The Science Behind NMN–A Stable, Reliable NAD+ Activator and Anti-Aging Molecule – Article

NMN is a precursor to NAD+, a molecule that declines with age. Supplementation with NMN has shown promising results in raising NAD+ levels and improving insulin sensitivity, mitochondrial function, and overall energy metabolism, primarily in animal studies. Current research is exploring its potential benefits for human health and ageing.

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The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults – Randomised Controlled Trial

Dosage: 300 mg, 600 mg, or 900 mg NMN daily for 60 days
Outcome: Increase in blood NAD+ levels, with the highest levels seen in the 600 mg and 900 mg groups.
Summary: NMN supplementation safely increases NAD+ levels in healthy middle-aged adults, with the most effective dose being 600 mg daily. Participants taking NMN also showed better physical performance and stable biological age compared to placebo.

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The below research, carried out by Dr David Sinclair and others, suggests that Resveratrol may enhance the activity of SIRT1 through indirect mechanisms, such as mimicking the effects of caloric restriction, though the exact pathways and the extent of direct activation remain a topic of ongoing investigation.

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan – Cell Study

Dosage: Not specified
Outcome: Increased lifespan and DNA stability in yeast
Summary: Resveratrol, which boosts NAD+ and activates sirtuins, extended the lifespan of yeast cells by 70%, similar to the effects of calorie restriction. This suggests that NAD+ and sirtuin activation could promote longevity.

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The Role and Mechanism of SIRT1 in Resveratrol-regulated Osteoblast Autophagy in Osteoporosis Rats – Animal study

Dosage: 5 mg/kg/day and 45 mg/kg/day resveratrol for 8 weeks
Outcome: Resveratrol improved bone density and promoted autophagy in bone cells through SIRT1 activation.
Summary: High-dose resveratrol activated SIRT1 and enhanced mitophagy in osteoblasts, protecting against bone loss in osteoporosis rats.

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Resveratrol Improves Health and Survival of Mice on a High-Calorie Diet – Experimental Study

Dosage: Resveratrol (dosage not specified)
Outcome: Increased lifespan and improved health markers in mice fed a high-calorie diet
Summary: Resveratrol improved general health and increased lifespan in middle-aged mice, mimicking the benefits of a standard diet. This was noted through several markers, including better insulin sensitivity, lower levels of certain ageing-related factors, more mitochondria (energy-producing structures in cells), and enhanced physical ability.

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan – Laboratory Study

Dosage: Resveratrol, a compound found in red wine
Outcome: Extended lifespan of yeast by 70%
Summary: The study found that resveratrol can mimic the effects of eating less food to slow down ageing, leading to a significant increase in the lifespan of yeast. This suggests the potential benefits of resveratrol in promoting health and longevity.

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Clinical evaluation of changes in biomarkers by oral intake of NMN – Clinical Trial

Dosage: 300mg/day of NMN for 8 weeks
Outcome: Significant improvements in skin score and several health markers including NAM, adiponectin, BMI, and DHEA-s.
Summary: This study suggests NMN could be a safe and promising supplement for improving skin health and various biomarkers related to ageing and metabolism in postmenopausal women.

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A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults – Randomized Controlled Trial

Dosage: 300 mg of NMN daily for 60 days
Outcome: Increase in NAD+/NADH levels in the blood, indicating potential anti-ageing effects and improved energy levels.
Summary: This study tested a supplement called Uthever, aimed at slowing down ageing in adults aged 40 to 65. Taking NMN capsules every day for two months led to higher energy-related molecules in their bodies compared to those who took a placebo. The results suggest that Uthever could help people age more healthily by boosting energy at the cellular level and improving insulin sensitivity without significant side effects.

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Effect of Nicotinamide Mononucleotide on Brain Mitochondrial Respiratory Deficits in an Alzheimer’s Disease-Relevant Murine Model – Experimental Study

Dosage: Administration of NMN to mice genetically modified to develop Alzheimer’s-like symptoms
Outcome: Improved energy production in the brain cells of the treated mice, changes in the levels of certain proteins related to ageing and cell energy, and a shift in the balance of proteins controlling the shape and function of mitochondria (the cell’s powerhouse)
Summary: This study found that treating mice, designed to show symptoms similar to Alzheimer’s disease, with NMN improved the function of mitochondria in their brain cells. This suggests that NMN could potentially help counteract the energy production issues seen in Alzheimer’s disease by supporting the health of mitochondria and influencing the balance of proteins important for maintaining their structure and function.

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Resveratrol combats chronic diseases through enhancing mitochondrial quality – Review

Dosage: N/A
Outcome: Resveratrol helps improve mitochondrial function and may prevent or treat chronic diseases like Alzheimer’s, cardiovascular disease, obesity, and cancer.
Summary: Resveratrol enhances mitochondrial health, which plays a key role in combating chronic diseases. It works by reducing inflammation and oxidative stress, making it a potential strategy to improve cellular health and longevity.

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Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Adults – Randomized Controlled Trial

Intervention: 250 mg NMN or placebo, once daily for 12 weeks (morning or afternoon groups)
Outcome: Improved lower limb function (5-STS test) and reduced drowsiness (Jikaku-sho shirabe questionnaire) in the afternoon NMN group compared to baseline and other groups.
Summary: Afternoon NMN intake may improve physical performance and reduce drowsiness in older adults.

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Resveratrol Improves Hippocampal Atrophy in Chronic Fatigue Mice by Enhancing Neurogenesis and Inhibiting Apoptosis of Granular Cells – Animal Study

Intervention: Resveratrol (dose not specified) for 4 weeks
Outcome: Increased daily running activity by 20%, enlargement of the hippocampus
Summary: Resveratrol helped improve energy levels in fatigued mice by boosting brain health, increasing activity, and reducing cell death in the hippocampus.

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Created by the US FDA, GMP regulations legally require manufacturers to ensure product safety, purity, and effectiveness. GMP minimises contamination, mix-ups, and errors, protecting consumers from ineffective or unsafe products.

GMP Guidelines Overview:

• Manufacturing facilities must maintain a clean, hygienic environment in all areas, including labs and storage.
• Facility design, operations, and environmental conditions must prevent cross-contamination of drug products and materials.
• Manufacturing processes must be clearly defined, validated, and controlled to ensure consistency and compliance. Any process changes are evaluated for patient safety and product quality, with necessary validation.
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• Discrepancies are investigated and documented.
• Processes should remain controlled throughout the product life cycle, with improvements as needed.
  Records of manufacturing and distribution must be retained in an accessible format to trace the complete batch history.

At the foundation of what we offer is certainty of product quality through consistent third-party testing, specifically for purity.

In an industry where many supplement providers cannot be fully certain of their product quality, third-party testing is essential to ensure purity and safety. This process removes uncertainty, so you can be confident that you’re taking supplements that are both safe and effective.

Every active ingredient in every batch of vitalityPRO products is independently tested by accredited laboratories to ensure unbiased analysis of purity.

Additional third-party testing screens for contaminants such as heavy metals, pesticides, and microbes, ensuring that each product is safe for consumption. Although certificates are provided by the manufacturer, this independent validation goes beyond standard testing, adding an extra layer of quality control.

Independent third-party testing ensures that you receive reliable, high-quality products every time.

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Key Components of ISO 9001:2015

• Customer Focus: Meeting and exceeding customer needs and expectations.
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• Process Approach: Streamlining processes for efficiency and consistency.
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Implementing and Maintaining ISO 9001:2015

• Gap Analysis: Assessing current processes against ISO standards to identify needed improvements.
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• Employee Training: Ensuring all employees understand and follow quality management requirements.
• Internal Audits and Management Reviews: Regular audits to assess quality management effectiveness and address issues.
• External Audit for Accreditation: ISO-accredited body evaluates compliance.
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ISO 9001:2015 accreditation highlights a commitment to quality, customer satisfaction, and continuous improvement.

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Transparency means we share all the details that matter—how our products are made, tested, and verified. From publishing third-party test results to offering clear ingredient labels, we provide you with the information you need to make informed choices about your supplements. Nothing is hidden, and every product comes with full accountability.