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For best results, take 1-2 capsules daily in the morning on an empty stomach. This is 300 – 600mg of Nicotinamide Riboside.
Clinical studies show that daily NR increases NAD levels in a dose-dependent manner, meaning higher doses lead to greater increases in NAD.
We recommend taking NR in the morning to align with the body’s natural NAD production cycle.
| Amount Per Capsule | Amount | %NRV |
|---|---|---|
| Nicotinamide Riboside | 300mg | * |
| as Nicotinamide Riboside Chloride |
Nutrient Reference Value not established*
Suitable for vegans. Contains no fillers, GMOs, common allergens, artificial colours, preservatives or flavours.
Date · Batch # · Results
Purity results include Heavy Metals
Previous results:
December 2024 · BN2400775
98.9% Purity and Microbiology
May 2024 · NR231203
100% Purity
September 2023 · NR09062023
100% Purity
April 2023 · NR04202023
98.5% Purity
December 2022 · NR12082022
100% Purity
April 2022 · NR03172022
100% Purity
January 2021 · NR01062021
99% Purity
Testing is carried out by Certified Labs (formerly Micro Quality Labs).
To maintain the potency and quality of your NR supplements, store them in a cool (20°C-25°C), dry place and away from light.
If you plan to keep your NR supplement for over three months, you may want to refrigerate it to maintain maximum potency. Ensure the lid is tightly secured to prevent moisture from entering.
Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015.
Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Micro Quality Labs. You can view all testing certificates at www.vitality-pro.com/batch-testing.
Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.
Interactions: As of 10 November 2024, there are no known interactions between NR and other medications. However, NR is a form of Vitamin B3 (Niacin) that is known to interact with certain anti-seizure and blood-thinning medications. If you are taking these medications or any other medication, please speak with your doctor before adding NR to your supplement regime.
For further information regarding any other potential drug and supplement interactions with Nicotinamide Riboside (NR), please see the ingredient profile on Drug Bank using the link below.*
Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.
Pregnancy: If pregnant, consult your health professional before using this product.
*Drug Bank is an independent website that lists potential interactions between the ingredients in NR and other medications and supplements. It may not, however, list all known possible interactions. If you are taking any medications or supplements that you feel may interact negatively with NR, please speak with your doctor before using this product.
NR is taken to increase NAD+ levels, a molecule linked to improved cellular energy, function, health, and longevity.
For best results, take 1-2 capsules daily in the morning on an empty stomach. This is 300 – 600mg of Nicotinamide Riboside.
Clinical studies show that daily NR increases NAD levels in a dose-dependent manner, meaning higher doses lead to greater increases in NAD.
We recommend taking NR in the morning to align with the body’s natural NAD production cycle.
| Amount Per Capsule | Amount | %NRV |
|---|---|---|
| Nicotinamide Riboside | 300mg | * |
| as Nicotinamide Riboside Chloride |
Nutrient Reference Value not established*
Suitable for vegans. Contains no fillers, GMOs, common allergens, artificial colours, preservatives or flavours.
Date · Batch # · Results
Purity results include Heavy Metals
Previous results:
December 2024 · BN2400775
98.9% Purity and Microbiology
May 2024 · NR231203
100% Purity
September 2023 · NR09062023
100% Purity
April 2023 · NR04202023
98.5% Purity
December 2022 · NR12082022
100% Purity
April 2022 · NR03172022
100% Purity
January 2021 · NR01062021
99% Purity
Testing is carried out by Certified Labs (formerly Micro Quality Labs).
To maintain the potency and quality of your NR supplements, store them in a cool (20°C-25°C), dry place and away from light.
If you plan to keep your NR supplement for over three months, you may want to refrigerate it to maintain maximum potency. Ensure the lid is tightly secured to prevent moisture from entering.
Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015.
Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Micro Quality Labs. You can view all testing certificates at www.vitality-pro.com/batch-testing.
Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.
Interactions: As of 10 November 2024, there are no known interactions between NR and other medications. However, NR is a form of Vitamin B3 (Niacin) that is known to interact with certain anti-seizure and blood-thinning medications. If you are taking these medications or any other medication, please speak with your doctor before adding NR to your supplement regime.
For further information regarding any other potential drug and supplement interactions with Nicotinamide Riboside (NR), please see the ingredient profile on Drug Bank using the link below.*
Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.
Pregnancy: If pregnant, consult your health professional before using this product.
*Drug Bank is an independent website that lists potential interactions between the ingredients in NR and other medications and supplements. It may not, however, list all known possible interactions. If you are taking any medications or supplements that you feel may interact negatively with NR, please speak with your doctor before using this product.
Orders placed are shipped within 24 hours (Monday to Friday) from the UK.
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Customer Care | +44 (0) 1202 082 280 | support@vitality-pro.com
While individual results may vary due to personal health conditions, genetics, and lifestyle choices, we guarantee that the supplements you receive are made with ingredients of the highest purity, similar to those used in scientific studies, to ensure maximum results.
Nicotinamide Riboside (NR) is a form of vitamin B3 and a precursor to NAD+. It is a molecule that is involved in energy production and cellular repair. NR increases NAD+ levels by converting directly into NAD+ through a two-step process, bypassing complex pathways required by other precursors like nicotinamide or niacin.
A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment – Randomised Controlled Trial
Dosage: 1 g/day of NR for 10 weeks
Outcome: Increased blood NAD+ levels
Summary: In older adults with mild cognitive issues, taking a daily dose of NR increased a key blood component linked to energy but didn’t improve memory or thinking skills. Although it slightly altered blood flow in the brain, these changes weren’t clearly linked to any benefits or harms. The data suggest that the increased NAD is supportive of improved longevity outcomes.
Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives – Review
Dosage: NA
Outcome: The study explores the potential health benefits of Nicotinamide Riboside for ageing and longevity while highlighting the instability of NR and the improved stability offered by its borate-stabilized form.
Summary: Nicotinamide Riboside is a promising supplement for healthy ageing due to its role in NAD+ production.
Supplementation with Nicotinamide Riboside Reduces Brain Inflammation and Improves Cognitive Function in Diabetic Mice – Preclinical Animal Study
Dosage: NR for 6 weeks
Outcome: Reduced brain inflammation and improved memory and activity in diabetic mice
Summary: In diabetic mice, NR TNF-α and IL-6 (2 inflammatory molecules) helped reduce brain swelling, leading to improved memory and movement. This suggests that it could help treat memory problems by reducing brain inflammation.
Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients – Randomised Controlled Trial
Dosage: One dose of combined metabolic activators including 1000 mg/day of NR for 4 weeks
Outcome: Significant improvement in cognitive function as measured by a 29% improvement in AD Assessment Scale-cognitive subscale (ADAS-Cog) scores.
Summary: Alzheimer’s disease patients who received a special mixture of nutrients and compounds saw a notable improvement in their brain function and health, doing better on tests that measure thinking and memory compared to those who didn’t receive the mixture.
Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals – Randomised Controlled Trial
Dosage: NR supplementation, dosage not specified, before and 2 hours after taking the supplement
Outcome: Improved muscle strength during static exercises (isometric peak torque) and reduced fatigue in older adults
Summary: This study found that a single dose of NR, a supplement that may help correct antioxidant deficiencies, improved certain types of muscle strength and reduced fatigue in older adults but did not have the same beneficial effects in younger adults.
Nicotinamide riboside—a missing piece of the puzzle in exercise therapy in older adults? – Review
Dosage: Nicotinamide riboside (NR) supplementation; doses vary in animal and human studies (300-400 mg/kg in animals, up to 2000 mg/day in humans)
Outcome: The review discusses how NR might improve muscle function, endurance, and cardiovascular (CV) health, especially in older adults, but the results are inconsistent.
Summary: NR may enhance exercise benefits in older adults by improving energy production and muscle function.
NR, or Nicotinamide Riboside, is a form of Vitamin B3 (niacin) and a naturally occurring molecule in the body. It is a precursor or building block for the formation of nicotinamide adenine dinucleotide (NAD), a molecule essential for cellular energy production.
NR is converted in the body through a two-step process: first, it transforms into Nicotinamide Mononucleotide (NMN) and then into NAD.
The effectiveness of NAD precursors like NR (Nicotinamide Riboside) depends partly on their ability to enter cells efficiently. Compared to NMN (Nicotinamide Mononucleotide) and NAD (Nicotinamide Adenine Dinucleotide), NR is smaller and is therefore thought to enter cells more efficiently. Unlike larger molecules such as NMN, which often require specialised transporters, NR is believed to enter cells without assistance.
When NAD+ levels are optimal, cells function more efficiently, leading to improved energy, cognitive clarity, and better metabolism. As we age, NAD levels begin to decline. This is the result of a drop in the enzymes that help to produce NAD and an increase in the molecules that work to consume it. This drop in NAD results in cells being unable to create energy efficiently, affecting cellular repair processes and stress responses.
The accumulation of cellular damage is a hallmark of ageing, increasing the body’s demand to combat it. Studies indicate that supplementing with NR may assist in restoring and maintaining levels of NAD, leading to improved cellular function, cellular repair, and stress response as we age.
Evaluate each statement below. If you find one or more statements relatable, then NR could be the support you’ve been searching for:
We are committed to the following quality controls to ensure consistency, reliability, and transparency in every product. Our goal is to raise industry standards and give you clear reasons to trust what you’re taking.
All products are made to cGMP (current Good Manufacturing Practice) standards, the global benchmark for supplement quality. GMP standards ensure strict control over how our supplements are produced, covering everything from cleanliness to documentation and quality control. Every step is monitored to guarantee consistency and safety in every batch, so you receive the same high-quality product every time.
Created by the US FDA, GMP regulations legally require manufacturers to ensure product safety, purity, and effectiveness. GMP minimises contamination, mix-ups, and errors, protecting consumers from ineffective or unsafe products.
GMP Guidelines Overview:
At the foundation of what we offer is certainty of product quality through consistent third-party testing, specifically for purity.
In an industry where many supplement providers cannot be fully certain of their product quality, third-party testing is essential to ensure purity and safety. This process removes uncertainty, so you can be confident that you’re taking supplements that are both safe and effective.
Every active ingredient in every batch of vitalityPRO products is independently tested by accredited laboratories to ensure unbiased analysis of purity.
Additional third-party testing screens for contaminants such as heavy metals, pesticides, and microbes, ensuring that each product is safe for consumption. Although certificates are provided by the manufacturer, this independent validation goes beyond standard testing, adding an extra layer of quality control.
Independent third-party testing ensures that you receive reliable, high-quality products every time.
ISO 9001:2015 standards are an internationally recognised framework for effective quality management. This accreditation means we follow a structured system of continuous improvement, always refining our processes to enhance product consistency and customer satisfaction. ISO accreditation ensures that every aspect of our operations—from production to customer service—is optimised. This means better oversight, reduced risk of errors, and a clear focus on delivering consistent results.
ISO 9001:2015 accreditation highlights a commitment to quality, customer satisfaction, and continuous improvement.
We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.
Transparency means we share all the details that matter—how our products are made, tested, and verified. From publishing third-party test results to offering clear ingredient labels, we provide you with the information you need to make informed choices about your supplements. Nothing is hidden, and every product comes with full accountability.
In a world where many supplement companies keep you in the dark, we believe you deserve complete honesty. Being transparent allows you to trust that you’re getting exactly what you expect—pure, tested supplements without hidden risks. It’s about empowering you to make confident decisions and focus on your health journey without second-guessing the products you take.
Methylation is a vital biological process that influences how cellular functions are turned on or off to adapt to the body’s changing demands. Long-term NR use can cause depletion of methyl groups, as the excess nicotinamide generated during the NR to NAD production cycle needs methylation for its removal from the body. Depletion of these methyl groups may cause fatigue. TMG can aid in replenishing these methyl groups; however, it is not necessary for everyone. If you experience fatigue after taking NR, consider supplementing with TMG.
NAD levels have been shown to peak during the morning hours. We therefore suggest that you take your NR in the morning to match this natural daily rhythm. In some people, NR also has a stimulant-like effect, and for this reason, we suggest against taking it in the evening as it may result in poorer sleep quality.
Vitamin B3, also called Niacin, is the parent form of the molecule that your body uses to make NR. While this form of B3 can increase levels of NAD in cells, it is believed to be less efficient, which is why NR supplementation is recommended instead of niacin.
NR has been shown to be safe in doses of up to 2000 mg daily, however, these studies were controlled and their duration was short. NR has not been studied in dosages this high for long-term use. It is therefore recommended that you do not exceed 600 mg a day.
Recent manufacturing advancements have made NR more stable, reducing the need for refrigeration during short-term storage. However, for long-term storage, you may wish to refrigerate your NR to maintain maximum potency.
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