Vitality Pro
Vitality Pro
Inflammation Longevity Cellular Health

Fisetin

Senolytic
  • Fisetin
  • Fisetin
  • Fisetin
  • Fisetin
  • Fisetin
    • Fisetin
    Fisetin
    Fisetin
    Fisetin
    Fisetin

    Third-Party Tested

    GMP Certified Facility

    ISO Quality Managed

    • Why Others Choose Vitality Pro?

    Fisetin

    Senolytic

    Fisetin is a natural plant flavonoid and a senolytic, known for its ability to target and remove senescent cells, which cause chronic inflammation.

    Features

    • 100mg per capsule
    • Take 1-2 per day
    • Naturally derived from Cotinus Coggygria
    • Suitable for vegans 
    • Free from common allergens

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    Third-Party Tested

    Date • Batch # • Results

    Purity results include Heavy Metals

    Current Batch:

    January 2026

    •

    2501130

    100% Purity and Microbiology

    Previous results:

    May 2025

    •

    2401067

    98.4% Purity and Microbiology

    February 2024

    •

    BN-FT230801

    95% Purity

    September 2023

    •

    FIS09062023

    95.2% Purity

    March 2022

    •

    FIS03172022

    98.3% Purity

    March 2021

    •

    FIS03042021

    98% Purity

    GMP Certified Facility

    Our supplements are manufactured in the UK, at facilities in Oxford and the North of England, following Good Manufacturing Practice (GMP) standards.

    GMP sets requirements for hygiene, production, quality control, and traceability, helping ensure supplements are consistently manufactured under controlled conditions.

    Our manufacturing partners hold independently issued GMP certificates. Rather than simply asking you to take our word for it, we've made these available below for you to review.

    Our UK Manufacturers' GMP Certificates

    Issued by Eurofins and SGS.

    Manufacturer 1

    Manufacturer 2

    Manufacturer names have been redacted for commercial confidentiality.

    ISO Quality Managed

    Vitality Pro is independently certified to ISO 9001:2015, an internationally recognised standard for quality management systems.

    Maintaining this certification requires ongoing monitoring, documented checks, regular reporting and independent audits. These processes help identify areas for improvement, ensure issues are addressed, and continually strengthen the systems and controls behind our supplements. It's a commitment to quality that must be demonstrated and maintained, not simply claimed.

    We believe quality should be independently verified, not simply claimed. You can view our ISO 9001:2015 certificate below.

    Our ISO 9001:2015 Certificate

    View Our Certificate

    Recommended Use

    Take 1–2 capsules per day with a meal containing healthy fats. Alternatively, you may want to explore the Mayo Protocol, which involves taking high doses of fisetin for two consecutive days each month.

    Fisetin is fat-soluble, meaning it is better absorbed by the body when taken with a fat source. This can be a meal or a healthy snack, such as avocado, yoghurt, coconut, or extra virgin olive oil.

    As fisetin is an antioxidant, we recommend to avoid taking it around periods of resistance exercise or weight training, as it may reduce some of the workout's positive effects.

    Ingredients

    View supplement label

    Capsules Per Container: 60

    Amount Per Capsule Amount %NRV
    Fisetin 100mg *
    from Cotinus Coggygria, natural source

    Nutrient Reference Value not established*

    Other ingredients (all natural):

    Microcrystalline Cellulose, Rice Concentrate, Vegetable Cellulose Capsule Shell (HPMC)

    Suitable for vegans. Contains no GMOs, common allergens, artificial colours, preservatives or flavours.

    Storage & Stability

    To maintain the potency and quality of your Fisetin supplements, store them in a cool (20°C-25°C), dry place, and away from light.

    Quality Standards

    Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015. Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Micro Quality Labs. You can view all testing certificates at www.vitality-pro.com/batch-testing.

    Safety & Warnings

    Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.

    Interactions: Fisetin is known to inhibit members of the Cytochrome P450 class of enzymes. As a result, it may interfere with anti-platelet and blood-thinning medications such as Warfarin. It has also been shown to interact with certain chemotherapy agents. If you are taking these medications or any other medication, please first speak with your doctor before adding Fisetin to your supplement regime.

    For further information regarding any other potential drug and supplement interactions with, Fisetin please see the ingredient profile on Drug Bank using the link below.* Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.

    Pregnancy: If pregnant, consult your health professional before using this product.

    *Drug Bank is an independent website that lists potential interactions between the ingredients in Fisetin and other medications and supplements. It may not, however, list all known possible interactions. If you are taking any medications or supplements that may interact negatively with Fisetin, please speak with your doctor before using this product.
    1

    Key studies to consider

    While individual results may vary due to personal health conditions, genetics, and lifestyle choices, we guarantee that the supplements you receive are made with ingredients of the highest purity, similar to those used in scientific studies, to ensure maximum results.

    Senolytic

     Fisetin is a senotherapeutic that extends health and lifespan – Preclinical Animal Study

    Dosage: Mice were treated with 100mg/kg of Fisetin.

    Outcome: Fisetin reduced ageing markers in tissues, decreased age-related diseases, and increased lifespan in mice.

    Summary: Fisetin, a natural compound was shown to significantly decrease signs of ageing in mice and in human fat tissue samples. Mice treated with fisetin lived longer and had fewer age-related health issues. This suggests fisetin could potentially be used to improve health and longevity in humans.

    Read more

     Mitochondrial Aging and Senolytic Natural Products with Protective Potential  – Review

    Outcome: The review discusses the potential of natural products, including fisetin, as senolytic agents that help remove senescent cells, reducing age-related damage and supporting healthy ageing.

    Summary: Fisetin emerged as a particularly effective senolytic agent, outperforming others like quercetin, by efficiently eliminating senescent cells and supporting longevity without the need for combination therapies.

    Read more

    Longevity

     Exploring the anti-aging effects of fisetin in telomerase-deficient progeria mouse model – Preclinical Animal Study

    Dosage: Fisetin treatment through diet supplementation (500 mg/kg) and gastric gavage (20 mg/kg three times a week) for 7 weeks

    Outcome: Reduction in ageing markers and improvement in premature ageing symptoms in mice

    Summary: The study found that fisetin can effectively reverse signs of ageing in mice with a specific genetic condition that accelerates ageing. By treating these mice with fisetin, researchers observed a decrease in markers associated with ageing and a reduction in age-related damage to tissues, suggesting fisetin may have the potential as a treatment to extend healthy lifespan.

    Read more

    Inflammation

     The hydroxyflavone, fisetin, suppresses mast cell activation induced by interaction with activated T cell membranes -Cell Study

    Dosage: Fisetin applied to human cells in doses of 1, 10, 25 and 50 μm.

    Outcome: Reduction in inflammation-related activities in mast cells

    Summary: Fisetin was shown to reduce the activation of a type of immune cell involved in allergic reactions and inflammation. This suggests that fisetin might help prevent inflammation-related diseases.

    Read more

     Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signalling in LPS-induced RAW264.7 cells –  Cell Study

    Dosage:  5, 10, 20, 40, 80, and 160 μM concentrations for different amounts of time.

    Outcome: Fisetin reduced inflammation and promoted autophagy by inhibiting the PI3K/AKT/mTOR signalling pathway.

    Summary: Fisetin was found to decrease inflammatory markers and enhance autophagy in immune cells by targeting specific signalling pathways, showing its potential as an anti-inflammatory molecule.

    Read more

    Brain Health

     Fisetin ameliorates cognitive impairment by activating mitophagy and suppressing neuroinflammation in rats with sepsis-associated encephalopathy – Experimental Study

    Dosage: 1 – 50 μmol concentration solution containing fisetin

    Outcome: Improvement in cognitive function in rats

    Summary: Fisetin was found to improve brain function in rats with brain inflammation due to sepsis (a type of infection) by enhancing the cleanup of damaged cells in the brain and reducing inflammation. This suggests fisetin could be a beneficial treatment for brain issues caused by sepsis.

    Read more

     The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress – Review

    Outcome: The study reviews how fisetin reduces oxidative stress and protects brain cells thereby potentially preventing neurodegenerative diseases.

    Summary: Fisetin is shown to diminish oxidative stress and inflammation in the brain, offering protection against conditions like Alzheimer’s, Parkinson’s, and Huntington’s disease. It works by regulating key molecular pathways that reduce oxidative damage and cell death in cells in the brain called neurons.

    Read more

    Everything You Need To Know About Fisetin

    Fisetin is a naturally occurring plant flavonoid that is found in strawberries, apples, persimmons and cucumbers.

    A study published in EBioMedicine demonstrated that Fisetin was the most effective compound among those tested, significantly reducing senescent cell burden in multiple tissues.

    Fisetin primarily acts as a senolytic by selectively clearing senescent cells, which are cells that have stopped dividing but do not die. These cells release harmful molecules that promote inflammation and tissue damage. Over time, their accumulation leads to increased age-related inflammation, known as inflammaging.

    Fisetin promotes apoptosis (programmed cell death) in senescent cells by inhibiting their overactive survivial pathways making them more susceptible to cell death signals.

    While healthy cells also have survival pathways, they rely on them in a balanced way. Senescent cells depend heavily on these overactive pathways to avoid apoptosis. By targeting these exaggerated survival pathways, Fisetin selectively eliminates senescent cells, reducing their build-up and the associated inflammation, while sparing healthy cells.

    Fisetin helps control inflammation by blocking specific cellular signals that would otherwise lead to the production of inflammatory molecules. By preventing this chain reaction, fisetin may reduce the activity of inflammatory molecules, which are responsible for triggering inflammation. Additionally, fisetin boosts antioxidant levels, particularly glutathione, to neutralize reactive oxygen species (ROS) and other free radicals, lowering oxidative stress and inflammation.

    In a healthy body, senescent cells are cleared efficiently to prevent them from releasing pro-inflammatory signals.  Over time cells that are less efficient in DNA repair and protein folding also accumulate damage more readily, which encourages them to become senescent. Also, the immune system weakens (a process called immunosenescence), reducing its capacity to detect and eliminate senescent cells. As senescent cells accumulate, so does chronic inflammation, increasing demand on the body’s resources to combat it, as well as causing cellular damage.

    One of the most effective approaches to counteracting aging is clearing senescent cells. Senescent cells release inflammatory molecules and contribute to persistent low-grade inflammation, known as ‘inflammaging.’ Fisetin’s ability to target and remove these cells may reduce inflammation and oxidative damage, improving overall cellular health and increasing resilience to age-related decline.

    Consider the following statements. If you find one or more relatable, Fisetin might be the wellness support you’ve been searching for:

    • I am interested in incorporating senolytics into my longevity protocol to combat ageing at the cellular level.
    • I need to manage my inflammation without affecting my histamine levels too much, as I’ve experienced with quercetin.
    • I wish to support my cognitive function as I age and want to explore the potential benefits that fisetin may have on brain health.
    • I am looking for a senolytic that is more targeted in its approach and has fewer effects elsewhere in the body.
    • A health professional recommended Fisetin.
    Made to GMP Standards
    ISO 9001 Certified UK Company
    Independent Testing for Purity

    Transparent Testing

    Every batch is independently tested for identity, potency, contaminants, heavy metals, and microbial markers.

    View all product tests

    Fisetin test results

    Date • Batch # • Results

    Purity results include Heavy Metals

    Current Batch:

    January 2026

    •

    2501130

    100% Purity and Microbiology

    Previous results:

    May 2025

    •

    2401067

    98.4% Purity and Microbiology

    February 2024

    •

    BN-FT230801

    95% Purity

    September 2023

    •

    FIS09062023

    95.2% Purity

    March 2022

    •

    FIS03172022

    98.3% Purity

    March 2021

    •

    FIS03042021

    98% Purity

    Frequently Asked Questions

    In a healthy state, most cells replicate a certain number of times and then die to allow for the replacement of old or damaged cells. Senescent cells have stopped dividing but do not die and remain in the body. As we age, these cells can accumulate and release pro-inflammatory substances, leading to inflammation in surrounding cells. Research has shown a direct correlation between the presence of senescent cells and the ageing process.

    Yes, in lower dosages of 100 to 200 mgs, Fisetin is safe to take on a daily basis.

    Some individuals choose to run Fisetin in high doses for short periods of time and are using dosing protocols based on studies currently being conducted by the Mayo Clinic.

    The Mayo Protocol dosages are:

    • 20 mg/kg of body weight per day
    • Taken for 2 consecutive days
    • Repeated monthly for 3 months

    This would be approximately 1,400 mg daily for a 70 kg (154 lb) person.

    Both Fisetin and Quercetin are believed to be powerful natural senolytics. Their differences lie in their ‘off-target’ effects or their ability to work elsewhere in the body.

    Fisetin is thought to be the most powerful natural senolytic. It may also work to improve various aspects of brain health because of its ability to cross the blood-brain barrier. Quercetin, in addition to being a senolytic, has been shown to regulate blood sugar and help control the release of the chemical in the body responsible for allergic reactions thereby showing promise in helping to control the effects of seasonal allergies.

    Certainty of purity.

    We are committed to the following quality controls to ensure consistency, reliability, and transparency in every product. Our goal is to raise industry standards and give you clear reasons to trust what you’re taking.

  • GMP Certified Facility

    All products are made to cGMP (current Good Manufacturing Practice) standards, the global benchmark for supplement quality. GMP standards ensure strict control over how our supplements are produced, covering everything from cleanliness to documentation and quality control. Every step is monitored to guarantee consistency and safety in every batch, so you receive the same high-quality product every time.

  • Third-Party Tested

    At the foundation of what we offer is certainty of product quality through consistent third-party testing, specifically for purity.

  • ISO Quality Managed

    ISO 9001:2015 standards are an internationally recognised framework for effective quality management. This accreditation means we follow a structured system of continuous improvement, always refining our processes to enhance product consistency and customer satisfaction. ISO accreditation ensures that every aspect of our operations, from production to customer service, is optimised. This means better oversight, reduced risk of errors, and a clear focus on delivering consistent results.

  • Transparency

    We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.

    •

    GMP Certified Facility

    Droplets

    Our supplements are manufactured in the UK, at facilities in Oxford and the North of England, following Good Manufacturing Practice (GMP) standards.

    GMP sets requirements for hygiene, production, quality control, and traceability, helping ensure supplements are consistently manufactured under controlled conditions.

    Our manufacturing partners hold independently issued GMP certificates. Rather than simply asking you to take our word for it, we've made these available below for you to review.

    Our UK Manufacturers' GMP Certificates

    Issued by Eurofins and SGS.

    Manufacturer 1

    Manufacturer 2

    Manufacturer names have been redacted for commercial confidentiality.

    Third-Party Tested

    Date • Batch # • Results

    Purity results include Heavy Metals

    Current Batch:

    January 2026

    •

    2501130

    100% Purity and Microbiology

    Previous results:

    May 2025

    •

    2401067

    98.4% Purity and Microbiology

    February 2024

    •

    BN-FT230801

    95% Purity

    September 2023

    •

    FIS09062023

    95.2% Purity

    March 2022

    •

    FIS03172022

    98.3% Purity

    March 2021

    •

    FIS03042021

    98% Purity

    ISO Quality Managed

    Vitality Pro is independently certified to ISO 9001:2015, an internationally recognised standard for quality management systems.

    Maintaining this certification requires ongoing monitoring, documented checks, regular reporting and independent audits. These processes help identify areas for improvement, ensure issues are addressed, and continually strengthen the systems and controls behind our supplements. It's a commitment to quality that must be demonstrated and maintained, not simply claimed.

    We believe quality should be independently verified, not simply claimed. You can view our ISO 9001:2015 certificate below.

    Our ISO 9001:2015 Certificate

    View Our Certificate

    Transparency

    We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.

    Transparency means we share all the details that matter—how our products are made, tested, and verified. From publishing third-party test results to offering clear ingredient labels, we provide you with the information you need to make informed choices about your supplements. Nothing is hidden, and every product comes with full accountability.

    In a world where many supplement companies keep you in the dark, we believe you deserve complete honesty. Being transparent allows you to trust that you’re getting exactly what you expect—pure, tested supplements without hidden risks. It’s about empowering you to make confident decisions and focus on your health journey without second-guessing the products you take.

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    •

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