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Take either 1 or 2 scoops per day in the morning with a healthy, high-fat meal. This is equal to either 500mg or 1000mg of Trans-Resveratrol.
Trans-Resveratrol is fat-soluble, meaning it is best absorbed by the body when taken with a fat source. Healthy options for this include avocado, yoghurt, coconut or extra virgin olive oil.
| Amount Per Serving | Amount | %NRV |
|---|---|---|
| Trans-Resveratrol | 500mg | * |
| Micronised from Japanese Knotweed, natural |
Nutrient Reference Value not established*
Suitable for vegans. Contains no fillers, GMOs, common allergens, artificial colours, preservatives or flavours.
Date · Batch # · Results
Purity results include Heavy Metals
Previous results:
June 2025 · 2500226, 2401062
100% Purity
and Microbiology
September 2024 · BN2300594
99.8% Purity
and Microbiology
May 2023 · TRES12012023
99% Purity
December 2022 · T-RES12082022
98% Purity
Testing is carried out by Certified Labs (formerly Micro Quality Labs).
To maintain the potency and quality of your Resveratrol supplements, store them in a cool (20°C-25°C), dry place, and away from light.
Trans-Resveratrol must not be exposed to light for long periods as it will degrade to Cis-Resveratrol. Please store your Resveratrol in a dark environment.
Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015.
Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Micro Quality Labs. You can view all testing certificates at www.vitality-pro.com/batch-testing.
Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.
Interactions: Resveratrol is known to inhibit members of the Cytochrome P450 class of enzymes. As a result, it may interfere with antiplatelet and anticoagulant medications such as Warfarin. Additionally, resveratrol is classed as a phytoestrogen, a plant molecule that can mimic the effects of oestrogen in the body. Therefore, individuals who are hormone replacement therapies should therefore consult with their doctors before adding resveratrol to their longevity protocols. If you are taking these medications or any other medication, please first speak with your doctor before adding Resveratrol to your supplement regime.
For further information regarding any other potential drug and supplement interactions of Resveratrol please see the ingredient profile on Drug Bank.*
Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.
Pregnancy: If pregnant, consult your health professional before using this product.
*Drug Bank is an independent website that lists potential interactions between the ingredients in Trans-Resvertrol and other medications and supplements. It may not, however, list all known possible interactions. If you are on any medications or supplements you feel may interact negatively with Trans-Resvertrol please first speak with your doctor before using this product.
Trans-Resveratrol, in micronised powder form, is an antioxidant also believed to activate sirtuin genes responsible for activities most linked to longevity, such as DNA repair, metabolism, and stress response.
Take either 1 or 2 scoops per day in the morning with a healthy, high-fat meal. This is equal to either 500mg or 1000mg of Trans-Resveratrol.
Trans-Resveratrol is fat-soluble, meaning it is best absorbed by the body when taken with a fat source. Healthy options for this include avocado, yoghurt, coconut or extra virgin olive oil.
| Amount Per Serving | Amount | %NRV |
|---|---|---|
| Trans-Resveratrol | 500mg | * |
| Micronised from Japanese Knotweed, natural |
Nutrient Reference Value not established*
Suitable for vegans. Contains no fillers, GMOs, common allergens, artificial colours, preservatives or flavours.
Date · Batch # · Results
Purity results include Heavy Metals
Previous results:
June 2025 · 2500226, 2401062
100% Purity
and Microbiology
September 2024 · BN2300594
99.8% Purity
and Microbiology
May 2023 · TRES12012023
99% Purity
December 2022 · T-RES12082022
98% Purity
Testing is carried out by Certified Labs (formerly Micro Quality Labs).
To maintain the potency and quality of your Resveratrol supplements, store them in a cool (20°C-25°C), dry place, and away from light.
Trans-Resveratrol must not be exposed to light for long periods as it will degrade to Cis-Resveratrol. Please store your Resveratrol in a dark environment.
Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015.
Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Micro Quality Labs. You can view all testing certificates at www.vitality-pro.com/batch-testing.
Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.
Interactions: Resveratrol is known to inhibit members of the Cytochrome P450 class of enzymes. As a result, it may interfere with antiplatelet and anticoagulant medications such as Warfarin. Additionally, resveratrol is classed as a phytoestrogen, a plant molecule that can mimic the effects of oestrogen in the body. Therefore, individuals who are hormone replacement therapies should therefore consult with their doctors before adding resveratrol to their longevity protocols. If you are taking these medications or any other medication, please first speak with your doctor before adding Resveratrol to your supplement regime.
For further information regarding any other potential drug and supplement interactions of Resveratrol please see the ingredient profile on Drug Bank.*
Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.
Pregnancy: If pregnant, consult your health professional before using this product.
*Drug Bank is an independent website that lists potential interactions between the ingredients in Trans-Resvertrol and other medications and supplements. It may not, however, list all known possible interactions. If you are on any medications or supplements you feel may interact negatively with Trans-Resvertrol please first speak with your doctor before using this product.
Orders placed are shipped within 24 hours (Monday to Friday) from the UK.
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Customer Care | +44 (0) 1202 082 280 | support@vitality-pro.com
While individual results may vary due to personal health conditions, genetics, and lifestyle choices, we guarantee that the supplements you receive are made with ingredients of the highest purity, similar to those used in scientific studies, to ensure maximum results.
*The below research, carried out by Dr David Sinclair and others, suggests that Resveratrol may enhance the activity of SIRT1 through several mechanisms, such as mimicking the effects of caloric restriction. The pathways and the extent of how effectively Resveratrol can activate SIRT1 remain a topic of ongoing investigation.
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan – Cell Study
Dosage: Not specified
Outcome: Increased lifespan and DNA stability in yeast
Summary: Resveratrol, which boosts NAD+ and activates sirtuins, extended the lifespan of yeast cells by 70%, similar to the effects of calorie restriction. This suggests that NAD+ and sirtuin activation could promote longevity.
The Role and Mechanism of SIRT1 in Resveratrol-regulated Osteoblast Autophagy in Osteoporosis Rats – Animal study
Dosage: 5 mg/kg/day and 45 mg/kg/day resveratrol for 8 weeks
Outcome: Resveratrol improved bone density and promoted autophagy in bone cells through SIRT1 activation.
Summary: High-dose resveratrol activated SIRT1 and enhanced mitophagy in osteoblasts, protecting against bone loss in osteoporosis rats.
*Sirtuin 1 is a molecule that when activated has been shown to increase lifespan in both cell and mouse studies. While Resveratrol is believed to work by activating this molecule there is still debate in the longevity community about its efficacy of this.
Resveratrol Improves Health and Survival of Mice on a High-Calorie Diet – Preclinical Animal Study
Dosage: Resveratrol (dosage not specified)
Outcome: Increased lifespan and improved health markers in mice fed a high-calorie diet
Summary: In middle-aged mice, resveratrol improved general health and increased lifespan, mimicking the benefits of a standard diet. This was noted through several markers including better insulin sensitivity, lower levels of certain ageing-related factors, more mitochondria (energy-producing structures in cells) and enhanced physical ability.
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan – Cell Study
Dosage: Resveratrol, a compound found in red wine
Outcome: Extended lifespan of yeast by 70%
Summary: The study found that resveratrol can mimic the effects of eating less food to slow down ageing, leading to a significant increase in the lifespan of yeast. This suggests the potential benefits of resveratrol in promoting health and longevity.
Antioxidant effects of resveratrol in the cardiovascular system– Review
Outcome: Resveratrol acts as an indirect antioxidant by regulating genes, reducing ROS production, and up-regulating antioxidant enzymes.
Summary: Resveratrol appears to provide cardiovascular benefits mainly through its role as a gene regulator, decreasing ROS generation in mitochondria , rather than directly scavenging free radicals.
Antioxidant Effects of Resveratrol in Intervertebral Disk Degeneration – Review
Outcome: Resveratrol reduces oxidative stress by scavenging free radicals and supporting mitochondrial function.
Summary: Resveratrol acts as an antioxidant by reducing reactive oxygen species, which may slow the progression of intervertebral disk degeneration.
The Role of Resveratrol on Rheumatoid Arthritis: From Bench to Bedside – Review
Dosage: N/A
Outcome: The study assesses the potential benefits of resveratrol, a natural compound found in grapes and red wine, in treating rheumatoid arthritis (RA) by targeting inflammation and immune responses.
Summary: Resveratrol, known for its antioxidant properties, may help treat rheumatoid arthritis by reducing inflammation and protecting joints. Research suggests it could complement existing RA treatments, though more studies are needed to confirm its effectiveness and determine optimal dosages.
Effect of Resveratrol Supplementation on Inflammatory Markers – A Systematic Review and Meta-analysis of Randomised Controlled Trials
Dosage: Mixed
Outcome: Reduction in levels of TNF-α and hs-CRP, two markers of inflammation
Summary: This study found that taking resveratrol can help lower certain signs of inflammation in the body. This suggests resveratrol might be useful alongside other treatments for diseases linked to inflammation.
Resveratrol is a natural plant flavonoid found in red wine, grape skins, berries, and plants like Japanese Knotweed, a common supplement source. It is produced by plants in response to stress, injury, or pathogens as part of their defence system.
Micronised reseveratrol has been shown in one study to be up to 3.6 times more bioavailable than standard resveratrol.
Some research shows resveratrol activates sirtuins, particularly SIRT1, which supports cellular health and longevity by aiding DNA repair, metabolism, and stress response. SIRT1 also boosts mitochondrial numbers, enhancing energy output. Resveratrol is thought to boost sirtuin activity by promoting NAD+ binding to Sirtuins. It also activates AMPK, which regulates cellular energy, by simulating a low-energy state similar to fasting. AMPK activation has been shown to also activate sirtuins.
As an antioxidant, resveratrol neutralises ROS by donating electrons to them, stabilising them. It also influences the Nrf2 pathway, enabling Nrf2 to activate genes for antioxidant production, such as glutathione.
We are committed to the following quality controls to ensure consistency, reliability, and transparency in every product. Our goal is to raise industry standards and give you clear reasons to trust what you’re taking.
All products are made to cGMP (current Good Manufacturing Practice) standards, the global benchmark for supplement quality. GMP standards ensure strict control over how our supplements are produced, covering everything from cleanliness to documentation and quality control. Every step is monitored to guarantee consistency and safety in every batch, so you receive the same high-quality product every time.
Created by the US FDA, GMP regulations legally require manufacturers to ensure product safety, purity, and effectiveness. GMP minimises contamination, mix-ups, and errors, protecting consumers from ineffective or unsafe products.
GMP Guidelines Overview:
At the foundation of what we offer is certainty of product quality through consistent third-party testing, specifically for purity.
In an industry where many supplement providers cannot be fully certain of their product quality, third-party testing is essential to ensure purity and safety. This process removes uncertainty, so you can be confident that you’re taking supplements that are both safe and effective.
Every active ingredient in every batch of vitalityPRO products is independently tested by accredited laboratories to ensure unbiased analysis of purity.
Additional third-party testing screens for contaminants such as heavy metals, pesticides, and microbes, ensuring that each product is safe for consumption. Although certificates are provided by the manufacturer, this independent validation goes beyond standard testing, adding an extra layer of quality control.
Independent third-party testing ensures that you receive reliable, high-quality products every time.
ISO 9001:2015 standards are an internationally recognised framework for effective quality management. This accreditation means we follow a structured system of continuous improvement, always refining our processes to enhance product consistency and customer satisfaction. ISO accreditation ensures that every aspect of our operations—from production to customer service—is optimised. This means better oversight, reduced risk of errors, and a clear focus on delivering consistent results.
ISO 9001:2015 accreditation highlights a commitment to quality, customer satisfaction, and continuous improvement.
We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.
Transparency means we share all the details that matter—how our products are made, tested, and verified. From publishing third-party test results to offering clear ingredient labels, we provide you with the information you need to make informed choices about your supplements. Nothing is hidden, and every product comes with full accountability.
In a world where many supplement companies keep you in the dark, we believe you deserve complete honesty. Being transparent allows you to trust that you’re getting exactly what you expect—pure, tested supplements without hidden risks. It’s about empowering you to make confident decisions and focus on your health journey without second-guessing the products you take.
Healthy sirtuin activity supports cellular metabolism, DNA repair, and stress response, while effective antioxidant pathways limit oxidative damage, preserving cell function. Over time, sirtuin activity and antioxidant defences decline due to lower NAD levels, poor diet, stress, and exposure to toxins. Reduced sirtuin function and antioxidants weaken cellular repair and decrease overall cell protection. This decline increases oxidative stress and elevates reactive oxygen species (ROS), overwhelming the cell’s defences and causing chronic inflammation, DNA damage, and faster cellular ageing.
Around middle age (40–50 years), metabolism and cellular health decline, reducing sirtuin activity and antioxidant responses. Supporting these functions helps maintain mobility by protecting muscles and joints, promotes cognitive health by reducing neuroinflammation, and preserves cellular function, contributing to prolonged independence and resilience with age.
Consider the following statements. If any of the following statements apply to you, resveratrol could be the supplement you’re looking for:
Some research shows resveratrol activates sirtuins, particularly SIRT1, which supports cellular health and longevity by aiding DNA repair, metabolism, and stress response. SIRT1 also boosts mitochondrial numbers, enhancing energy output. Resveratrol is thought to boost sirtuin activity by promoting NAD+ binding to Sirtuins. It also activates AMPK, which regulates cellular energy, by simulating a low-energy state similar to fasting. AMPK activation has been shown to also activate sirtuins.
Olive oil, avocados and grass-fed dairy products such as yoghurt are examples of healthy fats you can take Resveratrol with.
Cis and trans resveratrol are two different isomers or shapes of the same resveratrol molecule. The trans form of resveratrol is more commonly found in nature and is better absorbed by the body (higher bioavailability) and is therefore the form used in supplements.
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