Vitality Pro

Energy Support Bundle

Energy Support Bundle

Alex Manos' Mitochondrial support bundle includes Magnesium Threonate, PQQ, Spermidine and Trans Resveratrol. The bundle aims to support the production of new mitochondria and the repair and maintenance of existing ones.

Free from common allergens. Suitable for vegans.

Includes a month's supply of:

 

Features

  • Magnesium Threonate
  • PQQ
  • Spermidine
  • Trans Resveratrol

$278.00

The longer you subscribe, the more you save.

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Third-Party Tested

Please see our product testing page for the most up-to-date testing on each product.

You can find our product testing page here.

GMP Certified Facility

Our supplements are manufactured in the UK, at facilities in Oxford and the North of England, following Good Manufacturing Practice (GMP) standards.

GMP sets requirements for hygiene, production, quality control, and traceability, helping ensure supplements are consistently manufactured under controlled conditions.

Our manufacturing partners hold independently issued GMP certificates. Rather than simply asking you to take our word for it, we've made these available below for you to review.

Our UK Manufacturers' GMP Certificates

Issued by Eurofins and SGS.

Manufacturer 1

Manufacturer 2

Manufacturer names have been redacted for commercial confidentiality.

ISO Quality Managed

Vitality Pro is independently certified to ISO 9001:2015, an internationally recognised standard for quality management systems.

Maintaining this certification requires ongoing monitoring, documented checks, regular reporting and independent audits. These processes help identify areas for improvement, ensure issues are addressed, and continually strengthen the systems and controls behind our supplements. It's a commitment to quality that must be demonstrated and maintained, not simply claimed.

We believe quality should be independently verified, not simply claimed. You can view our ISO 9001:2015 certificate below.

Our ISO 9001:2015 Certificate

View Our Certificate

Ingredients

View supplement label

Magnesium Threonate

Capsules Per Container: 90

Amount Per Capsule Amount %NRV
Magtein® Magnesium Threonate 667mg *
Fully reacted
Providing 48mg Elemental Magnesium * 12.8%
Nutrient Reference Value not established*

PQQ

View supplement label

Capsules Per Container: 60

Amount Per Capsule Amount %NRV
PQQ 20mg *
Pyrroloquinoline Quinone
Nutrient Reference Value not established*
Suitable for vegans. Contains no GMOs, common allergens, artificial colours, preservatives or flavours.

Spermidine

View supplement label

Capsules Per Container: 60

Amount Per Capsule Amount %NRV
Spermidine >4mg *
from Wheat Germ Extract, a natural source
Nutrient Reference Value not established*
Contains no GMOs, artificial colours, preservatives or flavours. Contains GLUTEN. Suitable for vegans. See allergens in bold.

Trans Resveratrol

View supplement label

Capsules Per Container: 90

Amount Per Capsule Amount %NRV
Trans Resveratrol 500mg *
from Japanese Knotweed, natural source
Nutrient Reference Value not established*
Suitable for vegans. Contains no fillers, GMOs, common allergens, artificial colours, preservatives or flavours.  

Storage & Stability

To maintain the potency and quality of your vitalityPRO mitochondria support bundle, store them in a cool (20°C-25°C), dry place, and away from light.

Quality Standards

Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015. Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Micro Quality Labs. You can view all testing certificates at www.vitality-pro.com/batch-testing.

Safety & Warnings

Magnesium Threonate

Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.

Interactions: Bisphosphonates are used to treat osteoporosis. Magnesium can interfere with the absorption of bisphosphonates if taken too closely together. It's generally recommended to take magnesium supplements at a different time of day than bisphosphonates to avoid this interaction. Some forms of antibiotics, especially quinolone antibiotics (like Ciprofloxacin) and tetracycline antibiotics, can have their absorption reduced by magnesium. To avoid this, take magnesium supplements at least 2 hours before or after the antibiotic. Magnesium has been shown to interfere with the absorption of thyroid medications including Levothyroxine, Liothyronine and Naturally Dessecated Thyroid (NDT) preparations. Aim to take magnesium supplements at least 2 hours away from any thyroid medication you may be taking.

If you are taking these medications or any other medication, please first speak with your doctor before adding Magnesium Threonate to your supplement regime.

For further information regarding any other potential drug and supplement interactions of Magnesium Threonate please see the ingredient profile on Drug Bank.* Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.

Pregnancy: If pregnant, consult your health professional before using this product.

*Drug Bank is an independent website that lists potential interactions between the ingredients in Magnesium Threonate and other medications and supplements. It may not, however, list all known possible interactions. If you are on any medications or supplements you feel may interact negatively with Magnesium Threonate please first speak with your doctor before using this product.

PQQ

Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.

Interactions: It is unclear whether or not PQQ interacts with any medications or not. PQQ does however, increase levels of anti-oxidants produced by the body, such as Glutathione, which may have a negative effect on certain chemo-therapeutics. If you are taking any chronic medications please or any other medication, please first speak with your doctor before adding PQQ to your supplement regime

For further information regarding any other potential drug and supplement interactions of PQQ please see the ingredient profile on Drug Bank.* Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.

Pregnancy: If pregnant, consult your health professional before using this product.

*Drug Bank is an independent website that lists potential interactions between the ingredients in PQQ and other medications and supplements. It may not, however, list all known possible interactions. If you are on any medications or supplements you feel may interact negatively with PQQ please first speak with your doctor before using this product.

Spermidine

Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.

Interactions: As of 10 November 2024, there are no known published direct interactions between Spermidine and other medications. However, this does not mean interactions do not exist. Spermidine is a supplement that can improve insulin sensitivity; if you take medications and/or other supplements to help manage your blood sugar, you should first speak with your doctor before adding Spermidine to your supplement regime.

For further information regarding any other potential drug and supplement interactions of Spermidine please see the individual ingredient profile on Drug Bank*. Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.

Pregnancy: If pregnant, consult your health professional before using this product.

*Drug Bank is an independent website that lists potential interactions between the ingredients in Spermidine and other medications and supplements. It may not, however, list all known possible interactions. If you are taking any medications or supplements you feel may interact negatively with Spermidine please first speak with your doctor before using this product.

Trans Resveratrol

Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.

Interactions: Trans-Resveratrol is known to inhibit members of the Cytochrome P450 class of enzymes. As a result, it may interfere with antiplatelet and anticoagulant medications such as Warfarin. Additionally, resveratrol is classed as a phytoestrogen, a plant molecule that can mimic the effects of oestrogen in the body. Therefore, individuals who are hormone replacement therapies should therefore consult with their doctors before adding resveratrol to their longevity protocols. If you are taking these medications or any other medication, please first speak with your doctor before adding Resveratrol to your supplement regime.

For further information regarding any other potential drug and supplement interactions of Trans-Resveratrol, please see the ingredient profile on Drug Bank.* Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.

Pregnancy: If pregnant, consult your health professional before using this product.

*Drug Bank is an independent website that lists potential interactions between the ingredients in Trans-Resveratrol and other medications and supplements. It may not, however, list all known possible interactions. If you are on any medications or supplements you feel may interact negatively with Trans-Resveratrol please first speak with your doctor before using this product.
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Key studies to consider

While individual results may vary due to personal health conditions, genetics, and lifestyle choices, we guarantee that the supplements you receive are made with ingredients of the highest purity, similar to those used in scientific studies, to ensure maximum results.

Magnesium Threonate

Red blood cell magnesium and chronic fatigue syndrome – Case-Control Study and Randomised Controlled Trial

Dosage: Intramuscular magnesium sulphate every week for 6 weeks

Outcome: Improvement in energy levels, emotional state, and pain

Summary: The study found that patients with chronic fatigue syndrome (CFS) have lower red cell magnesium levels. Treatment with magnesium improved symptoms such as energy, mood, and pain in CFS patients, with a significant difference compared to placebo.

Read more

  Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems – Randomised controlled trial

Dosage: 1 g/day magnesium L-threonate, , providing 75 mg elemental magnesium

Outcome: Daytime energy, alertness, productivity, and sleep quality

Summary: Magnesium L-threonate improved deep and REM sleep and led to higher daytime energy, mental alertness, and productivity compared with placebo, likely by supporting brain and mitochondrial energy metabolism.

Read more

 Magnesium and Fibromyalgia: A Literature Review – Literature Review

Dosage: Oral magnesium typically 300–600 mg/day

Outcome: Fatigue, pain, function, and energy-related symptoms in fibromyalgia.

Summary: Some studies suggest magnesium may support cellular energy (ATP) production and reduce fatigue, but results are mixed and evidence is not definitive.

Read more

PQQ

 Pyrroloquinoline Quinone (PQQ): Its impact on human health and potential benefits – Narrative Review

Dosage: Human studies cited include single doses of PQQ at 0.2 mg/kg body weight; commonly studied supplemental intakes in humans are typically ~10–20 mg/day.

Outcome: Effects of PQQ on mitochondrial function, energy production, fatigue, and metabolic health.

Summary: PQQ supports mitochondrial biogenesis and antioxidant defence, which can improve cellular energy production and reduce fatigue. Human and animal data suggest PQQ may help people feel less tired by improving how efficiently cells make ATP and handle oxidative stress.

Read more

  Efficacy and safety of a novel dietary pyrroloquinoline quinone disodium salt on muscle strength and physical function in healthy volunteers – Randomised, double-blind, placebo-controlled trial

Dosage: 21.5 mg/day pyrroloquinoline quinone (PQQ) disodium salt for 12 weeks

Outcome: Improved muscle strength and physical function, suggesting better energy production and reduced physical fatigue

Summary: Daily PQQ supplementation significantly improved leg strength, grip strength, and walking performance compared to placebo, with no safety issues reported, indicating improved muscular energy and reduced fatigue.

Read more

 Effects of Oral Supplementation with Pyrroloquinoline Quinone on Stress, Fatigue, and Sleep – Open-label human trial

Dosage: 20 mg PQQ daily for 8 weeks

Outcome: Reduced fatigue and improved energy, mood, and sleep quality

Summary: Daily PQQ intake significantly reduced fatigue and increased feelings of energy and vigour, alongside better sleep and stress scores in adults.

Read more

Spermidine

 Molecular basis of the ‘anti-aging’ effect of spermidine and other natural polyamines – Review

Outcome: Autophagy is the main way by which spermidine exerts health effects.

Summary: Spermidine, a natural polyamine, boosts autophagy and may also reduce inflammation, improve fat metabolism, and regulate cell growth and death by controlling the activity of the AMPK pathway to support healthy ageing.

Read more

 Spermidine is essential for fasting-mediated autophagy and longevity – Review

Outcome: Fasting increased spermidine levels across species, promoting autophagy and extending lifespan through spermidine-dependent mechanisms.

Summary: This study highlights the key role of spermidine in activating autophagy during fasting. By increasing spermidine levels, fasting enhances the body’s ability to clear damaged cells, improving longevity and reducing the risk of age-related diseases. Blocking spermidine production was shown to disrupt these benefits, revealing spermidine’s essential role in fasting-mediated health improvements.

Read more

Trans Resveratrol

 Effect of Resveratrol Supplementation on Inflammatory Markers – A Systematic Review and Meta-analysis of Randomised Controlled Trials

Dosage: Mixed

Outcome: Reduction in levels of TNF-α and hs-CRP, two markers of inflammation

Summary: This study found that taking resveratrol can help lower certain signs of inflammation in the body. This suggests resveratrol might be useful alongside other treatments for diseases linked to inflammation.

Read more

 The Role and Mechanism of SIRT1 in Resveratrol-regulated Osteoblast Autophagy in Osteoporosis Rats – Animal study

Dosage: 5 mg/kg/day and 45 mg/kg/day resveratrol for 8 weeks

Outcome: Resveratrol improved bone density and promoted autophagy in bone cells through SIRT1 activation.

Summary: High-dose resveratrol activated SIRT1 and enhanced mitophagy in osteoblasts, protecting against bone loss in osteoporosis rats.

Read more

 Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury – Experimental Animal & Cell Study

Dosage: 40 mg/kg resveratrol daily in aged mice for 6 months; 50 μM resveratrol in HK2 kidney cells (in vitro).

Outcome: Resveratrol activates Nrf2 and increases antioxidant defences, reducing oxidative stress and kidney damage linked to ageing.

Summary: Resveratrol increased Nrf2 activity and its downstream antioxidants (HO-1, NQO-1, SOD1/2), which lowered oxidative stress and improved age-related kidney damage in mice. Blocking Nrf2 stopped these protective effects, showing Nrf2 is central to resveratrol’s action.

Read more

Everything You Need To Know About Energy Support Bundle

Alex Manos’ energy support bundle is designed to aid cellular energy production by supporting the health and function of the mitochondria, cell components that work to create ATP, the energy currency that runs the human body.

Products:

● Magnesium Threonate
● PQQ
● Spermidine
● Trans Resveratrol

Consider the following statements. If you find one or more relatable, Alex’s Mitochondrial support bundle might be the support you’ve been searching for:

  • I have read that dysfunctional mitochondria are one of the main reasons we age. I am looking to support my mitochondria so as to slow my rate of ageing.
  • Despite sleeping 7-8 hours a night I do not have the energy I need to get through the day and am looking for products to help.
  • My practitioner recommended these products to me.
  • I am an athlete looking to improve my physical performance and recovery. I have learnt that increasing mitochondrial density is one way to achieve these goals and I would like to trial this bundle for this purpose.
Made to GMP Standards
ISO 9001 Certified UK Company
Independent Testing for Purity

Transparent Testing

Every batch is independently tested for identity, potency, contaminants, heavy metals, and microbial markers.

View all product tests

Energy Support Bundle test results

Please see our product testing page for the most up-to-date testing on each product.

You can find our product testing page here.

Alex Manos BSc MSc NASM IFMCP is one of the few Institute for Functional Medicine Certified Practitioners in the UK. He has a master’s degree in Personalised Nutrition, for which he completed his dissertation on cortisol resistance in chronic fatigue syndrome. Alex also has a first-class degree in Nutritional Therapy and has completed Dr Siebecker’s certification in SIBO treatment.rnrnAway from his one-to-one work with clients, Alex lectures at various institutions and has been a clinical supervisor and mentor in the health and fitness industry.

Frequently Asked Questions

If you are new to these products we suggest that you layer them in one at a time to see how you tolerate each one. There is no right order however we suggest that you follow the guidelines under the ‘recommended use’ section of this page.

Creatine is an excellent addition to this bundle. Alex chose not to include as he finds the other products in this bundle are effective at helping to support mitochondria. If you would like to add creatine to this bundle you are welcome to do so and can find vitalityPRO’s Creapure product here.

Mould illness is a complex disease that requires both a holistic approach and time to recover.We recommend that you trial the bundle for at least 60 days. That said many people do start to notice an uptick in energy after a few weeks of using the products.

Mitochondria are your cells’ energy powerhouses. When they malfunction, every system suffers—especially high-energy organs like the brain, muscles, and heart. Supporting mitochondrial health requires providing the right fuel, nutrients, and signals to optimise energy production.

Circadian Rhythm

Mitochondria function according to circadian rhythms—their efficiency peaks and troughs throughout the day. Morning light exposure and consistent sleep-wake timing optimise mitochondrial biogenesis (creation of new mitochondria) and function. Poor circadian health directly impairs cellular energy production and increases oxidative stress. Prioritise 7-9 hours of quality sleep when mitochondrial repair and regeneration peak.

Diet: Local, Seasonal Whole Foods

Mitochondria require specific nutrients to produce ATP (cellular energy). Whole foods provide these in bioavailable forms: B vitamins (energy metabolism), magnesium (ATP production), CoQ10 (electron transport chain), and iron (oxygen transport). Seasonal produce offers peak nutrient content. Minimise processed foods, which lack these critical cofactors and burden mitochondria with inflammatory compounds. A Meditaerean diet is a good framework to operate from.

Omega-3 Fats

Omega-3s are incorporated into mitochondrial membranes, improving their fluidity and function. They also reduce oxidative stress and inflammation that damage mitochondria. Include fatty fish, grass-fed meat, pastured eggs, and plant sources like walnuts and flaxseeds. Adequate omega-3 intake supports mitochondrial biogenesis.

Polyphenols

Polyphenols activate cellular pathways (like PGC-1α) that stimulate mitochondrial biogenesis and protect existing mitochondria from oxidative damage. Green tea (EGCG), resveratrol (berries, grapes), quercetin (onions, apples), and curcumin (turmeric) are particularly beneficial. These compounds essentially signal your body to make more, healthier mitochondria.

Dietary Diversity

Different foods provide different mitochondrial cofactors. Variety ensures comprehensive nutrient coverage: leafy greens (magnesium, folate), organ meats (CoQ10, B vitamins), nuts and seeds
(vitamin E, selenium), colourful vegetables (antioxidants). A diverse gut microbiome also produces metabolites like butyrate that fuel mitochondria, particularly in the gut lining.

Exercise: Non-Negotiable for Mitochondrial Health

Exercise is the most powerful stimulus for mitochondrial biogenesis—it signals your body to create new, efficient mitochondria. However, the approach must match your current capacity. For those with significant dysfunction, start with very gentle, short-duration activities: 5-10 minutes of walking, light stretching, or low-resistance cycling. The key is consistency, not intensity initially. As tolerance builds, gradually incorporate higher-intensity intervals, which particularly stimulate mitochondrial adaptation. Both aerobic exercise (builds mitochondrial density) and resistance training (builds muscle mass and metabolic capacity) are valuable. Without exercise, mitochondrial recovery will be limited—movement is the primary signal that tells your body to invest in energy infrastructure. If starting from severe dysfunction, increase duration before intensity, and allow adequate recovery between sessions.

Gut Health

The gut microbiome profoundly influences mitochondrial function through multiple mechanisms: producing short-chain fatty acids that fuel colonocytes’ mitochondria, modulating systemic inflammation, synthesising vitamins (B12, K2), and influencing nutrient absorption. Dysbiosis can impair mitochondrial function throughout the body. Support gut health with fermented foods, diverse fiber sources, and adequate hydration. Addressing gut health often yields improvements in systemic energy levels.

Stress Management & Nervous System Support

Chronic stress directly damages mitochondria through cortisol dysregulation and oxidative stress. It also diverts resources from repair to survival mode. Practice daily stress reduction: meditation, breathwork, time in nature, or activities that genuinely restore you. Sleep quality is critical—mitochondrial repair peaks during deep sleep. Consider adaptogenic herbs (ashwagandha, rhodiola) under practitioner guidance. Balancing your nervous system creates the internal environment for mitochondrial healing.

Certainty of purity.

We are committed to the following quality controls to ensure consistency, reliability, and transparency in every product. Our goal is to raise industry standards and give you clear reasons to trust what you’re taking.
  • GMP Certified Facility

    All products are made to cGMP (current Good Manufacturing Practice) standards, the global benchmark for supplement quality. GMP standards ensure strict control over how our supplements are produced, covering everything from cleanliness to documentation and quality control. Every step is monitored to guarantee consistency and safety in every batch, so you receive the same high-quality product every time.

  • Third-Party Tested

    At the foundation of what we offer is certainty of product quality through consistent third-party testing, specifically for purity.

  • ISO Quality Managed

    ISO 9001:2015 standards are an internationally recognised framework for effective quality management. This accreditation means we follow a structured system of continuous improvement, always refining our processes to enhance product consistency and customer satisfaction. ISO accreditation ensures that every aspect of our operations, from production to customer service, is optimised. This means better oversight, reduced risk of errors, and a clear focus on delivering consistent results.

  • Transparency

    We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.

  • GMP Certified Facility

    Droplets

    Our supplements are manufactured in the UK, at facilities in Oxford and the North of England, following Good Manufacturing Practice (GMP) standards.

    GMP sets requirements for hygiene, production, quality control, and traceability, helping ensure supplements are consistently manufactured under controlled conditions.

    Our manufacturing partners hold independently issued GMP certificates. Rather than simply asking you to take our word for it, we've made these available below for you to review.

    Our UK Manufacturers' GMP Certificates

    Issued by Eurofins and SGS.

    Manufacturer 1

    Manufacturer 2

    Manufacturer names have been redacted for commercial confidentiality.

    Third-Party Tested

    Please see our product testing page for the most up-to-date testing on each product.

    You can find our product testing page here.

    ISO Quality Managed

    Vitality Pro is independently certified to ISO 9001:2015, an internationally recognised standard for quality management systems.

    Maintaining this certification requires ongoing monitoring, documented checks, regular reporting and independent audits. These processes help identify areas for improvement, ensure issues are addressed, and continually strengthen the systems and controls behind our supplements. It's a commitment to quality that must be demonstrated and maintained, not simply claimed.

    We believe quality should be independently verified, not simply claimed. You can view our ISO 9001:2015 certificate below.

    Our ISO 9001:2015 Certificate

    View Our Certificate

    Transparency

    We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.

    Transparency means we share all the details that matter—how our products are made, tested, and verified. From publishing third-party test results to offering clear ingredient labels, we provide you with the information you need to make informed choices about your supplements. Nothing is hidden, and every product comes with full accountability.

    In a world where many supplement companies keep you in the dark, we believe you deserve complete honesty. Being transparent allows you to trust that you’re getting exactly what you expect—pure, tested supplements without hidden risks. It’s about empowering you to make confident decisions and focus on your health journey without second-guessing the products you take.

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    Customs Fees: There may be customs to pay depending on your country’s local requirements. We will do what we can to avoid or minimise these as much as possible. If import charges are required, you will receive an email or text with customs clearance and payment instructions.

    Free Delivery: Available on orders over $300 USD.

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    60 Day Satisfaction Guarantee

    We want you to feel confident trying our products. If you're not satisfied for any reason, you can return your product within 60 days of receiving it for a full refund.

    This includes if you've changed your mind, haven't noticed the difference you hoped for, experienced side effects, or simply decided the product isn't right for you.

    How to claim the guarantee

    • Email returns@vitality-pro.com with your order number, which you'll find in your order confirmation email.
    • We'll send you the address to return your product to. Please include a note with your order number inside the parcel so we can identify your return.
    • Once your return is received, we'll process your refund within 7 days.

    Return shipping costs: You'll need to arrange and pay for return shipping unless the product arrived faulty or damaged. All returns are sent to our UK return address. If you're ordering from outside the UK, please keep in mind that international return shipping can be expensive.

    Multiple bottles or larger quantities: If you buy multiple bottles or a larger quantity of the same product in a single order, the guarantee covers the use of one bottle, or the smallest individual size supplied. Any additional unopened units must be returned to receive a refund.

    For example, if you order 180 capsules and receive 2 × 90-capsule bottles, you can open and use one 90-capsule bottle. The second bottle must be returned.

    The 60-Day Satisfaction Guarantee does not apply to our 100g NMN or 100g Resveratrol products, as we offer smaller 20g and 30g options to give you the opportunity to try the product before committing to a larger supply.

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