Fisetin
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Fisetin is a flavonoid, a unique class of polyphenols believed to prevent disease and encourage healthy ageing through potent antioxidant and anti-inflammatory effects, as well as its function as a senolytic. This compound may prevent age-related disease by promoting natural cellular senescence.
- Fisetin (100mg) per capsule
- 60 capsules per bottle
- Natural Fisetin derived from Cotinus Coggygria
- Third-party lab tested for purity – certificates attached
- Contains no GMOs, artificial colours, preservatives, flavours or allergens
- Suitable for vegans
- 100% biodegradable packaging
For best results, take 1-2 capsule per day with water, or as directed by your health care professional. This is equal to 100mg – 200mg of Fisetin.
Find out more about Fisetin by clicking here.
Additional ingredients: Vegetable Cellulose (Capsule), Microcrystalline Cellulose (100% Natural Filler)
*All Vitality Pro products are manufactured and third-party tested to GMP standards and ISO 9001:2015 quality certified.
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One of the most successful approaches to counteract ageing is clearing senescent cells, harmful cells from our body that can cause some age-related diseases.
A new triterpenoid compound from the flavonoid family, Fisetin, is thought to help clear these senescent cells from the body.
In a study by Unity Biotechnology with mice, scientists showed that Fisetin could clear senescent cells and has beneficial effects on health span.
Fisetin is absorbed quickly and completely after oral administration due to structural similarities to many dietary flavonoids like Quercetin or Kaempferol. This makes it likely that Fisetin will be perfectly able to pass through the gut barrier of humans.
The study’s scientists used a mouse model whose livers showed an age-related increase in liver scarring (fibrosis). They found that Fisetin ameliorates these changes and restores normal morphology even with such a short time frame. Dr Henning U. Lohmann, the Head of Research at Unity Biotechnology, who directed the study, said, “This type of treatment can reverse disease progression and has huge implications for patients suffering from chronic hepatic diseases”.
One other interesting observation made during the experiment was that Fisetin not only leads to the elimination of senescent cells but also makes young cells age slower. The scientists observed this in so-called “epithelial” cell cultures – which our organs are made of. These experiments also confirmed that Fisetin affects liver healthspan and fibrosis.
In conclusion, Fisetin is a promising senolytic, and it will be exciting to see whether this compound will become the next big thing in life extension.
Fisetin acts as a senotherapeutic by targeting critical genes involved in cellular senescence and ageing.
Reviews(18)
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I have previously been using Fisetin from another supplier but I really like the fact that this product has been Third Party Lab Tested at over 98% Purity and they are a ISO 9001:2015 UK Company which gives me confidence in the product quality. The packaging and product feel quality too compared to some other supplements I have used.
Having been interested in anti-ageing science for quite some time, I was pleased to come across a brand that produced the highest quality of Fisetin, which at the time of writing this review, is also the cheapest Fisetin supplement I’ve found.
This is the first product that I have ever purchased from Vitality Pro; I have not yet used the product in question, as I plan to start using it at a specific point in my health, fitness, and supplement regimen, but needless to say, I am confident that I will be repurchasing this item at a later date.
Vitality Pro does not have a lot of products in their catalogue, but what they do have is a carefully selected and refined range of products, meaning that whilst they do not have a lot of products, the few products which they do have in turn do a lot of work; I believe this is an important point to consider since just thinking about — and looking at — my evergrowing supplement stack is quite overwhelming.
Great quality and made from a trustworthy UK company who is ISO 9001:2015 Certified. Third Party Lab Testing at over 98% gives me confidence in this product. Fisetin is a very promising supplement for reducing senescence and anti aging with evidence to back it up. It’s early days for me with taking this so I’m looking forward to seeing results!
A high grade Fisetin, nice and yellow, from a UK based company with an awesome TrustPilot reputation
A good best buy date of >2 years in the future
I started using this product as soon as it arrived and it’s made such a big improvement to my overall wellbeing. I feel fantastic. I was researching living longer and fisetin was a name that kept coming up. Mainly extracted from Strawberries, it eliminates senescent cells and helps release new adult stem cells. This was the highest per mg and best price I found online. Highly recommended.
Promptly delivered by Vitality Pro. Fisetin is a powerful senolytic and this example is incredibly pure at 98%
I would strongly recommend this to anyone keen to rid themselves of the very harmful senescent cells that we all accumulate.
This is the first time I’ve purchased this product as it seems to be a relatively new kid on the block of supplements. I have been reading up on its anti-ageing/ anti-cancer activity and thought I would add it to my supplement regime. It’s to early to tell if it is having any effect at a cellular level, but I felt that the product was good quality by the packaging. I was also reassured by the quality reviews and the country of origin. It seems to be an established company, so imagine the product is as described and will be doing some good in my body.
I’ve used some other VP products before and knowing that they provide up to date lab reports have a high confidence in the quality of their product. I’ve been using this on a monthly basis at 20mg/kg body weight as per recent clinical trials from the Mayo Clinic, so 1800mg for me. Its only my second month so I cant really report back on the results but the trial is with a read. My dog is also on it and he does seem sprightlier, he’s quite elderly and especially since dog years are shorter than human he should show improvements before me. This monthly process works out quite good value for money especially when you compare to something like 1g of MNM a day. PS Dr David Sinclair says he’s been taking this for the last 2 years.
This supplement comes with a certificate of analysis from a reputable lab, and it certifies the potency and purity, not just the absence of contaminants, as many do. That lifts it above the rest for me.
Once you get into pricey supplements like NMN, resveratrol and fisetin, you really want to know what you are buying.
My first time trying Fisetin…
Difficult to know what you’re getting when you purchase supplements.
But so far so good…
I have taken 2 capsules per day for 10 days…
I don’t seem to have had any adverse reactions.
Generally it seems to have cleared some brain fog and my muscles seem to be aching less / feels like less inflammation in my body generally.
Combined with other supplements like Quercetin and it should improve the beneficial effects, but I haven’t tried doing this yet.
Overall I am satisfied.
1 star removed for price – more sellers should realise that if they make their prices more reasonable then they will have more customers / sales (and still make a decent profit longer term).
Maintaining good health using supplements can be very expensive. Many people who need to take supplements do so because their health is bad – and therefore probably their finances, as well.
It is important that more people have access to quality health supplements.
Overall this seems to be a good quality product.
I been taking for the last three weeks
Is improving my health, I’m planning to keep the good habit of taking it for the next year.
Reasonable price and I liked the fact that quality is tested by a 3rd party. The bottle is oversized for some reason, would be better for the environment that the bottle was smaller, and even better if it was glass and metal rather than plastic
Been taking this for a few weeks now and it does seem to be making a difference. My mind is sharper and my memory seems to have improved.
I am a young and spritely (!) man in my 70’s and this is the first time I’ve ever written a review for anything.
I have been taking this supplent for over 2 months now and I am quite sure that my mind has become sharper and my memory is improving. I take 2 capsules together each day at the same time on an empty stomach about 30 minutes after my morning coffee. I have read that it may be beneficial to take it with some sort of oil – so for me that oil is a 1000mg capsule of cod liver oil.
Hope this helps others who might be considering Fisetin for the same reasons.
After extensively researching the possible benefits of Fisetin, I gave it a try. After using it, I have decided to use a high dose (20-30 pills) for two days, every 8 weeks or so. Contrary to label information, I took 30 pills for two consecutive days. This “hit and run” approach to dosing is in line with some ongoing clinical trials at the moment. As this is a fairly new supplement, there is very little information on effective dosing. A few hours after taking my first dose, I started to feel very tired. My athletic performance dipped considerably. After a few days, I started to feel better and my athletic performance recovered above my previous level. Additionally, some aches and pains improved. For my next two day cycle, I will plan a few days of de-load training (light weights) during and after taking Fisetin. Vitality Pro seems to sell quality Fisetin backed up by recent independent lab analysis. As with all my supplements, I wouldn’t risk my health with “cheap” options. As for my background, I’m in my fifties, athletic, very fit and decently strong (e.g. deadlift 200kg at 80kg bodyweight). I’m not interested in any body recomposition, but want to maintain or improve my athletic performance and health.
I’ve taken this product in line with the Mayo clinic trials in which you take around 20mg per KG of body weight.
I’ve taken these over two days and felt some impact of this followed by feeling more clear in my thoughts, more motivated and slightly less achy overall. I will certainly be repeating this process every couple of months to keep up with the protocol.
Potentially honest product, but it is low dose to be useful. I’m not a doctor to advise, but if you are a biohacker and use fisetin for removing senescent cells, you ought to take 15-20 tables a day for 3-4 days to generate an effective cleansing. This product is potentially useful in that way.
I observed a positive effect while using this product. It is difficult to attribute my turnaround and wellness just to this product however.
I’ve been taking this with my other vitamins so can’t say specifically about this however one very big difference I noticed after taking this that when I was waking up in the morning I didn’t need to snooze my alarm multiple times and I didn’t require long lie ins during the weekends. As soon as I woke up I was ready and motivated to start my day early and felt energised in the morning before even having a cuppa which is unheard of for me.