Vitality Pro
Vitality Pro
Brain Health Longevity Cellular Health

Spermidine

Autophagy
  • Spermidine
  • Spermidine
  • Spermidine
  • Spermidine
  • Spermidine
    • Spermidine
    Spermidine
    Spermidine
    Spermidine
    Spermidine

    Third-Party Tested

    GMP Certified Facility

    ISO Quality Managed

    • Why Others Choose vitalityPRO?

    Spermidine

    Autophagy

    Spermidine is a naturally occurring molecule found in the body and in plants. It is known to stimulate autophagy, the body’s natural cellular renewal and recycling process, by mimicking the low-energy state induced by fasting or high-intensity exercise and activating AMPK.

    Features

    • 4mg per capsule
    • Take 1-2 per day
    • Naturally derived from Wheat Germ Extract
    • Contains gluten but no other common allergens
    • Suitable for vegans

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    Third-Party Tested

    Date • Batch # • Results

    Purity results include Heavy Metals

    Current Batch:

    August 2025

    •

    2500411

    0.945% Concentration*

    Previous results:

    May 2024

    •

    BN10052024

    0.947% Concentration*

    September 2022

    •

    SPER24082022

    1.031% Concentration*

    GMP Certified Facility

    Our supplements are manufactured in the UK, at facilities in Oxford and the North of England, following Good Manufacturing Practice (GMP) standards.

    GMP sets requirements for hygiene, production, quality control, and traceability, helping ensure supplements are consistently manufactured under controlled conditions.

    Our manufacturing partners hold independently issued GMP certificates. Rather than simply asking you to take our word for it, we've made these available below for you to review.

    Our UK Manufacturers' GMP Certificates

    Issued by Eurofins and SGS.

    Manufacturer 1

    Manufacturer 2

    Manufacturer names have been redacted for commercial confidentiality.

    ISO Quality Managed

    Vitality Pro is independently certified to ISO 9001:2015, an internationally recognised standard for quality management systems.

    Maintaining this certification requires ongoing monitoring, documented checks, regular reporting and independent audits. These processes help identify areas for improvement, ensure issues are addressed, and continually strengthen the systems and controls behind our supplements. It's a commitment to quality that must be demonstrated and maintained, not simply claimed.

    We believe quality should be independently verified, not simply claimed. You can view our ISO 9001:2015 certificate below.

    Our ISO 9001:2015 Certificate

    View Our Certificate

    Recommended Use

    Take 1-2 capsules per day. This is equal to either 4mg or 8mg of Spermidine.

    We recommend taking Advanced Spermidine after your last meal of the day to help the body transition into a state of autophagy between meals. This timing will also enhance the benefits of fasting.

    Ingredients

    View supplement label

    Capsules Per Container: 60

    Amount Per Capsule Amount %NRV
    Spermidine >4mg *
    from Wheat Germ Extract, a natural source

    Nutrient Reference Value not established*

    Other ingredients (all natural): Rice Bran, Vegetable Cellulose Capsule Shell (HPMC).

    Contains no GMOs, artificial colours, preservatives or flavours. Contains GLUTEN.

    Suitable for vegans. See allergens in bold.

    Storage & Stability

    To maintain the potency and quality of your Spermidine supplements, store them in a cool (20°C-25°C), dry place and away from light.

    Quality Standards

    Manufacturing: Our supplements are manufactured in the UK to Good Manufacturing Practice (GMP) standards. We also maintain an ISO 9001:2015-certified quality management system.

    Independent batch testing: Every batch undergoes independent laboratory testing to verify quality, including purity. Testing is carried out by ISO 17025-accredited laboratories, including Certified Labs (formerly Micro Quality Labs).

    We don't just make claims about quality. We publish the evidence. You can review our Certificates of Analysis on our product testing page.

    Safety & Warnings

    Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.

    Interactions: As of 10 November 2024, there are no known published direct interactions between Spermidine and other medications. However, this does not mean interactions do not exist. Spermidine is a supplement that may improve insulin sensitivity; if you take medications and/or other supplements to help manage your blood sugar, you should first speak with your doctor before adding Spermidine to your supplement regime.

    For further information regarding any other potential drug and supplement interactions of Spermidine please see the individual ingredient profile on Drug Bank*. Allergy: Contains wheat (gluten) from wheat germ extract. Not suitable for individuals with coeliac disease, wheat allergies or gluten intolerance. Do not use if you are hypersensitive to any of the ingredients. Consult a healthcare professional before use if you are taking medication.

    Pregnancy: If pregnant, consult your health professional before using this product.

    *Drug Bank is an independent website that lists potential interactions between the ingredients in Spermidine and other medications and supplements. It may not, however, list all known possible interactions. If you are taking any medications or supplements you feel may interact negatively with Spermidine please first speak with your doctor before using this product.
    1

    Key Studies to Consider

    While individual results may vary due to personal health conditions, genetics, and lifestyle choices, we guarantee that the supplements you receive are made with ingredients of the highest purity, similar to those used in scientific studies, to ensure maximum results.

    Autophagy

    Molecular basis of the ‘anti-aging’ effect of spermidine and other natural polyamines – Review

    Outcome: Autophagy is the main way by which spermidine exerts health effects.

    Summary: Spermidine, a natural polyamine, boosts autophagy and may also reduce inflammation, improve fat metabolism, and regulate cell growth and death by controlling the activity of the AMPK pathway to support healthy ageing.

    Read more

     Spermidine is essential for fasting-mediated autophagy and longevity – Review

    Outcome: Fasting increased spermidine levels across species, promoting autophagy and extending lifespan through spermidine-dependent mechanisms.

    Summary: This study highlights the key role of spermidine in activating autophagy during fasting. By increasing spermidine levels, fasting enhances the body’s ability to clear damaged cells, improving longevity and reducing the risk of age-related diseases. Blocking spermidine production was shown to disrupt these benefits, revealing spermidine’s essential role in fasting-mediated health improvements.

    Read more

    Longevity

    Spermidine and spermine are enriched in whole blood of nona/centenarians – Cross-sectional observational study

    Outcome: Levels of polyamines (spermidine and spermine) were found in the blood of older individuals.

    Summary: This study found that very old people (aged 90-106) have higher levels of certain healthy spermidine in their blood compared to younger groups. This suggests that polyamines may play a role in promoting a longer life.

    Read more

    Induction of Autophagy by Spermidine Promotes Longevity – Review

    Outcome: Increased lifespan and reduced oxidative stress in various organisms

    Summary: Spermidine supplementation was shown to significantly increase the lifespan of yeast, flies, worms, and even human immune cells by reducing damage from oxidative stress (a type of cell damage associated with ageing) and triggering a beneficial process called autophagy, which helps get rid of damaged cells.

    Read more

     Spermidine dietary supplementation and polyamines level in reference to survival and lifespan of honey bees – Randomised Controlled Trial

    Dosage: 0.1 mM and 1 mM spermidine

    Outcome: Increased survival rate, lifespan, and antioxidant capacity in honey bees.

    Summary: Spermidine supplementation improved honey bee lifespan and survival by reducing oxidative stress and increasing antioxidant capacity.

    Read more

    New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases – Review

    Outcome: Spermidine supplementation shows promise in delaying aging and extending lifespan by promoting autophagy, reducing inflammation, and supporting cell health.

    Summary: This study highlights how spermidine can slow down the aging process and reduce age-related diseases by improving cellular health, boosting autophagy, and managing inflammation.

    Read more

    Brain Health

     Spermidine intake is associated with cortical thickness and hippocampal volume in older adults – Cross-sectional Study

    Dosage: Self-reported dietary intake assessed through a food frequency questionnaire

    Outcome: Higher spermidine intake was linked to larger hippocampal volume and greater cortical thickness in brain areas affected by Alzheimer’s disease.

    Summary: This study suggests that dietary spermidine may help protect brain structure, including memory-related regions, in older adults, making it a potential dietary approach for supporting brain health.

    Read more

    The effect of spermidine on memory performance in older adults at risk for dementia – Randomised Controlled Trial

    Dosage: Spermidine-rich plant extract for 3 months, dosage not disclosed.

    Outcome: Improved memory performance in older adults with subjective cognitive decline

    Summary: Spermidine supplementation over three months moderately improved memory and discrimination ability in older adults at risk of dementia, suggesting its potential to support brain health by enhancing memory-related neural functions.

    Read more

    Everything You Need To Know About Spermidine

    Spermidine is a naturally occurring polyamine found in all living cells, as well as in certain foods like wheat germ, soybeans, and aged cheese. It plays an important role in cell growth, division, and maintenance. Spermidine is also linked to cellular processes like autophagy, which helps remove damaged cell components and promotes cellular renewal.

    Spermidine induces autophagy, a cellular process where damaged or dysfunctional components within the cell are broken down and recycled. Spermidine works by inhibiting enzymes like histone acetyltransferases, increasing cell stress resistance and triggering autophagy, primarily through activating AMPK, a key regulator of energy balance within cells. AMPK triggers autophagy as a survival response to low-energy conditions, enabling the body to generate and conserve energy in alternative ways. Through autophagy, unnecessary or damaged cell components are broken down and then recycled into new molecules for energy production. By clearing out damaged components, spermidine supports cellular health and longevity at the molecular level.

    Healthy autophagy is the body’s way of removing and recycling damaged cell components, which keeps cells functioning efficiently and reduces the accumulation of dysfunctional cells. Autophagy declines with age due to lower cellular energy, weaker hormonal signals, and accumulated damage that disrupt autophagy pathways. This reduced autophagy allows damaged components to build up in cells, depleting cellular resources and accelerating age-related decline. Maintaining optimal Spermidine levels can help sustain autophagy, ensuring that cells continue to repair and renew themselves.

    Spermidine promotes longevity by supporting autophagy, reducing cellular waste, and limiting accumulated cellular dysfunction. Studies show it aids cellular health, which is key to sustaining physical and cognitive ability as we age.

    Consider the following statements. If you find one or more relatable, Spermidine might be the wellness support you’ve been searching for:

    • I’m interested in boosting my body’s autophagy process to promote cellular renewal and longevity.
    • I’ve read about the benefits of fasting for autophagy, but I want a more consistent, accessible way to support these cellular processes.
    • I’m looking for a supplement that complements my existing health routine to support healthy hair growth and strength.
    • My goal is to maintain and enhance cognitive function as I age, and I’m interested in spermidine’s potential benefits for brain health.
    • I’ve tried various supplements for health and longevity, but I’m looking to add spermidine to my regimen for its unique cellular benefits.
    • My healthcare professional has recommended exploring supplements that support autophagy and cellular health.
    Made to GMP Standards
    ISO 9001 Certified UK Company
    Independent Testing for Purity

    Transparent Testing

    Every batch is independently tested for identity, potency, contaminants, heavy metals, and microbial markers.

    View all product tests

    Spermidine test results

    Date • Batch # • Results

    Purity results include Heavy Metals

    Current Batch:

    August 2025

    •

    2500411

    0.945% Concentration*

    Previous results:

    May 2024

    •

    BN10052024

    0.947% Concentration*

    September 2022

    •

    SPER24082022

    1.031% Concentration*

    Frequently Asked Questions

    Spermidine is naturally found in foods such as wheat, legumes, and soy. However, due to the low amounts present in food, a supplement is likely the best option to receive the full benefits of Spermidine.

    Our Spermidine is derived from wheat germ extract and contains wheat (gluten). It is not suitable for individuals with coeliac disease, wheat allergies or gluten intolerance. Do not take Spermidine if you are hypersensitive to any of the ingredients. If you are taking medication, consult a healthcare professional before use.

    Spermidine can help the body more easily enter into a fasted state by increasing levels of the fasting enzyme AMPK, which is an energy-regulating molecule that helps the body enter into a state of autophagy.

    We originally included small amounts of thiamine (vitamin B1) and zinc to support carbohydrate metabolism and immune function. However, many customers and practitioners preferred a pure spermidine formula to avoid overlapping dosages with their own supplements. The result is a more versatile product, easier to combine with personalised plans.

    Certainty of purity.

    We are committed to the following quality controls to ensure consistency, reliability, and transparency in every product. Our goal is to raise industry standards and give you clear reasons to trust what you’re taking.

  • GMP Certified Facility

    All products are made to cGMP (current Good Manufacturing Practice) standards, the global benchmark for supplement quality. GMP standards ensure strict control over how our supplements are produced, covering everything from cleanliness to documentation and quality control. Every step is monitored to guarantee consistency and safety in every batch, so you receive the same high-quality product every time.

  • Third-Party Tested

    At the foundation of what we offer is certainty of product quality through consistent third-party testing, specifically for purity.

  • ISO Quality Managed

    ISO 9001:2015 standards are an internationally recognised framework for effective quality management. This accreditation means we follow a structured system of continuous improvement, always refining our processes to enhance product consistency and customer satisfaction. ISO accreditation ensures that every aspect of our operations, from production to customer service, is optimised. This means better oversight, reduced risk of errors, and a clear focus on delivering consistent results.

  • Transparency

    We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.

    •

    GMP Certified Facility

    Droplets

    Our supplements are manufactured in the UK, at facilities in Oxford and the North of England, following Good Manufacturing Practice (GMP) standards.

    GMP sets requirements for hygiene, production, quality control, and traceability, helping ensure supplements are consistently manufactured under controlled conditions.

    Our manufacturing partners hold independently issued GMP certificates. Rather than simply asking you to take our word for it, we've made these available below for you to review.

    Our UK Manufacturers' GMP Certificates

    Issued by Eurofins and SGS.

    Manufacturer 1

    Manufacturer 2

    Manufacturer names have been redacted for commercial confidentiality.

    Third-Party Tested

    Date • Batch # • Results

    Purity results include Heavy Metals

    Current Batch:

    August 2025

    •

    2500411

    0.945% Concentration*

    Previous results:

    May 2024

    •

    BN10052024

    0.947% Concentration*

    September 2022

    •

    SPER24082022

    1.031% Concentration*

    ISO Quality Managed

    Vitality Pro is independently certified to ISO 9001:2015, an internationally recognised standard for quality management systems.

    Maintaining this certification requires ongoing monitoring, documented checks, regular reporting and independent audits. These processes help identify areas for improvement, ensure issues are addressed, and continually strengthen the systems and controls behind our supplements. It's a commitment to quality that must be demonstrated and maintained, not simply claimed.

    We believe quality should be independently verified, not simply claimed. You can view our ISO 9001:2015 certificate below.

    Our ISO 9001:2015 Certificate

    View Our Certificate

    Transparency

    We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.

    Transparency means we share all the details that matter—how our products are made, tested, and verified. From publishing third-party test results to offering clear ingredient labels, we provide you with the information you need to make informed choices about your supplements. Nothing is hidden, and every product comes with full accountability.

    In a world where many supplement companies keep you in the dark, we believe you deserve complete honesty. Being transparent allows you to trust that you’re getting exactly what you expect—pure, tested supplements without hidden risks. It’s about empowering you to make confident decisions and focus on your health journey without second-guessing the products you take.

    Trusted By Professionals & Industry Experts

  • Dr. Ahmet Ozyigit

    Dr. Ahmet Ozyigit, MD, MSc, PgDip

    Head of Clinical Research at Elite Hospital

    "As a physician, purity of a product is my main concern when it comes to recommending supplements for my patients. The line of products offered by vitalityPRO is not only in line with the latest research in anti-ageing, but is also third-party tested and purity checked, which is of utmost importance for receiving maximal benefits from treatment."

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    Simon Jones, MBChB, MRCP, MSc

    Lead Academy Doctor at a Premier League Football Club

    "Vitality Pro is a fantastic company, clearly striving to achieve the highest standard and reliability of supplements on the market. Their range really is at the cutting edge of longevity supplements, and the independent third-party testing is incredibly reassuring in terms of quality."

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    Casey Vincent, Two-Time Olympian

    Australian Olympics Sprinter 2000-2004

    “I have done my research on vitalityPRO products and without a doubt have found their supplements to be far superior to the competition”

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    Tony Pemberton, FdENG

    Certified Epigenetic Coach

    "I'm very discerning of either overpriced supplements or poor quality ingredients, but I have to say Vitality PRO products are superb while still being great value. I use them myself for improving ageing biomarkers, and I am happy to recommend them to both my clients and viewership."

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    Kim Forteza, MSc, PGCert, TPU, CNS

    Elite Athlete Coach

    "I have found Vitality Pro to have a great commitment to the client. They generate trust due to their service, presentation, formulation, technical explanations, and third-party analysis of each of their products. It is a brand that I always recommend when looking for excellence in a product, both for my athletes and for all people looking for supplementation with guarantees."

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    Emel Gunay, DipCNM, mBANT, mIFM

    Nutritional Therapist and Research Manager at OMNOS

    "V​itality-PRO offers excellent customer support, knowledgeable staff, and great value for money on high-quality supplements. ​​The products are of outstanding quality, and I appreciate their dedication to quality and transparency, which ensures safety and compliance for my clients. I​ can highly recommend ​them."

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    Jonny Hirtenstein, MChiro, DC, ACN

    Founder and Lead Chiropractor at Foundation For Life

    ”As a clinician I appreciate Vitality Pro's passion for producing products that are designed to deliver great results and knowing that they independently test all the batches of the products is very reassuring. Ultimately I know that they care about everything they do, and are striving to produce some of the most cutting edge products on the market.”

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    British Medical Association Executive Council Member

    “A professional supplement company who aim to be transparent, innovative and trustworthy. They invest time and money into conducting independent lab tests to verify the purity and quality of their products, ensuring that you receive precisely what you pay for.”

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    Specialise in being a doctor

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    CEO of NewMed & Founder of CELLER8

    "Vitality Pro offers an impressive range of high-quality supplements, and their Magnesium Glycinate is my personal favourite. I love stacking it with my daily PEMF sessions as they complement each other perfectly for enhanced wellness. I trust Vitality Pro for reliable vitamins and supplements, and I’m always happy to recommend them to my customers!"

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    Multiple bottles or larger quantities: If you buy multiple bottles or a larger quantity of the same product in a single order, the guarantee covers the use of one bottle, or the smallest individual size supplied. Any additional unopened units must be returned to receive a refund.

    For example, if you order 180 capsules and receive 2 × 90-capsule bottles, you can open and use one 90-capsule bottle. The second bottle must be returned.

    The 60-Day Satisfaction Guarantee does not apply to our 100g NMN or 100g Resveratrol products, as we offer smaller 20g and 30g options to give you the opportunity to try the product before committing to a larger supply.

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