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Email: support@vitality-pro.com
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Take 1–2 capsules daily. PQQ is water soluble, meaning it can be taken with or without food. Some suggest PQQ is optimally absorbed when taken on an empty stomach.
PQQ can be taken morning or evening—some report morning use boosts alertness, others prefer evening for cognitive support. Avoid taking it around resistance training, as its antioxidant effects may hinder muscle adaptation and recovery.
| Amount Per Capsule | Amount | %NRV |
|---|---|---|
| PQQ | 20mg | * |
| Pyrroloquinoline Quinone |
Nutrient Reference Value not established*
Suitable for vegans. Contains no GMOs, common allergens, artificial colours, preservatives or flavours.
Date · Batch # · Results
Purity results include Heavy Metals
Previous results:
December 2024 · BN 2400697
94.3% Purity and Microbiology
Testing is carried out by Certified Labs (formerly Micro Quality Labs).
To maintain the potency and quality of your PQQ supplements, store them in a refrigerator and away from light.
Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015.
Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by Eurofins and Microtech Wessex. You can view all testing certificates at www.vitality-pro.com/batch-testing.
Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.
Interactions: It is unclear whether or not PQQ interacts with any medications or not. PQQ does however increase levels of anti-oxidants produced by the body such as Glutathione which may have a negative effect on certain chemo-therapeutics. If you are taking any chronic medications please or any other medication, please first speak with your doctor before adding PQQ to your supplement regime
For further information regarding any other potential drug and supplement interactions of PQQ please see the ingredient profile on Drug Bank.*
Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.
Pregnancy: If pregnant, consult your health professional before using this product.
*Drug Bank is an independent website that lists potential interactions between the ingredients in PQQ and other medications and supplements. It may not, however, list all known possible interactions. If you are on any medications or supplements you feel may interact negatively with PQQ please first speak with your doctor before using this product.
PQQ is a naturally occurring powerful antioxidant studied for its ability to support cellular energy production and mitochondrial health.
*Not recommended for those with Long Covid.
Take 1–2 capsules daily. PQQ is water soluble, meaning it can be taken with or without food. Some suggest PQQ is optimally absorbed when taken on an empty stomach.
PQQ can be taken morning or evening—some report morning use boosts alertness, others prefer evening for cognitive support. Avoid taking it around resistance training, as its antioxidant effects may hinder muscle adaptation and recovery.
| Amount Per Capsule | Amount | %NRV |
|---|---|---|
| PQQ | 20mg | * |
| Pyrroloquinoline Quinone |
Nutrient Reference Value not established*
Suitable for vegans. Contains no GMOs, common allergens, artificial colours, preservatives or flavours.
Date · Batch # · Results
Purity results include Heavy Metals
Previous results:
December 2024 · BN 2400697
94.3% Purity and Microbiology
Testing is carried out by Certified Labs (formerly Micro Quality Labs).
To maintain the potency and quality of your PQQ supplements, store them in a refrigerator and away from light.
Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015.
Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by Eurofins and Microtech Wessex. You can view all testing certificates at www.vitality-pro.com/batch-testing.
Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.
Interactions: It is unclear whether or not PQQ interacts with any medications or not. PQQ does however increase levels of anti-oxidants produced by the body such as Glutathione which may have a negative effect on certain chemo-therapeutics. If you are taking any chronic medications please or any other medication, please first speak with your doctor before adding PQQ to your supplement regime
For further information regarding any other potential drug and supplement interactions of PQQ please see the ingredient profile on Drug Bank.*
Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.
Pregnancy: If pregnant, consult your health professional before using this product.
*Drug Bank is an independent website that lists potential interactions between the ingredients in PQQ and other medications and supplements. It may not, however, list all known possible interactions. If you are on any medications or supplements you feel may interact negatively with PQQ please first speak with your doctor before using this product.
Orders placed are shipped within 24 hours (Monday to Friday) from the UK.
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Customer Care | +44 (0) 1202 082 280 | support@vitality-pro.com
While individual results may vary due to personal health conditions, genetics, and lifestyle choices, we guarantee that the supplements you receive are made with ingredients of the highest purity, similar to those used in scientific studies, to ensure maximum results.
Effect of Dietary Pyrroloquinoline Quinone Disodium Salt on Cognitive Function in Healthy Volunteers: A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study – Randomised Controlled Trial
Dosage: 21.5 mg PQQ disodium salt for 12 weeks
Outcome: Improved memory, attention, reaction time, and overall cognitive function compared to placebo.
Summary: Taking 21.5 mg of PQQ daily for 12 weeks improved cognitive performance, including memory, attention, and flexibility, in healthy middle-aged and older adults without any side effects.
Pyrroloquinoline Quinone: a Novel Vitamin? – Review
Dosage: N/A
Outcome: PQQ shows potential to protect brain cells from damage and promote nerve growth factor (NGF) production, but it requires binding to glycine to work in the brain.
Summary: PQQ supports brain health by protecting against oxidative stress and enhancing NGF synthesis.
Pyrroloquinoline quinone disodium salt improves brain function in both younger and older adults – Double Blind Placebo Controlled Trial
Dosage: 20 mg PQQ daily for 12 weeks
Outcome: Improved cognitive function in younger adults (processing speed, executive speed, cognitive flexibility) at 8 weeks, and in older adults (composite and verbal memory) at 12 weeks.
Summary: PQQ supplementation supported brain health by improving specific cognitive abilities in both younger and older adults, with benefits appearing sooner in younger participants.
Pyrroloquinoline Quinone Modulates Mitochondrial Quantity and Function in Mice – Animal Study
Dosage: 2 mg PQQ/kg
Outcome: Increased mitochondrial quantity and improved mitochondrial efficiency.
Summary: Supplementing with PQQ significantly boosted the number of mitochondria and their functional capacity in mice.
Pyrroloquinoline quinone (PQQ) protects mitochondrial function of HEI-OC1 cells under premature senescence – Cell study
Dosage: 0.1 nanomole and 1.0 nanomole
Outcome: PQQ improved mitochondrial health by increasing energy production and protecting against oxidative stress in auditory cells.
Summary: Low doses of PQQ restored mitochondrial function in cells, prevented oxidative stress-induced damage and supported energy production through the activation SIRT1 and PGC-1α, two well known longevity molecules.
Metabolic and Biochemical Effects of Pyrroloquinoline Quinone (PQQ) on Inflammation and Mitochondrial Dysfunction: Potential Health Benefits in Obesity and Future Perspectives’ lifespan – Review
Dosage: 20 mg/day in human studies; 20 mg/kg/day in animal studies
Outcome: Improved mitochondrial function, reduced oxidative stress, and potential fat metabolism benefits.
Summary: PQQ supplementation may support energy production by improving mitochondrial biogenesis and reducing oxidative stress. This suggests that PQQ might support lifespan extension.
Pyrroloquinoline-Quinone Is More Than an Antioxidant: A Vitamin-like Accessory Factor Important in Health and Disease Prevention – Review
Dosage: 5–20 mg/day in human trials
Outcome: PQQ demonstrates potent antioxidant activity and supports mitochondrial function by enhancing NAD+-dependent enzymatic activity.
Summary: PQQ acts as a powerful antioxidant, efficiently neutralising reactive oxygen species and supporting mitochondrial health through sirtuin activation and improved NAD+ levels. It shows potential as a therapeutic nutraceutical.
Anti-inflammatory and Antioxidant Effects of Pyrroloquinoline Quinone in L-NAME-Induced Preeclampsia-Like Rat Model – Animal Study
Dosage: PQQ administered intraperitoneally (dose not specified).
Outcome: Improved antioxidant markers and reduced inflammation in preeclampsia-like rats.
Summary: PQQ protected against preeclampsia-like symptoms in rats by enhancing antioxidant activity through the NF-κB and Nrf2 pathways.
‘Recent progress in studies on the health benefits of pyrroloquinoline quinone’ – Review
Dosage: 0.2 mg/kg body weight in humans; 20 mg/kg body weight/day in rats for specific antioxidant studies.
Outcome: PQQ acts as a potent antioxidant, reducing oxidative stress and protecting cells from damage.
Summary: PQQ exhibits strong antioxidant activity, surpassing that of Vitamin C, and protects against oxidative damage in cells, tissues, and mitochondria.
Pyrroloquinoline quinone (PQQ) is a naturally occuring compound found in small amounts in foods such as dark chocolate, green tea and fermented foods such as miso. However, it is naturally produced by bacteria as it is used for it’s survival and growth.
PQQ is what is known as a “redox cofactor” in that is accepts electrons transforming into PQQH and donates them to molecules that need them.
PQQ works to increase energy by promoting the formation of new mitochondria, the power houses of the cell. It does this by activating proteins such as c-AMP and PGC-1 Alpha. These molecules work to increase the activity of so called ‘longevity molecules’ including SIRT1. These molecules then activate Tfam, a protein that increases mitochondria by attaching to DNA, allowing for existing mitochondria to be copied and produced.
In the brain PQQ is able to increase the production of nerve growth factor (NGF), a molecule that is important for both the growth and maintenance of brain cells. While the exact mechanism is not fully understood research suggests that PQQ might enhance the activity of COX enzymes. This leads to an increase in signalling molecules called prostaglandins. Higher levels of Prostaglandins are associated with increased levels of NGF and consequently improve cognitive function.
PQQ also works in the body as an antioxidant and is thought to be 100 more powerful than vitamin c. PQQ works as a direct antioxidant, helping to lower levels of harmful molecules called reactive oxygen species, protecting cells from the damage caused by high levels of oxygen. PQQ also increases the production of the body’s own antioxidant enzymes such as SOD and Catalase. These molecules are produced by cells and work in a similar way to PQQ, helping to further regulate levels of oxidative stress.
Consider the following statements. If one or more of them resonate with you, PQQ might be the cognitive and mitochondrial support you’ve been looking for:
We are committed to the following quality controls to ensure consistency, reliability, and transparency in every product. Our goal is to raise industry standards and give you clear reasons to trust what you’re taking.
All products are made to cGMP (current Good Manufacturing Practice) standards, the global benchmark for supplement quality. GMP standards ensure strict control over how our supplements are produced, covering everything from cleanliness to documentation and quality control. Every step is monitored to guarantee consistency and safety in every batch, so you receive the same high-quality product every time.
Created by the US FDA, GMP regulations legally require manufacturers to ensure product safety, purity, and effectiveness. GMP minimises contamination, mix-ups, and errors, protecting consumers from ineffective or unsafe products.
GMP Guidelines Overview:
At the foundation of what we offer is certainty of product quality through consistent third-party testing, specifically for purity.
In an industry where many supplement providers cannot be fully certain of their product quality, third-party testing is essential to ensure purity and safety. This process removes uncertainty, so you can be confident that you’re taking supplements that are both safe and effective.
Every active ingredient in every batch of vitalityPRO products is independently tested by accredited laboratories to ensure unbiased analysis of purity.
Additional third-party testing screens for contaminants such as heavy metals, pesticides, and microbes, ensuring that each product is safe for consumption. Although certificates are provided by the manufacturer, this independent validation goes beyond standard testing, adding an extra layer of quality control.
Independent third-party testing ensures that you receive reliable, high-quality products every time.
ISO 9001:2015 standards are an internationally recognised framework for effective quality management. This accreditation means we follow a structured system of continuous improvement, always refining our processes to enhance product consistency and customer satisfaction. ISO accreditation ensures that every aspect of our operations—from production to customer service—is optimised. This means better oversight, reduced risk of errors, and a clear focus on delivering consistent results.
ISO 9001:2015 accreditation highlights a commitment to quality, customer satisfaction, and continuous improvement.
We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.
Transparency means we share all the details that matter—how our products are made, tested, and verified. From publishing third-party test results to offering clear ingredient labels, we provide you with the information you need to make informed choices about your supplements. Nothing is hidden, and every product comes with full accountability.
Some users, especially those with long COVID or chronic fatigue, report further fatigue, aches, and discomfort after taking PQQ. One theory suggests that PQQ may lower glutathione levels by entering a cycle of donating and accepting electrons with it. This effect is more likely for those with compromised antioxidant systems or mitochondrial dysfunction. Others speculate that PQQ might interfere with endorphin pathways, leading to heightened pain sensitivity and exhaustion. These experiences highlight the importance of monitoring individual responses.
Research indicates that taking PQQ alongside CoQ10 can lead to greater improvements in cognitive function compared to taking either supplement alone. This synergy is thought to stem from their combined support of mitochondrial health.
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