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Email: support@vitality-pro.com
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For general health and to support normal methylation take 1-2 capsules per day with water. TMG can be taken with or without food.
To support exercise performance, take your TMG dosage 30 minutes before your training session with your normal pre-workout nutrition. This may result in an increase in cellular hydration as well as an increase in levels of a molecule called nitric oxide, which helps to open up blood vessels and allow more oxygen to be delivered to target muscles.
| Amount Per Capsule | Amount | %NRV |
|---|---|---|
| Trimethylglycine (TMG) | 500mg | * |
| as Betaine Anhydrous |
Nutrient Reference Value not established*
Suitable for vegans. Contains no GMOs, common allergens, artificial colours, preservatives or flavours.
Date · Batch # · Results
Purity results include Heavy Metals
Previous results:
July 2025 · 2500299
98% Purity and Microbiology
December 2024 · BN2400713
95.1% Purity and Microbiology
April 2024 · BN262231006-2301376
100% Purity and Microbiology
December 2022 · TMG12082022
96.3% Purity
December 2021 · TMG11222021
100% Purity
Testing is carried out by Certified Labs (formerly Micro Quality Labs).
To maintain the potency and quality of your TMG supplements, store them in a cool (20°C-25°C), dry place and away from light.
Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015.
Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Micro Quality Labs. You can view all testing certificates at www.vitality-pro.com/batch-testing.
Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.
Interactions: There are no known published interactions between TMG and other medications at 10 November 2024. However, this does not mean interactions do not exist. TMG is used to lower levels of Homocysteine and may interfere with other similar medications. If you are taking these medications or any other medication, please first speak with your doctor before adding TMG to your supplement regime.
For further information regarding any other potential drug and supplement interactions with TMG, please see the individual ingredient profiles on Drug Bank using the link below.*
Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.
Pregnancy: If pregnant, consult your health professional before using this product.
*Drug Bank is an independent website that lists potential interactions between the ingredients in TMG and other medications and supplements. It may not, however, list all known possible interactions. If you are taking any medications or supplements that you feel may interact negatively with TMG, please speak with your doctor before using this product.
Trimethylglycine (TMG), also known as betaine, is a compound that supports methylation, altering molecular activity to help the body adapt to environmental changes and regulate essential processes.
For general health and to support normal methylation take 1-2 capsules per day with water. TMG can be taken with or without food.
To support exercise performance, take your TMG dosage 30 minutes before your training session with your normal pre-workout nutrition. This may result in an increase in cellular hydration as well as an increase in levels of a molecule called nitric oxide, which helps to open up blood vessels and allow more oxygen to be delivered to target muscles.
| Amount Per Capsule | Amount | %NRV |
|---|---|---|
| Trimethylglycine (TMG) | 500mg | * |
| as Betaine Anhydrous |
Nutrient Reference Value not established*
Suitable for vegans. Contains no GMOs, common allergens, artificial colours, preservatives or flavours.
Date · Batch # · Results
Purity results include Heavy Metals
Previous results:
July 2025 · 2500299
98% Purity and Microbiology
December 2024 · BN2400713
95.1% Purity and Microbiology
April 2024 · BN262231006-2301376
100% Purity and Microbiology
December 2022 · TMG12082022
96.3% Purity
December 2021 · TMG11222021
100% Purity
Testing is carried out by Certified Labs (formerly Micro Quality Labs).
To maintain the potency and quality of your TMG supplements, store them in a cool (20°C-25°C), dry place and away from light.
Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015.
Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Micro Quality Labs. You can view all testing certificates at www.vitality-pro.com/batch-testing.
Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.
Interactions: There are no known published interactions between TMG and other medications at 10 November 2024. However, this does not mean interactions do not exist. TMG is used to lower levels of Homocysteine and may interfere with other similar medications. If you are taking these medications or any other medication, please first speak with your doctor before adding TMG to your supplement regime.
For further information regarding any other potential drug and supplement interactions with TMG, please see the individual ingredient profiles on Drug Bank using the link below.*
Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.
Pregnancy: If pregnant, consult your health professional before using this product.
*Drug Bank is an independent website that lists potential interactions between the ingredients in TMG and other medications and supplements. It may not, however, list all known possible interactions. If you are taking any medications or supplements that you feel may interact negatively with TMG, please speak with your doctor before using this product.
Orders placed are shipped within 24 hours (Monday to Friday) from the UK.
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Customer Care | +44 (0) 1202 082 280 | support@vitality-pro.com
While individual results may vary due to personal health conditions, genetics, and lifestyle choices, we guarantee that the supplements you receive are made with ingredients of the highest purity, similar to those used in scientific studies, to ensure maximum results.
TMG (also known as betaine) supplies the body with methyl groups during methylation, supporting processes like DNA repair, gene regulation, and detoxification by converting homocysteine to methionine in the methylation cycle.
Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women – Randomised Controlled Trial
Dosage: Daily doses of 1.5, 3, and 6 grams of betaine for 6 weeks
Outcome: Reduced levels of plasma homocysteine, which is associated with lower risk of heart disease
Summary: Taking betaine was found to significantly lower the levels of homocysteine in the blood both immediately and over six weeks in healthy adults. This suggests that eating foods high in betaine or taking supplements could help reduce the risk of heart disease.
Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis – Meta-analysis
Intervention: At least 4 g/day of betaine for 6 to 24 weeks
Outcome: Reduction in plasma homocysteine levels by 1.23 μmol/L
Summary: Betaine supplementation at a dose of at least 4g/day for a minimum of 6 weeks significantly lowers plasma homocysteine levels in healthy adults, which could contribute to heart protection.
Effects of betaine on body composition, performance, and homocysteine thiolactone – Randomised Controlled Trial
Dosage: 2.5 grams of betaine daily for 6 weeks
Outcome: Changes in body composition, arm size, bench press performance, and a marker in the urine related to heart health
Summary: Betaine supplementation for 6 weeks helped improve body composition and arm size, increased bench press performance, and reduced a potentially harmful marker in the urine without significantly enhancing overall strength or power in experienced strength-trained men.
Effects of chronic betaine supplementation on performance in professional young soccer players during a competitive season – Randomised Controlled Trial
Dosage: 2 grams of betaine (also known as TMG) daily for 14 weeks
Outcome: Improvement in muscle strength, oxygen use during exercise, and ability to perform repeated sprints
Summary: Giving young professional soccer players betaine every day for 14 weeks helped them get stronger, use oxygen better during exercise, and do repeated sprints more effectively compared to those who didn’t take betaine.
Effects of Short-Term Betaine Supplementation on Muscle Endurance and Hormone Levels After Intense Exercise in Young Athletes – Double-Blind, Crossover Study
Dosage: 2.5 grams of betaine daily for 14 days
Outcome: Increased muscle endurance, lower stress hormone levels, and higher testosterone levels after intense exercise
Summary: Young handball players who took betaine for two weeks could do more repetitions in exercises and had better hormone levels indicating less stress and better muscle recovery compared to when they took a placebo.
Trimethylglycine (TMG), also known as betaine, is a derivative of the amino acid glycine. It is found naturally in the body and in certain foods, such as beetroot, spinach, and whole grains. TMG supports methylation, a biochemical process essential for cellular function and adaptation to the body’s changing demands.
TMG supports methylation by converting excess homocysteine into methionine. Through this process, TMG attaches a methyl group to homocysteine, forming methionine, which is then used to produce S-adenosylmethionine (SAMe), a key methyl donor which supports methylation by ensuring there are enough “methyl groups” to meet the body’s methylation demands.
Methylation modifies DNA by adding methyl groups to specific molecules in the body, turning certain genes on or off, and ensuring essential functions like repair and growth are active while silencing unnecessary processes for cell stability. In detoxification, methylation transforms toxins into safer, water-soluble compounds that the liver can then expel from the body. For neurotransmitter production, SAMe donates methyl groups to create serotonin and dopamine building blocks, thereby aiding in their formation. Additionally, by donating methyl groups to creatine precursors, methylation helps to increase creatine availability, supporting energy demands during high-intensity exercise.
Long-term NMN or NR use can deplete methyl groups because excess nicotinamide produced in the NMN-to-NAD cycle requires methylation for removal. This depletion might lead to fatigue in some individuals. TMG can help replenish these methyl groups, though it’s not necessary for everyone. If you experience fatigue with NMN or NR, it is recommended that you consider supplementing with TMG.
Healthy methylation supports essential bodily functions by adding or removing chemical groups (methyl groups) to activate or silence genes as needed. This is required for cell growth, repair, and the regulation of cellular functions. In a simple sense, methyl groups can be considered the fuel for methylation.
It is estimated that up to 70% of the population has a variant in the MTHFR gene, known as a polymorphism. The majority of these variants can lead to reduced methylation as they affect an enzyme essential for producing SAMe – the body’s primary methyl donor. Consult a healthcare professional if you have concerns about your MTHFR status.
Research suggests that methylation capacity declines with age, leading to impaired cellular function, inefficient detoxification, and increased homocysteine levels, all of which are linked to age-related decline. Supporting optimal methylation activity and keeping homocysteine levels within a healthy range may help support long-term cellular health.
Consider the statements below. If you find one or more relatable, TMG might be the supplement you’re looking for:
We are committed to the following quality controls to ensure consistency, reliability, and transparency in every product. Our goal is to raise industry standards and give you clear reasons to trust what you’re taking.
All products are made to cGMP (current Good Manufacturing Practice) standards, the global benchmark for supplement quality. GMP standards ensure strict control over how our supplements are produced, covering everything from cleanliness to documentation and quality control. Every step is monitored to guarantee consistency and safety in every batch, so you receive the same high-quality product every time.
Created by the US FDA, GMP regulations legally require manufacturers to ensure product safety, purity, and effectiveness. GMP minimises contamination, mix-ups, and errors, protecting consumers from ineffective or unsafe products.
GMP Guidelines Overview:
At the foundation of what we offer is certainty of product quality through consistent third-party testing, specifically for purity.
In an industry where many supplement providers cannot be fully certain of their product quality, third-party testing is essential to ensure purity and safety. This process removes uncertainty, so you can be confident that you’re taking supplements that are both safe and effective.
Every active ingredient in every batch of vitalityPRO products is independently tested by accredited laboratories to ensure unbiased analysis of purity.
Additional third-party testing screens for contaminants such as heavy metals, pesticides, and microbes, ensuring that each product is safe for consumption. Although certificates are provided by the manufacturer, this independent validation goes beyond standard testing, adding an extra layer of quality control.
Independent third-party testing ensures that you receive reliable, high-quality products every time.
ISO 9001:2015 standards are an internationally recognised framework for effective quality management. This accreditation means we follow a structured system of continuous improvement, always refining our processes to enhance product consistency and customer satisfaction. ISO accreditation ensures that every aspect of our operations—from production to customer service—is optimised. This means better oversight, reduced risk of errors, and a clear focus on delivering consistent results.
ISO 9001:2015 accreditation highlights a commitment to quality, customer satisfaction, and continuous improvement.
We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.
Transparency means we share all the details that matter—how our products are made, tested, and verified. From publishing third-party test results to offering clear ingredient labels, we provide you with the information you need to make informed choices about your supplements. Nothing is hidden, and every product comes with full accountability.
In a world where many supplement companies keep you in the dark, we believe you deserve complete honesty. Being transparent allows you to trust that you’re getting exactly what you expect—pure, tested supplements without hidden risks. It’s about empowering you to make confident decisions and focus on your health journey without second-guessing the products you take.
This TMG supplement is Betaine Anhydrous and will not raise stomach acid.
Yes, TMG is made in the body.
TMG is naturally found in foods such as beets, broccoli, shellfish, and spinach. However, due to the low amounts present in food, a supplement is likely the best option to receive the full benefits of TMG.
TMG supports methylation in the body. For some, TMG supplementation can lead to excess methylation, which can result in symptoms such as anxiety and fatigue. If you experience any of these symptoms, it is recommended that you stop taking TMG.
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