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    (12 customer reviews)

    $44 or subscribe and save 5%

    • Natural Spermidine (4mg) + Zinc (2.5mg) + Thiamine (0.1mg) per capsule
    • 60 capsules per bottle (120 capsule option available until July)
    • Natural Spermidine derived from 400mg Concentrated Wheat Germ Extract per capsule
    • Contains no GMOs, artificial colours, preservatives, or flavours
    • Suitable for vegans
    • 100% biodegradable packaging

    Take either 1 or 2 capsules per day after a meal. This is equal to either 4mg or 8mg of Spermidine.

    We add small amounts of thiamine and zinc because studies have shown that they improve the immune response in your body and contribute to the process of metabolising food into energy – a key part of the Autophagy process.

    Tip: If you are intermittent fasting, we recommend taking Spermidine with your last meal of the day to enhance your body’s move into ketosis and autophagy.

    Additional ingredients: Vegetable Cellulose (Capsule), Rice Bran

    *All Vitality Pro products are manufactured and third-party tested to GMP standards and ISO 9001:2015 quality certified.


    SKU: SPERM60 Categories: , , Tag:

    Warning: Do not exceed recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.

    Additional information

    Choose your pack size (click here)

    60 capsules, 120 capsules


    1. I take a broad spectrum of supplements daily. I have a small bowl of tablets and capsules to get through. Ease of swallowing is therefore a VERY IMPORTANT FACTOR for me. I find these CAPSULES (see pic) EASY TO SWALLOW as they are not too large and not at all powdery. They are not ‘dry’ in the mouth. This is why I usually prefer capsules.

      In the interest of curiosity (and I’m not recommending this) I allowed one to stay in my mouth to see what would happen. It did NOT QUICKLY DISINTEGRATE. It was not unpleasant. I then chewed it up. The powder inside and the remains of the capsule formed a paste which wasn’t too slimy. The taste was reminiscent of a breakfast cereal except quite strong.

      I much prefer a plastic bottle BUT THIS IS NOT A GOOD ONE! Quick and easy to open BUT closes INSECURELY. I estimate that there is only about 90 degrees of rotation from fully open to fully closed. This wouldn’t be a problem except if you push it even slightly ‘tight’ the lid goes past the limit and goes loose again. That is to say YOU CAN’T GET IT TIGHT.

      I am taking this supplement and so far I feel great. I’m not in a position to provide scientific data from my simple experiments but I’m very practised at listening to my body and mind. I’m happy to continue with this supplement.

      I hope these opinions and observations are helpful.

    2. I was looking for a natural and pure spermidine supplement and this one certainly fits the bill. It’s third-party tested and has been verified for quality and purity, which makes me feel confident in the product I’m using.

      The capsules are easy to swallow and I noticed a difference in my energy levels after just a few days of using them. I have more energy throughout the day and I’m not as easily tired. I also have a better sense of mental clarity and focus, which is definitely helpful for getting through my day.

      The capsules are also very affordable, making them a great value. I would definitely recommend this product to anyone looking for a natural and pure spermidine supplement.

      The only negative I’ve noticed is that the capsules can be a bit large, so if you have trouble swallowing pills you may want to look for a smaller size.

    3. The capsules are standard type, with no flavour or particular odour. I do find swallowing the tablets easy but make this a quick process with some water and take the capsule down. They are not pleasant but all tablets are similar in this respect i.e. some water and down it goes. I note the healthy ageing support and that this is a food supplement which should provide beneficial results. Having read the detail this should be all good and provide good results whilst taking these.

    4. Spermidine is a polyamine, meaning it has two or more primary amino groups. It is naturally occurring and is widely encountered in ribosomes and living tissues. It plays a critical role in cell function and survival.

      Spermidine and putrescine are known to stimulate autophagy. A system that breaks down waste inside cells and recycles cellular components. Autophagy allows damaged or defective mitochondria to be broken down and disposed of.

      Although the primary way in which spermidine appears to support longevity is via autophagy, there is also evidence that it supports health and longevity in other ways. Some studies suggest that it has anti-inflammatory properties and is involved in lipid metabolism, cell growth and proliferation, and programmed cell death, known as apoptosis.

      It is essential in regulating various biological processes, including intracellular pH levels and maintaining cell membrane potential.
      Spermidine is of interest to scientists in the context of ageing because it is a critical morphogenetic determinant for the lifespan of cells and living tissues.
      The ability of spermidine to trigger autophagy is thought to be the primary mechanism by which it appears to slow down ageing and support longevity. Autophagy has also been linked to clearing out toxin proteins linked to Parkinson’s and Alzheimer’s, so spermidine is showing real promise as a brain health superstar.

      I started taking spermidine due to its incredible effects on ageing and brain health. I am in awe of its potential and am constantly researching and testing brain supplements and antioxidants. It was proven that the external supply of spermidine positively impacts brain health, memory and overall cognitive functioning. I depend on my brain and engage it a lot at work. Nutritional/supplemental spermidine is also associated with many cardioprotective and anti-inflammatory actions in brain cells, which also help preserve brain functioning.
      The spermidine supplement is the third I have purchased from Vitality Pro, and I am delighted with their approach to the environment by having biodegradable tubs. Moreover, I am impressed with the premium quality and purity of the ingredients. I trust the brand because they deliver superior supplements. I am saying this as a supplement freak who will start rattling soon 😊.
      I take my spermidine in the morning, and it is recommended to be paired high with high-fat food because it is fat-soluble. I prefer milk or olive oil. However, I must warn you that the smell is atrocious, at least for me. It is not as bad as NAC, which smells like sulphur but lingers with me. Once swallowed, it is fine, but that smell stays with me for a while.

      Nonetheless, I want to underline that I take the supplement and do not expect some miraculous change. I live by the principle that feeding your body adequately from the inside and out will support it to perform well. Therefore, I cannot write about positive effects because they probably are minuscule at the mitochondrial level. However, knowing that I provide such precious and pure ingredients impacts my perception and well-being.

      I will continue taking spermidine and purchasing products from Vitality Pro because they are premium quality and pure.

    5. I really appreciate the fact that this is a clearly marked vegan supplement with a vegetarian capsule shell. The capsules are typical size and easy enough to swallow. You are getting 120 here and if you stick to the recommended serving size of 1-2 then they will last you up to 4 months. You get a decent expiry date so more than enough time to use this supplement up. Certainly one to consider.

    6. Spermidine has a range of purported longevity-enhancing benefits including cardiovascular and cognitive function support, and is the focus of a lot of recent research into its efficacy and a big recent buzz. This capsule-based source is really easy way to work it into your everyday nutrition, not least because it’s a simple, one-a-day, easy to swallow dose.

      The amount of compound per capsule is 4mg, which is at the higher end of spermidine supplements currently on the market. That actually makes it quite good value compared to some lower dose products, an important consideration given that it’s not an inexpensive supplement right now. You get 120 capsules, or four months’ supply at the one-a-day suggested frequency (although you can take up to two capsules if required). They have a slightly malty aroma to them, but it’s not unpleasant.

      The spermidine itself is plant-sourced from wheatgerm, and the capsules are vegan-friendly too.

      All in all this seems like a quality, value source of high-dose spermidine if you’re looking to work this into your nutrition.

    7. Despite the name and where it was originally extracted from many years ago, this product is extracted from wheat germ and is 100% natural.

      At 50p/capsule, this is in line with the cost of many others I have tried.

      The main purpose behind this is the extension of healthspan and (potentially) lifespan, as studies have shown the concentration of spermidine in the body to decrease with age, and that there is an increase in healthspan and lifespan in tested animals with this being added to their diet.

      Human studies are lacking, but some studies have shown that supplementation led to improvements in dementia, and some population studies how shown that higher levels of spermidine in the human diet have been associated with reduced mortality (meaning fewer deaths) overall and particularly from cardiovascular and cancer-related mortality, and a reduction in morbidity (meaning less incidence of any/all disease).

      The mechanism of action behind Spermidine has been suggested to be a process called Autophagy, which is when the body destroys old and damaged cells as a way to make room for new and undamaged cells. The body’s ability to do this itself declines with age, but some agents, such as spermidine, allow it to happen with better efficacy.

      It is worth knowing, that like many longevity-promoting nutrients this is deemed to be a ‘calorie restriction mimetic’, as it causes the body to undergo the same processes that it would if you significantly cut your calorie intake (typically by 40%+) for a period of time, or similarly to what happens when you practice intermittent fasting.

      As I am 32, I may only see a little benefit from taking this, compared to my parents in their mid 60s who should see a much larger benefit. According to a chart that I can find, spermidine levels in their body should be well below half of mine, and mine are probably only 25% (at maximum) down from what they were when I was 20.

      Unfortunately, it is not something that you will feel working. I am not even sure if this is any commercial test that you can take to determine the levels of spermidine in your blood.

      All we can do is take this daily and assume that the science (which is promising, but very underdeveloped) is right and that this will do what we expect it can do.

      While I am currently not taking it myself, it is a very promising and (seemingly) safe compound and I fully intend to take it as soon as I can regularly afford to.

      The bottle does suggest to take one capsule per day, for a dosage of 4mg of spermidine daily. It’s difficult to say whether that is the most ideal dosage or not as the science is not complete yet.

      It appears to be an excellent quality product, and is sold in good faith to those of us who understand about the ‘potential’ effects of these nutrients.

      The cost seems reasonable, and is clearly not overpriced unlike some of the other brands out there who push longevity supplements for eye-watering amounts.

      Overall, it is a good product, with promising science, and you get good service from a reliable brand.

    8. I’ve been looking for this product everywhere and it’s quite hard to find. It’s the elixir of youthfulness, so gives skin a certain vitality and raises energy levels. I’ve noticed a real difference in my metabolism and skin after taking 120 of these capsules. They are expensive, but I have every reason to believe that they are worth it.

    9. Spermidine essentially encourages autophagy – a natural (but rare) state your body reaches when it pretty much absorbs the dead cells to make way for new, healthy cells. For example, if you lose a lot of weight and have loose skin, autophagy can cause your body to “absorb” the loose skin cells, giving you a taut shape again. It’s an incredible process, and there’s still little known about it. But it’s kind of the ultimate stage of ketosis, which is hard to get into in and of itself.

      So autophagy is really hard to get into, but Spermidine helps the process along *significantly*.

      It also:

      ~ improves sleep quality

      ~ strengthens hair and nails

      ~ increases energy levels

      ~ and a myriad other wonderful things.

      The only issue is it tastes awful – you may be reading that and thinking “How bad can it be?” It’s really bad. Taking it in capsule form eases it slightly but you’ll still taste it as it goes down if you don’t overpower the flavour right away. And it smells exactly like it sounds… I’m trying to be discreet here! All I can say, fellas, is if your lady enjoys these, marry her.

      You get 120 capsules in the bottle, and the directions say to take either 1 or 2 a day – if you’re new to Spermidine, I would really, really suggest starting with one a day and see how it goes. Plus, one a day means the bottle will last 4 months, which is excellent.

    10. I recently started taking the Natural Pure Spermidine Supplement and have noticed a significant improvement in my energy levels. The supplement is made with high quality ingredients that are safe and effective. I appreciate that the supplement is a natural way to boost my energy levels and maintain my youthful body functions. Spermidine is a powerful element that stimulates cytoprotective macroautophagy/autophagy, which is essential for maintaining a healthy body. I am happy to have found such an effective and natural supplement to support my health and well-being.

    11. This is the supplement that has been making waves recently so I was excited to try this just because of all of the associated health benefits and all the benefits of autophagy without the fasting. the recommended serving size is two a day after a meal I’m not sure if it’s working as it’s early day but there have been no adverse reactions. they are in capsule form so easy to swallow and have no aftertaste at all. they will last two months if taking the maximum dosage and longer if you take half. so far I’m liking these.

    12. A week in they seem to be going strong, you get a whopping 120 capsules in the box which are easy to swallow and leave no nasty taste. The benefits seems to be working well and I am definitely noticing a difference in the children. Slightly more expensive than others on the market but overall a great find. I would purchase again 🙂

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