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Take 2-4 capsules of Ca-AKG in the morning or as a split dose with 1 to 2 capsules in the morning and an additional one to two in the early afternoon. CaAKG can be taken with or without food.
CaAKG can have a mild stimulatory effect in some individuals. If you find it difficult to sleep, then it is advised that you take your full dose in the morning.
| Amount Per Capsule | Amount | %NRV |
|---|---|---|
| CaAKG | 500mg | * |
| Calcium Alpha-Ketoglutarate |
Nutrient Reference Value not established*
Suitable for vegans. Contains no GMOs, common allergens, artificial colours, preservatives or flavours.
Date · Batch # · Results
Purity results include Heavy Metals
Previous results:
November 2025 · 7023
90.7% Purity and Microbiology
April 2024 · CAK230905
98.1% Purity and Microbiology
July 2023 · CAAKG05152023
100% Purity
Testing is carried out by Certified Labs (formerly Micro Quality Labs).
To maintain the potency and quality of your CaAKG, store it in a cool (20°C-25°C), dry place away from light.
Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015.
Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Micro Quality Labs. You can view all testing certificates at www.vitality-pro.com/batch-testing.
Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.
Interactions: CaAKG contains calcium which may decrease the effects of calcium channel blocker medications, such as Nifedipine and Verapamil. If you are taking these medications or any other medication, please first speak with your doctor before adding CaAKG to your supplement regime
For further information regarding any other potential drug and supplement interactions with Calcium Alpha-Ketoglutarate (CaAKG), please see the ingredient profile on Drug Bank using the link below.*
Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.
Pregnancy: If pregnant, consult your health professional before using this product.
*Drug Bank is an independent website that lists potential interactions between the ingredients in CaAKG and other medications and supplements. It may not, however, list all known possible interactions. If you take any medications or supplements that may interact negatively with CaAKG, please speak with your doctor before using this product.
Calcium alpha-ketoglutarate (Ca-AKG) is a form of alpha-ketoglutarate, a molecule involved in cellular energy production. This form of AKG was used in a landmark longevity study on lifespan and age-related frailty.
Take 2-4 capsules of Ca-AKG in the morning or as a split dose with 1 to 2 capsules in the morning and an additional one to two in the early afternoon. CaAKG can be taken with or without food.
CaAKG can have a mild stimulatory effect in some individuals. If you find it difficult to sleep, then it is advised that you take your full dose in the morning.
| Amount Per Capsule | Amount | %NRV |
|---|---|---|
| CaAKG | 500mg | * |
| Calcium Alpha-Ketoglutarate |
Nutrient Reference Value not established*
Suitable for vegans. Contains no GMOs, common allergens, artificial colours, preservatives or flavours.
Date · Batch # · Results
Purity results include Heavy Metals
Previous results:
November 2025 · 7023
90.7% Purity and Microbiology
April 2024 · CAK230905
98.1% Purity and Microbiology
July 2023 · CAAKG05152023
100% Purity
Testing is carried out by Certified Labs (formerly Micro Quality Labs).
To maintain the potency and quality of your CaAKG, store it in a cool (20°C-25°C), dry place away from light.
Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015.
Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Micro Quality Labs. You can view all testing certificates at www.vitality-pro.com/batch-testing.
Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.
Interactions: CaAKG contains calcium which may decrease the effects of calcium channel blocker medications, such as Nifedipine and Verapamil. If you are taking these medications or any other medication, please first speak with your doctor before adding CaAKG to your supplement regime
For further information regarding any other potential drug and supplement interactions with Calcium Alpha-Ketoglutarate (CaAKG), please see the ingredient profile on Drug Bank using the link below.*
Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.
Pregnancy: If pregnant, consult your health professional before using this product.
*Drug Bank is an independent website that lists potential interactions between the ingredients in CaAKG and other medications and supplements. It may not, however, list all known possible interactions. If you take any medications or supplements that may interact negatively with CaAKG, please speak with your doctor before using this product.
Orders placed are shipped within 24 hours (Monday to Friday) from the UK.
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Customer Care | +44 (0) 1202 082 280 | support@vitality-pro.com
While individual results may vary due to personal health conditions, genetics, and lifestyle choices, we guarantee that the supplements you receive are made with ingredients of the highest purity, similar to those used in scientific studies, to ensure maximum results.
Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice
– Randomised Controlled Trial
Dosage: CaAKG at 2% w/w in diet starting at 18 months of age in mice – human equivalent is 15.1 mg per kilogram per day (For a 70 kg human, this would translate to about 15.1 mg/kg/day or a total daily dose of 1,059 mg)
Outcome: Extension of lifespan and reduction in frailty, with significant improvements in healthspan
Summary: CaAKG supplementation extended lifespan in female mice by up to 19.7% and significantly reduced frailty in both male and female mice.
Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test – Retrospective Analysis
Dosage: Two tablets of Rejuvant® containing 1 gram of CaAKG for 4 -10 months
Outcome: Average decrease in biological ageing of 8 years
Summary: This study found that taking a supplement called Rejuvant®, which contains alpha-ketoglutarate for about 7 months, can make your body’s biological clock show you’re about 8 years younger than before you started. It suggests this could be a way to potentially slow down the ageing process.
Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK – Research Study
Dosage: Up to 100 micromole of AKG per litre of solution
Outcome: Increased lifespan in fruit flies
Summary: Adding AKG to the diet of fruit flies extended their lifespan by turning on AMPK signalling and turning off mTOR pathways. It did not improve resistance to oxidative stress or starvation but did increase resistance to heat and activity of genes related to stress response.
Alpha-ketoglutarate as a potent regulator for lifespan and healthspan: Evidences and perspectives – Review
Dosage: 1000 mg Ca-AKG for 7 months (in humans)
Outcome: Increase in lifespan and healthspan across various models (C. elegans, Drosophila, mice, and implications for humans) due to alpha-ketoglutarate (AKG)
Summary: AKG shows potential as an anti-ageing compound by influencing various cellular processes, including energy metabolism and epigenetic regulation. Studies in animal models demonstrate that AKG supplementation can extend lifespan and improve healthspan, suggesting promising applications for delaying ageing and enhancing longevity in humans.
Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK – Experimental Study
Dosage – Up to 1000 micromoles of AKG per litre of solution
Outcome: Extended lifespan and increased heat stress resistance; decreased reproductive performance
Summary: Adding AKG to the diet of fruit flies increased their lifespan and improved their ability to resist heat stress. AKG worked by turning on a longevity-promoting signal (AMPK) and turning off a growth signal (mTOR) in the flies.
Alpha-Ketoglutarate Decreases Serum Levels of C-terminal Cross-Linking Telopeptide of Type I Collagen (CTX) in Postmenopausal Women with Osteopenia: Six-Month Study – Randomised Controlled Trial
Dosage: 6 g α-Ketoglutaric Acid (AKG) and 1.68 g Calcium daily for 6 months
Outcome: Change in bone breakdown markers and bone mineral density in the lower spine
Summary: AKG-Ca reduced bone breakdown, which may help protect bone health in postmenopausal women. The increase in bone density was small and not significant. More research is needed to confirm long-term benefits.
Alpha ketoglutarate exerts a pro-osteogenic effect in osteoblast cell lines through activation of JNK and mTOR/S6K1/S6 signaling pathways – Cell Study
Dosage: NA
Outcome: Improved markers of bone formation and increased mineral content in bone cells
Summary: Alpha-ketoglutarate helps bone-forming cells mature by activating certain pathways, showing potential as a treatment to strengthen bones and fight osteoporosis.
Alpha-Ketoglutarate (AKG) is a naturally occurring compound in the body and a key component of the Krebs cycle, the body’s main energy-producing pathway that converts food into useable energy within cells. Once nutrients enter the cell the cycle uses AKG to extract energy from them.
The Calcium Alpha-Ketoglutatrate (Ca-AKG) form of AKG is the molecule used in the 2020 landmark longevity study, which showed that AKG has a positive effect on reducing frailty and increasing lifespan.
Although AKG is a key component of the Krebs cycle, the benefits of supplementation are thought to have a dual role. The body typically produces enough AKG, and deficiencies are rare; however, AKG production declines with age. In addition to replenishing levels, externally supplied AKG has been studied for its ability to disrupt cellular energy balance, triggering a stress response that downregulates mTOR, a key regulator of growth and metabolism linked to accelerated ageing when overactivated.
The mTOR (mechanistic target of rapamycin) pathway is a major regulator of cell growth, protein creation, and energy consumption. When nutrient and energy levels are high, mTOR is activated, promoting growth processes. However, chronic mTOR activation accelerates ageing by driving excessive growth and reducing the cell’s ability to repair and resist stress.
Externally supplied AKG appears to have a dual effect on cellular energy. As well as ensuring the body has enough AKG to create cellular energy (ATP), it may inhibit limit enzymes responsible for the final step in ATP production. This inhibition reduces ATP levels, activating energy-conserving pathways such as AMPK, which in turn inhibits mTOR activity.
These pathways—AMPK and mTOR—are believed to be key mechanisms by which CaAKG supports longevity and bone health. It slows excessive growth, switches on cellular repair processes, and allows the body to better respond to stress.
Healthy AKG levels ensure efficient cellular energy production to power all essential cellular processes. General mitochondrial function decline and damage, slower metabolism and decreased muscle mass (a major source of AKG production) all contribute to decreases in AKG production over time. By maintaining healthy AKG levels, the body can efficiently produce energy, support cellular repair, and sustain healthy metabolism. Optimal AKG levels help the body function at its best.
In addition, healthy mTOR activation is a balanced, context-dependent response that promotes growth and repair when nutrients are abundant and deactivate during low-energy states to support cellular maintenance and stress resistance. However, mTOR can become overactive due to chronic overnutrition, such as excessive calorie and carbohydrate intake. Certain conditions like obesity, insulin resistance, and metabolic disorders further drive excessive mTOR activation. This overactivity can impair autophagy (the process of clearing damaged cells), reduce cellular repair, and increase oxidative stress.
Studies show that after age 40, Alpha-Ketoglutarate levels begin to decline, and supplementation can help counteract this drop, promoting optimal cellular function. A landmark longevity study demonstrated improved lifespan and reduced frailty in ageing mice, believed to be due to CaAKG’s ability to inhibit excessive mTOR activation, enhancing autophagy, cellular maintenance, and stress resistance, ultimately supporting healthier ageing and increased longevity.
Consider the following statements. If you find one or more relatable, CaAKG might be the support you’ve been searching for:
We are committed to the following quality controls to ensure consistency, reliability, and transparency in every product. Our goal is to raise industry standards and give you clear reasons to trust what you’re taking.
All products are made to cGMP (current Good Manufacturing Practice) standards, the global benchmark for supplement quality. GMP standards ensure strict control over how our supplements are produced, covering everything from cleanliness to documentation and quality control. Every step is monitored to guarantee consistency and safety in every batch, so you receive the same high-quality product every time.
Created by the US FDA, GMP regulations legally require manufacturers to ensure product safety, purity, and effectiveness. GMP minimises contamination, mix-ups, and errors, protecting consumers from ineffective or unsafe products.
GMP Guidelines Overview:
At the foundation of what we offer is certainty of product quality through consistent third-party testing, specifically for purity.
In an industry where many supplement providers cannot be fully certain of their product quality, third-party testing is essential to ensure purity and safety. This process removes uncertainty, so you can be confident that you’re taking supplements that are both safe and effective.
Every active ingredient in every batch of vitalityPRO products is independently tested by accredited laboratories to ensure unbiased analysis of purity.
Additional third-party testing screens for contaminants such as heavy metals, pesticides, and microbes, ensuring that each product is safe for consumption. Although certificates are provided by the manufacturer, this independent validation goes beyond standard testing, adding an extra layer of quality control.
Independent third-party testing ensures that you receive reliable, high-quality products every time.
ISO 9001:2015 standards are an internationally recognised framework for effective quality management. This accreditation means we follow a structured system of continuous improvement, always refining our processes to enhance product consistency and customer satisfaction. ISO accreditation ensures that every aspect of our operations—from production to customer service—is optimised. This means better oversight, reduced risk of errors, and a clear focus on delivering consistent results.
ISO 9001:2015 accreditation highlights a commitment to quality, customer satisfaction, and continuous improvement.
We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.
Transparency means we share all the details that matter—how our products are made, tested, and verified. From publishing third-party test results to offering clear ingredient labels, we provide you with the information you need to make informed choices about your supplements. Nothing is hidden, and every product comes with full accountability.
CaAKG is alpha-ketoglutarate bound to calcium, whereas other forms of alpha-ketoglutarate often use the amino acid arginine as a base. Studies suggest that binding with calcium may improve the absorption and effectiveness of alpha-ketoglutarate. CaAKG was also the form used in the landmark longevity study related to lifespan and age-related frailty.
CaAKG is not naturally found in foods, though alpha-ketoglutarate (AKG) does occur in small amounts in red meat, fish, and dairy products. Interestingly, ketogenic diets are thought to help conserve AKG levels in the body.
While there is no established upper limit for CaAKG, excessive amounts may cause gastrointestinal discomfort. CaAKG also contains calcium, which may not be suitable for individuals with kidney issues or those on long-term medications. We recommend consulting your healthcare provider before starting CaAKG if you are on any ongoing medications.
In mouse studies, CaAKG reduced fur greying, likely due to its protective effects on melanocytes (pigment-producing cells), its support for mitochondrial function, and its benefits for stem cell health. While further research and human studies are needed, these findings suggest that CaAKG may help reduce hair greying.
The best time to take CaAKG is typically in the morning, as it supports energy metabolism, to align with your body’s natural daytime activity and energy needs.
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