffeine. If you are taking these medications or any other medication, please first speak with your doctor before adding luteolin to your supplement regime.

For further information regarding any other potential drug and supplement interactions with Luteolin, please see the ingredient profile on Drug Bank using the link below.* Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.

Pregnancy: If pregnant, consult your health professional before using this product.

*Drug Bank is an independent website that lists potential interactions between the ingredients in Luteolin and other medications and supplements. It may not, however, list all known possible interactions. If you are taking any medications or supplements that may interact negatively with Luteolin, please speak with your doctor before using this product.
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Key Studies to Consider

While individual results may vary due to personal health conditions, genetics, and lifestyle choices, we guarantee that the supplements you receive are made with ingredients of the highest purity, similar to those used in scientific studies, to ensure maximum results.

Senolytic

 Luteolin inhibits H2O2-induced cellular senescence via modulation of SIRT1 and p53 – Cell Study

Dosage: Luteolin treatment on HEI-OC1 cells exposed to hydrogen peroxide (H2O2)

Outcome: Reduction in cellular senescence indicators, such as senescence-associated β-galactosidase expression and DNA damage

Summary: Luteolin was shown to protect cells from ageing caused by oxidative stress. This protection is achieved by enhancing the activity of SIRT1, a protein that helps regulate cellular health, and by reducing the activity of p53, a protein related to ageing and cell damage.

Read more

Inflammation

 Luteolin Suppresses Inflammation-Associated Gene Expression by Blocking NF-κB and AP-1 Activation Pathway in Mouse Alveolar Macrophages – Cell Study

Dosage: Luteolin treatment on mouse lungs

Outcome: Reduction in inflammation markers

Summary: Luteolin was shown to significantly reduce inflammation in mouse lung cells by inhibiting certain pathways (NF-κB and AP-1) responsible for inflammatory gene activation. This suggests luteolin could be a potential treatment for lung inflammation.

Read more

 Protective Effects of Luteolin on Injury-Induced Inflammation Through Reduction of Tissue Uric Acid and Pro-Inflammatory Cytokines in Rats – Preclinical Animal Study

Dosage: Luteolin administered at 30 and 50 mg/kg doses

Outcome: Reduced inflammation and liver damage in rats

Summary: Luteolin was shown to significantly reduce inflammation and liver damage in rats by decreasing swelling, harmful enzyme levels, and inflammatory signals. It worked better at higher doses and was compared to colchicine, a known anti-inflammatory drug.

Read more

Brain Health

 Co-ultramicronized palmitoylethanolamide/luteolin normalizes GABAB-ergic activity and cortical plasticity in long COVID-19 syndrome –  Randomised Controlled Trial

Dosage: 700 mg of palmitoylethanolamide plus 70 mg of luteolin, taken twice daily for eight weeks

Outcome: Improvement in brain function and flexibility (cortical plasticity) in patients with long COVID

Summary: This study found that an eight-week treatment combining palmitoylethanolamide and luteolin helped improve brain function and flexibility in patients experiencing cognitive issues and fatigue after mild COVID-19 without affecting certain other aspects of brain activity.

Read more

 Looking for a Treatment for the Early Stage of Alzheimer’s Disease: Preclinical Evidence with Co-Ultramicronized Palmitoylethanolamide and Luteolin – Preclinical Study

Dosage: 5 mg/Kg of co-ultramicronized palmitoylethanolamide and luteolin daily for 14 days in rats

Outcome: Reduction in brain inflammation and support for neuron survival in a rat model of early-stage Alzheimer’s

Summary: A new combination treatment using palmitoylethanolamide and luteolin showed promising results in reducing brain inflammation and supporting neuron health in rats, suggesting a potential early intervention for Alzheimer’s disease.

Read more

 Co-ultraPEALut: Role in Preclinical and Clinical Delirium Manifestations – Mixed (Preclinical and Clinical Study)



Dosage: Preclinical – 1 mg/kg co-ultraPEALut in mice; Clinical – 700 mg PEA + 70 mg luteolin in elderly patients

Outcome: Improvement in cognitive functions and reduction in inflammation

Summary: This study found that a treatment called co-ultraPEALut helped mice and elderly patients recover from delirium, a condition causing confusion and loss of memory, especially after surgery. In mice, it improved brain function and reduced harmful inflammation. In elderly patients with hip fractures, it prevented and lessened the severity of delirium.

Read more

Everything You Need To Know About Luteolin

Luteolin is a naturally occurring plant molecule, known as a flavonoid, found in celery, parsley, onion leaves, and chamomile.

Research suggests it may influence cellular health, particularly by targeting senescent cells. Luteolin is different from other senolytics, such as fisetin and quercetin, for its potential effects on neuroprotection and brain health.

Luteolin has senolytic properties, meaning it selectively targets and helps clear senescent cells—cells that have stopped dividing and accumulate over time, releasing inflammatory molecules that damage neighbouring cells. Luteolin may inhibit pathways that protect senescent cells from death. By disrupting these protective mechanisms, luteolin allows for the natural clearance of these cells.

Luteolin also works as an anti-inflammatory agent by inhibiting key inflammatory signalling pathways, particularly by blocking enzymes that lead to the production of inflammatory molecules. Following similar mechanisms, Luteolin may support brain health as it has been shown to cross the blood-brain barrier. It reduces neuroinflammation by blocking inflammatory signals in the brain and supporting the survival of neurons due to less inflammatory damage. Luteolin also promotes the release of brain-derived neurotrophic factor (BDNF), a protein that supports the growth and maintenance of neurons.

A healthy body efficiently clears senescent cells to prevent chronic inflammation. As we age, immune cells responsible for identifying and clearing senescent cells become less active, and the body’s natural processes for managing cellular waste and repair slow down. Additionally, senescent cells themselves release inflammatory signals that can further impair immune function, creating a cycle where more senescent cells accumulate and fewer are cleared.

Healthy cognitive function relies on balanced inflammation and strong antioxidant defences in the brain. Ageing, oxidative stress, and neuroinflammation can impair neuronal function, leading to cognitive decline.

As we age, the body’s ability to clear senescent cells declines, leading to chronic inflammation and cellular damage, both of which accelerate age-related decline. By promoting senescent cell removal, you may reduce inflammation, protect cells, and encourage regeneration, helping to counteract the cellular damage that contributes to ageing.

Consider the following statements. If you find one or more relatable, Luteolin might be the support you’ve been searching for:

  • I’ve been exploring natural senolytics and came across luteolin’s potential benefits in clearing senescent cells.
  • I am looking for natural substances that can support a healthy inflammation response.
  • My goal is to support cognitive function as I age.
  • My healthcare professional recommended exploring Luteolin for its potential benefits.
Made to GMP Standards
ISO 9001 Certified UK Company
Independent Testing for Purity

Transparent Testing

Every batch is independently tested for identity, potency, contaminants, heavy metals, and microbial markers.

View all product tests

Luteolin test results

Date • Batch # • Results

Purity results include Heavy Metals

Current Batch:

February 2026

•

2501431, 2501466

Previous results:

April 2024

•

BN-MSCS231201


May 2023

•

MSCS221201

Frequently Asked Questions

No, they are different molecules with different effects.

Aside from it’s senolytic effects Luteolin is also a CD38 inhibitor. CD38 is an enzyme that plays a role in immune and inflammation response which is a new consumer of NAD. It is believed that by inhibiting CD38 activity, Luteolin may lead to increased NAD levels.

Both Fisetin and Luteolin are thought to be natural senolytics. The differences between them lie in their ‘off-target’ effects or their ability to work elsewhere in the body.

Fisetin is thought to be the most powerful natural senolytic. Luteolin may also work to improve various aspects of brain health because of its ability to cross the blood brain barrier.

Certainty of purity.

We are committed to the following quality controls to ensure consistency, reliability, and transparency in every product. Our goal is to raise industry standards and give you clear reasons to trust what you’re taking.
  • GMP Certified Facility

    All products are made to cGMP (current Good Manufacturing Practice) standards, the global benchmark for supplement quality. GMP standards ensure strict control over how our supplements are produced, covering everything from cleanliness to documentation and quality control. Every step is monitored to guarantee consistency and safety in every batch, so you receive the same high-quality product every time.

  • Third-Party Tested

    At the foundation of what we offer is certainty of product quality through consistent third-party testing, specifically for purity.

  • ISO Quality Managed

    ISO 9001:2015 standards are an internationally recognised framework for effective quality management. This accreditation means we follow a structured system of continuous improvement, always refining our processes to enhance product consistency and customer satisfaction. ISO accreditation ensures that every aspect of our operations, from production to customer service, is optimised. This means better oversight, reduced risk of errors, and a clear focus on delivering consistent results.

  • Transparency

    We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.

  • GMP Certified Facility

    Droplets

    Our supplements are manufactured in the UK, at facilities in Oxford and the North of England, following Good Manufacturing Practice (GMP) standards.

    GMP sets requirements for hygiene, production, quality control, and traceability, helping ensure supplements are consistently manufactured under controlled conditions.

    Our manufacturing partners hold independently issued GMP certificates. Rather than simply asking you to take our word for it, we've made these available below for you to review.

    Our UK Manufacturers' GMP Certificates

    Issued by Eurofins and SGS.

    Manufacturer 1

    Manufacturer 2

    Manufacturer names have been redacted for commercial confidentiality.

    Third-Party Tested

    Date • Batch # • Results

    Purity results include Heavy Metals

    Current Batch:

    February 2026

    •

    2501431, 2501466

    Previous results:

    April 2024

    •

    BN-MSCS231201


    May 2023

    •

    MSCS221201

    ISO Quality Managed

    Vitality Pro is independently certified to ISO 9001:2015, an internationally recognised standard for quality management systems.

    Maintaining this certification requires ongoing monitoring, documented checks, regular reporting and independent audits. These processes help identify areas for improvement, ensure issues are addressed, and continually strengthen the systems and controls behind our supplements. It's a commitment to quality that must be demonstrated and maintained, not simply claimed.

    We believe quality should be independently verified, not simply claimed. You can view our ISO 9001:2015 certificate below.

    Our ISO 9001:2015 Certificate

    View Our Certificate

    Transparency

    We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.

    Transparency means we share all the details that matter—how our products are made, tested, and verified. From publishing third-party test results to offering clear ingredient labels, we provide you with the information you need to make informed choices about your supplements. Nothing is hidden, and every product comes with full accountability.

    In a world where many supplement companies keep you in the dark, we believe you deserve complete honesty. Being transparent allows you to trust that you’re getting exactly what you expect—pure, tested supplements without hidden risks. It’s about empowering you to make confident decisions and focus on your health journey without second-guessing the products you take.

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  • Dr. Ahmet Ozyigit

    Dr. Ahmet Ozyigit, MD, MSc, PgDip

    Head of Clinical Research at Elite Hospital

    "As a physician, purity of a product is my main concern when it comes to recommending supplements for my patients. The line of products offered by vitalityPRO is not only in line with the latest research in anti-ageing, but is also third-party tested and purity checked, which is of utmost importance for receiving maximal benefits from treatment."

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    Simon Jones, MBChB, MRCP, MSc

    Lead Academy Doctor at a Premier League Football Club

    "Vitality Pro is a fantastic company, clearly striving to achieve the highest standard and reliability of supplements on the market. Their range really is at the cutting edge of longevity supplements, and the independent third-party testing is incredibly reassuring in terms of quality."

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    Casey Vincent, Two-Time Olympian

    Australian Olympics Sprinter 2000-2004

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    Certified Epigenetic Coach

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    "I have found Vitality Pro to have a great commitment to the client. They generate trust due to their service, presentation, formulation, technical explanations, and third-party analysis of each of their products. It is a brand that I always recommend when looking for excellence in a product, both for my athletes and for all people looking for supplementation with guarantees."

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    Emel Gunay, DipCNM, mBANT, mIFM

    Nutritional Therapist and Research Manager at OMNOS

    "V​itality-PRO offers excellent customer support, knowledgeable staff, and great value for money on high-quality supplements. ​​The products are of outstanding quality, and I appreciate their dedication to quality and transparency, which ensures safety and compliance for my clients. I​ can highly recommend ​them."

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    British Medical Association Executive Council Member

    “A professional supplement company who aim to be transparent, innovative and trustworthy. They invest time and money into conducting independent lab tests to verify the purity and quality of their products, ensuring that you receive precisely what you pay for.”

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    ”As a clinician I appreciate Vitality Pro's passion for producing products that are designed to deliver great results and knowing that they independently test all the batches of the products is very reassuring. Ultimately I know that they care about everything they do, and are striving to produce some of the most cutting edge products on the market.”

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    "Vitality Pro offers an impressive range of high-quality supplements, and their Magnesium Glycinate is my personal favourite. I love stacking it with my daily PEMF sessions as they complement each other perfectly for enhanced wellness. I trust Vitality Pro for reliable vitamins and supplements, and I’m always happy to recommend them to my customers!"

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