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Email: support@vitality-pro.com
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Take 1-2 capsules per day. This is equal to either 4mg or 8mg of Spermidine.
We recommend taking Advanced Spermidine after your last meal of the day to help the body transition into a state of autophagy between meals. This timing will also enhance the benefits of fasting.
| Amount Per Capsule | Amount | %NRV |
|---|---|---|
| Spermidine | >4mg | * |
| from Wheat Germ Extract, a natural source |
Nutrient Reference Value not established*
Contains no GMOs, artificial colours, preservatives or flavours. Contains GLUTEN.
Suitable for vegans. See allergens in bold.
Date · Batch # · Results
Purity results include Heavy Metals
Previous results:
May 2024 · BN10052024
0.947% Concentration*
*425mg capsule contains over 4mg Spermidine
September 2022 · SPER24082022
1.031% Concentration*
*400mg capsule contains over 4mg Spermidine
Testing is carried out by Sartorius Europe.
To maintain the potency and quality of your Spermidine supplements, store them in a cool (20°C-25°C), dry place and away from light.
Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015.
Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Micro Quality Labs. You can view all testing certificates at www.vitality-pro.com/batch-testing.
Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.
Interactions: As of 10 November 2024, there are no known published direct interactions between Spermidine and other medications. However, this does not mean interactions do not exist. Spermidine is a supplement that can improve insulin sensitivity; if you take medications and/or other supplements to help manage your blood sugar, you should first speak with your doctor before adding Spermidine to your supplement regime.
For further information regarding any other potential drug and supplement interactions of Spermidine please see the individual ingredient profile on Drug Bank*.
Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.
Pregnancy: If pregnant, consult your health professional before using this product.
*Drug Bank is an independent website that lists potential interactions between the ingredients in Spermidine and other medications and supplements. It may not, however, list all known possible interactions. If you are taking any medications or supplements you feel may interact negatively with Spermidine please first speak with your doctor before using this product.
Reformulated to remove zinc and thiamine – clients and practitioners requested a pure spermidine formula to avoid overlapping dosages with their own supplements. The result is a more versatile product, easier to combine with your personalised plans.
Spermidine is a naturally occurring molecule found in the body and in plants. It is known to stimulate autophagy, the body’s natural cellular renewal and recycling process, by mimicking the low-energy state induced by fasting or high-intensity exercise and activating AMPK.
Take 1-2 capsules per day. This is equal to either 4mg or 8mg of Spermidine.
We recommend taking Advanced Spermidine after your last meal of the day to help the body transition into a state of autophagy between meals. This timing will also enhance the benefits of fasting.
| Amount Per Capsule | Amount | %NRV |
|---|---|---|
| Spermidine | >4mg | * |
| from Wheat Germ Extract, a natural source |
Nutrient Reference Value not established*
Contains no GMOs, artificial colours, preservatives or flavours. Contains GLUTEN.
Suitable for vegans. See allergens in bold.
Date · Batch # · Results
Purity results include Heavy Metals
Previous results:
May 2024 · BN10052024
0.947% Concentration*
*425mg capsule contains over 4mg Spermidine
September 2022 · SPER24082022
1.031% Concentration*
*400mg capsule contains over 4mg Spermidine
Testing is carried out by Sartorius Europe.
To maintain the potency and quality of your Spermidine supplements, store them in a cool (20°C-25°C), dry place and away from light.
Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015.
Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Micro Quality Labs. You can view all testing certificates at www.vitality-pro.com/batch-testing.
Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.
Interactions: As of 10 November 2024, there are no known published direct interactions between Spermidine and other medications. However, this does not mean interactions do not exist. Spermidine is a supplement that can improve insulin sensitivity; if you take medications and/or other supplements to help manage your blood sugar, you should first speak with your doctor before adding Spermidine to your supplement regime.
For further information regarding any other potential drug and supplement interactions of Spermidine please see the individual ingredient profile on Drug Bank*.
Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.
Pregnancy: If pregnant, consult your health professional before using this product.
*Drug Bank is an independent website that lists potential interactions between the ingredients in Spermidine and other medications and supplements. It may not, however, list all known possible interactions. If you are taking any medications or supplements you feel may interact negatively with Spermidine please first speak with your doctor before using this product.
Orders placed are shipped within 24 hours (Monday to Friday) from the UK.
Need some advice?
Customer Care | +44 (0) 1202 082 280 | support@vitality-pro.com
While individual results may vary due to personal health conditions, genetics, and lifestyle choices, we guarantee that the supplements you receive are made with ingredients of the highest purity, similar to those used in scientific studies, to ensure maximum results.
Molecular basis of the ‘anti-aging’ effect of spermidine and other natural polyamines – Review
Outcome: Autophagy is the main way by which spermidine exerts health effects.
Summary: Spermidine, a natural polyamine, boosts autophagy and may also reduce inflammation, improve fat metabolism, and regulate cell growth and death by controlling the activity of the AMPK pathway to support healthy ageing.
Spermidine is essential for fasting-mediated autophagy and longevity – Review
Outcome: Fasting increased spermidine levels across species, promoting autophagy and extending lifespan through spermidine-dependent mechanisms.
Summary: This study highlights the key role of spermidine in activating autophagy during fasting. By increasing spermidine levels, fasting enhances the body’s ability to clear damaged cells, improving longevity and reducing the risk of age-related diseases. Blocking spermidine production was shown to disrupt these benefits, revealing spermidine’s essential role in fasting-mediated health improvements.
Spermidine and spermine are enriched in whole blood of nona/centenarians – Cross-sectional observational study
Outcome: Levels of polyamines (spermidine and spermine) were found in the blood of older individuals.
Summary: This study found that very old people (aged 90-106) have higher levels of certain healthy spermidine in their blood compared to younger groups. This suggests that polyamines may play a role in promoting a longer life.
Induction of Autophagy by Spermidine Promotes Longevity – Review
Outcome: Increased lifespan and reduced oxidative stress in various organisms
Summary: Spermidine supplementation was shown to significantly increase the lifespan of yeast, flies, worms, and even human immune cells by reducing damage from oxidative stress (a type of cell damage associated with ageing) and triggering a beneficial process called autophagy, which helps get rid of damaged cells.
Spermidine dietary supplementation and polyamines level in reference to survival and lifespan of honey bees – Randomised Controlled Trial
Dosage: 0.1 mM and 1 mM spermidine
Outcome: Increased survival rate, lifespan, and antioxidant capacity in honey bees.
Summary: Spermidine supplementation improved honey bee lifespan and survival by reducing oxidative stress and increasing antioxidant capacity.
New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases – Review
Outcome: Spermidine supplementation shows promise in delaying aging and extending lifespan by promoting autophagy, reducing inflammation, and supporting cell health.
Summary: This study highlights how spermidine can slow down the aging process and reduce age-related diseases by improving cellular health, boosting autophagy, and managing inflammation.
Spermidine intake is associated with cortical thickness and hippocampal volume in older adults – Cross-sectional Study
Dosage: Self-reported dietary intake assessed through a food frequency questionnaire
Outcome: Higher spermidine intake was linked to larger hippocampal volume and greater cortical thickness in brain areas affected by Alzheimer’s disease.
Summary: This study suggests that dietary spermidine may help protect brain structure, including memory-related regions, in older adults, making it a potential dietary approach for supporting brain health.
The effect of spermidine on memory performance in older adults at risk for dementia – Randomised Controlled Trial
Dosage: Spermidine-rich plant extract for 3 months, dosage not disclosed.
Outcome: Improved memory performance in older adults with subjective cognitive decline
Summary: Spermidine supplementation over three months moderately improved memory and discrimination ability in older adults at risk of dementia, suggesting its potential to support brain health by enhancing memory-related neural functions.
Spermidine is a naturally occurring polyamine found in all living cells, as well as in certain foods like wheat germ, soybeans, and aged cheese. It plays an important role in cell growth, division, and maintenance. Spermidine is also linked to cellular processes like autophagy, which helps remove damaged cell components and promotes cellular renewal.
Spermidine induces autophagy, a cellular process where damaged or dysfunctional components within the cell are broken down and recycled. Spermidine works by inhibiting enzymes like histone acetyltransferases, increasing cell stress resistance and triggering autophagy, primarily through activating AMPK, a key regulator of energy balance within cells. AMPK triggers autophagy as a survival response to low-energy conditions, enabling the body to generate and conserve energy in alternative ways. Through autophagy, unnecessary or damaged cell components are broken down and then recycled into new molecules for energy production. By clearing out damaged components, spermidine supports cellular health and longevity at the molecular level.
Healthy autophagy is the body’s way of removing and recycling damaged cell components, which keeps cells functioning efficiently and reduces the accumulation of dysfunctional cells. Autophagy declines with age due to lower cellular energy, weaker hormonal signals, and accumulated damage that disrupt autophagy pathways. This reduced autophagy allows damaged components to build up in cells, depleting cellular resources and accelerating age-related decline. Maintaining optimal Spermidine levels can help sustain autophagy, ensuring that cells continue to repair and renew themselves.
Spermidine promotes longevity by supporting autophagy, reducing cellular waste, and limiting accumulated cellular dysfunction. Studies show it aids cellular health, which is key to sustaining physical and cognitive ability as we age.
Consider the following statements. If you find one or more relatable, Spermidine might be the wellness support you’ve been searching for:
We are committed to the following quality controls to ensure consistency, reliability, and transparency in every product. Our goal is to raise industry standards and give you clear reasons to trust what you’re taking.
All products are made to cGMP (current Good Manufacturing Practice) standards, the global benchmark for supplement quality. GMP standards ensure strict control over how our supplements are produced, covering everything from cleanliness to documentation and quality control. Every step is monitored to guarantee consistency and safety in every batch, so you receive the same high-quality product every time.
Created by the US FDA, GMP regulations legally require manufacturers to ensure product safety, purity, and effectiveness. GMP minimises contamination, mix-ups, and errors, protecting consumers from ineffective or unsafe products.
GMP Guidelines Overview:
At the foundation of what we offer is certainty of product quality through consistent third-party testing, specifically for purity.
In an industry where many supplement providers cannot be fully certain of their product quality, third-party testing is essential to ensure purity and safety. This process removes uncertainty, so you can be confident that you’re taking supplements that are both safe and effective.
Every active ingredient in every batch of vitalityPRO products is independently tested by accredited laboratories to ensure unbiased analysis of purity.
Additional third-party testing screens for contaminants such as heavy metals, pesticides, and microbes, ensuring that each product is safe for consumption. Although certificates are provided by the manufacturer, this independent validation goes beyond standard testing, adding an extra layer of quality control.
Independent third-party testing ensures that you receive reliable, high-quality products every time.
ISO 9001:2015 standards are an internationally recognised framework for effective quality management. This accreditation means we follow a structured system of continuous improvement, always refining our processes to enhance product consistency and customer satisfaction. ISO accreditation ensures that every aspect of our operations—from production to customer service—is optimised. This means better oversight, reduced risk of errors, and a clear focus on delivering consistent results.
ISO 9001:2015 accreditation highlights a commitment to quality, customer satisfaction, and continuous improvement.
We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.
Transparency means we share all the details that matter—how our products are made, tested, and verified. From publishing third-party test results to offering clear ingredient labels, we provide you with the information you need to make informed choices about your supplements. Nothing is hidden, and every product comes with full accountability.
In a world where many supplement companies keep you in the dark, we believe you deserve complete honesty. Being transparent allows you to trust that you’re getting exactly what you expect—pure, tested supplements without hidden risks. It’s about empowering you to make confident decisions and focus on your health journey without second-guessing the products you take.
Spermidine is naturally found in foods such as wheat, legumes, and soy. However, due to the low amounts present in food, a supplement is likely the best option to receive the full benefits of Spermidine.
Spermidine is derived from wheat germ and contains trace amounts of gluten. consult their doctor before adding spermidine to their supplement protocols.
Spermidine can help the body more easily enter into a fasted state by increasing levels of the fasting enzyme AMPK, which is an energy-regulating molecule that helps the body enter into a state of autophagy.
We originally included small amounts of thiamine (vitamin B1) and zinc to support carbohydrate metabolism and immune function. However, many customers and practitioners preferred a pure spermidine formula to avoid overlapping dosages with their own supplements. The result is a more versatile product, easier to combine with personalised plans.
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