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For best results, take one capsule with each main meal (2-3 times per day). Alternatively, take two capsules with your largest carbohydrate-containing meal of the day.
This is equal to 500mg – 1500mg of Berberine HCl.
| Amount Per Capsule | Amount | %NRV |
|---|---|---|
| Berberine | 500mg | * |
| from Berberis Aristata, natural source | ||
| Milk Thistle Extract | 125mg | * |
| from Silybum Marianum, natural source |
Nutrient Reference Value not established*
Suitable for vegans. Contains no GMOs, common allergens, artificial colours, preservatives or flavours.
Date · Batch # · Results
Purity results include Heavy Metals
Previous results:
May 2025 · BN2401066
86% Purity and Microbiology
– Switched to granulated Berberine for improved manufacturing. Berberine originally +96% before granulation.
– Increased to 590mg Berberine per capsule to ensure 500mg Berberine per capsule.
April 2024 · BN20231011
87.5% Purity and Microbiology
September 2023 · BERB09062023
85.9% Purity
August 2022 · BERB06142022
99% Purity
May 2021 · BERB05062021
98.5% Purity
Testing is carried out by Certified Labs (formerly Micro Quality Labs).
To maintain the potency and quality of your Berberine supplements, store them in a cool (20°C-25°C), dry place and away from light.
Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015.
Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Certified Labs (formerly Micro Quality Labs). You can view all testing certificates at www.vitality-pro.com/batch-testing.
Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.
Interactions: Berberine is known to inhibit members of the Cytochrome P450 class of enzymes. As a result, it may interfere with antiplatelet and anticoagulant medications such as Warfarin. It has also been shown to interact with certain drugs that aim to control elevated blood pressure. Berberine may also interact with certain immunosuppressive drugs, such as Cyclosporine. Berberine should also not be combined with any pharmaceutical that helps to control sugar. If you are taking these medications or any other medication, please first speak with your doctor before adding Berberine to your supplement regime.
For further information regarding any other potential drug and supplement interactions with Advanced Berberine please see the ingredient profile on Drug Bank using the links below*.
Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.
Pregnancy: If pregnant, consult your health professional before using this product.
*Drug Bank is an independent website that lists potential interactions between the ingredients in Advanced Berberine and other medications and supplements. It may not, however, list all known possible interactions. If you are taking any medications or supplements that you feel may interact negatively with Advanced Berberine, please speak with your doctor before using this product.
Berberine is a natural plant compound. It has been studied for its ability to activate AMPK, an enzyme that encourages glucose uptake into cells.
For best results, take one capsule with each main meal (2-3 times per day). Alternatively, take two capsules with your largest carbohydrate-containing meal of the day.
This is equal to 500mg – 1500mg of Berberine HCl.
| Amount Per Capsule | Amount | %NRV |
|---|---|---|
| Berberine | 500mg | * |
| from Berberis Aristata, natural source | ||
| Milk Thistle Extract | 125mg | * |
| from Silybum Marianum, natural source |
Nutrient Reference Value not established*
Suitable for vegans. Contains no GMOs, common allergens, artificial colours, preservatives or flavours.
Date · Batch # · Results
Purity results include Heavy Metals
Previous results:
May 2025 · BN2401066
86% Purity and Microbiology
– Switched to granulated Berberine for improved manufacturing. Berberine originally +96% before granulation.
– Increased to 590mg Berberine per capsule to ensure 500mg Berberine per capsule.
April 2024 · BN20231011
87.5% Purity and Microbiology
September 2023 · BERB09062023
85.9% Purity
August 2022 · BERB06142022
99% Purity
May 2021 · BERB05062021
98.5% Purity
Testing is carried out by Certified Labs (formerly Micro Quality Labs).
To maintain the potency and quality of your Berberine supplements, store them in a cool (20°C-25°C), dry place and away from light.
Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015.
Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Certified Labs (formerly Micro Quality Labs). You can view all testing certificates at www.vitality-pro.com/batch-testing.
Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.
Interactions: Berberine is known to inhibit members of the Cytochrome P450 class of enzymes. As a result, it may interfere with antiplatelet and anticoagulant medications such as Warfarin. It has also been shown to interact with certain drugs that aim to control elevated blood pressure. Berberine may also interact with certain immunosuppressive drugs, such as Cyclosporine. Berberine should also not be combined with any pharmaceutical that helps to control sugar. If you are taking these medications or any other medication, please first speak with your doctor before adding Berberine to your supplement regime.
For further information regarding any other potential drug and supplement interactions with Advanced Berberine please see the ingredient profile on Drug Bank using the links below*.
Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.
Pregnancy: If pregnant, consult your health professional before using this product.
*Drug Bank is an independent website that lists potential interactions between the ingredients in Advanced Berberine and other medications and supplements. It may not, however, list all known possible interactions. If you are taking any medications or supplements that you feel may interact negatively with Advanced Berberine, please speak with your doctor before using this product.
Orders placed are shipped within 24 hours (Monday to Friday) from the UK.
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Customer Care | +44 (0) 1202 082 280 | support@vitality-pro.com
While individual results may vary due to personal health conditions, genetics, and lifestyle choices, we guarantee that the supplements you receive are made with ingredients of the highest purity, similar to those used in scientific studies, to ensure maximum results.
Efficacy and safety of HIMABERB® Berberine on glycemic control in patients with prediabetes: double-blind, placebo-controlled, and randomized pilot trial – Randomised Controlled Trial
Dosage: 500 mg of HIMABERB® three times daily for 12 weeks
Outcome: Significant reduction in glycemic control markers including fasting blood glucose, HbA1c, and insulin resistance.
Summary: HIMABERB® berberine effectively lowered glycemic control markers, such as fasting blood sugar and HbA1c, in individuals with prediabetes over 12 weeks, without any severe side effects.
Berberine phospholipid exerts a positive effect on the glycemic profile of overweight subjects with impaired fasting blood glucose (IFG) – Randomised Controlled Trial
Dosage: 2 tablets per day containing 1100 mg of Berberine for two months
Outcome: Improvement in blood sugar levels, cholesterol, triglycerides, insulin levels and reduction in visceral fat and overall fat mass
Summary: This study found that overweight individuals with slightly elevated fasting blood sugar levels who took berberine tablets daily for two months saw significant improvements in their blood sugar, cholesterol levels, and fat distribution, with no adverse effects reported. Berberine proved to be a safe and natural option for managing these conditions.
A Phase I Trial of Berberine in Chinese with Ulcerative Colitis – Randomised Control Trial
Dosage: 900 mg of Berberine daily for 12 weeks
Outcome: Safety of berberine and its effects on colonic tissue inflammation
Summary: This study explored the potential benefits of berberine in ulcerative colitis. It found that berberine, when taken with mesalamine, a standard treatment for ulcerative colitis, was generally safe and helped to reduce inflammation in the colon.
Inhibition of inflammation by berberine: Molecular mechanism and network pharmacology analysis – Systematic Review
Dosage: : Not specified in a single dose; the study focuses on multiple studies conducted between 2013-2023
Outcome: Berberine inhibits inflammatory cytokine production and reduces oxidative stress through pathways like NF-κB and MAPK.
Summary: Berberine helps reduce inflammation by blocking key signalling pathways and enhancing immune regulation.
Efficacy and Safety of Triple Therapy Containing Berberine, Amoxicillin, and Vonoprazan for Helicobacter pylori Initial Treatment – Randomised Controlled Trial
Dosage: Berberine 500 mg twice daily for 2 weeks (in addition to other treatments)
Outcome: Rate of getting rid of Helicobacter pylori (a stomach bacteria)
Summary: The study found that the combination of berberine, amoxicillin, and vonoprazan was just as effective and safe as other common treatments for initially getting rid of harmful stomach bacteria.
A Randomized Clinical Trial of Berberine Hydrochloride in Patients with Diarrhea-Predominant Irritable Bowel Syndrome – Randomised Controlled Trial
Dosage: 400 mg of Berberine Hydrochloride daily, taken twice for 8 weeks
Outcome: Reduction in diarrhoea, abdominal pain, and urgent need for defecation
Summary: This study found that Berberine helped reduce symptoms like diarrhoea and stomach pain in people with a specific type of irritable bowel syndrome. It also improved their quality of life and was safe to take.
Effect of Berberine Hydrochloride on the Diversity of Intestinal Flora in Parkinson’s Disease Patients – Randomised Controlled Trial
Dosage: 600 mg/day of Berberine for 12 weeks, in addition to conventional Parkinson’s disease treatment.
Outcome: Improved intestinal flora diversity and reduced inflammation levels in Parkinson’s disease patients.
Summary: This study showed that adding berberine hydrochloride to standard treatment for Parkinson’s disease helped improve the variety of gut bacteria and lower inflammation markers more effectively than standard treatment alone.
Berberine has been used in traditional medicine for thousands of years worldwide to treat gastrointestinal issues, infections, and metabolic conditions. More recently, it has been studied for its potential blood sugar-regulating benefits and positive effects on the gut microbiome.
Berberine has poor bioavailability on its own. According to this study combining berberine with milk thistle may improve its absorption. Therefore, we’ve included milk thistle to potentially maximise berberine’s bioavailability.
Berberine is thought to work primarily by activating AMPK, an enzyme involved in energy regulation known as the ‘metabolic master switch.’
AMPK acts as an energy sensor in cells. It is naturally activated when cellular energy is low or in high demand, such as through fasting and high-intensity exercise. Once activated, it encourages the cells to uptake glucose (sugar) from the blood, where it can then be converted into energy. It does this by activating insulin receptors, proteins on the cell surface that bind to insulin, a hormone controlling blood glucose levels.
When insulin binds to its receptors on cells, it triggers a series of events that allow glucose to be absorbed into cells for energy. Berberine has been studied for its ability to promote the translocation of GLUT4 (Glucose Transporter Type 4) to the cell surface, enhancing the movement of glucose from the blood into muscle and fat cells.
Berberine also positively impacts the gut microbiome by promoting beneficial bacteria like Bifidobacterium and Lactobacillus while inhibiting harmful strains, including certain strains of Firmicutes and Proteobacteria. This is partly due to Berberine’s antimicrobial properties, which suppress unwanted bacteria and create a balanced microbiome. As an antioxidant, Berberine may also reduce gut inflammation, improving the gut lining and supporting the growth of beneficial bacteria.
Healthy insulin sensitivity allows cells to absorb glucose more effectively, keeping blood sugar levels stable. Over time, factors such as high-sugar diets and sedentary lifestyles lead to insulin resistance, where cells fail to respond correctly to insulin, leading to an accumulation of advanced glycation end-products (AGEs), harmful compounds that accumulate during high blood sugar levels, causing inflammation. Chronic high blood sugar levels also place stress on the beta cells of the pancreas, which produce insulin. Over time, this stress can result in beta cell exhaustion, reducing their ability to produce sufficient insulin. Additionally, inflammation, oxidative stress, and insulin resistance further impair beta cell function.
Insulin resistance and impaired insulin production are precursors to type 2 diabetes and increase the risk of cardiovascular disease. AMPK activation has been shown to improve insulin sensitivity by promoting glucose uptake into cells and enhancing insulin receptor activity. This leads to more efficient glucose use, lowering blood sugar levels and improving the body’s response to insulin.
Chronic high blood sugar and the accumulation of AGEs are linked to age-related decline. AMPK activation is associated with enhanced autophagy, improved insulin sensitivity, and better metabolic health, all of which support healthy ageing. Berberine has been studied for its ability to activate AMPK, helping reduce oxidative stress, inflammation, and cholesterol—factors that influence lifespan and health in later years.
Consider the following statements. If you find one or more relatable, Berberine might be the support you’ve been searching for:
We are committed to the following quality controls to ensure consistency, reliability, and transparency in every product. Our goal is to raise industry standards and give you clear reasons to trust what you’re taking.
All products are made to cGMP (current Good Manufacturing Practice) standards, the global benchmark for supplement quality. GMP standards ensure strict control over how our supplements are produced, covering everything from cleanliness to documentation and quality control. Every step is monitored to guarantee consistency and safety in every batch, so you receive the same high-quality product every time.
Created by the US FDA, GMP regulations legally require manufacturers to ensure product safety, purity, and effectiveness. GMP minimises contamination, mix-ups, and errors, protecting consumers from ineffective or unsafe products.
GMP Guidelines Overview:
At the foundation of what we offer is certainty of product quality through consistent third-party testing, specifically for purity.
In an industry where many supplement providers cannot be fully certain of their product quality, third-party testing is essential to ensure purity and safety. This process removes uncertainty, so you can be confident that you’re taking supplements that are both safe and effective.
Every active ingredient in every batch of vitalityPRO products is independently tested by accredited laboratories to ensure unbiased analysis of purity.
Additional third-party testing screens for contaminants such as heavy metals, pesticides, and microbes, ensuring that each product is safe for consumption. Although certificates are provided by the manufacturer, this independent validation goes beyond standard testing, adding an extra layer of quality control.
Independent third-party testing ensures that you receive reliable, high-quality products every time.
ISO 9001:2015 standards are an internationally recognised framework for effective quality management. This accreditation means we follow a structured system of continuous improvement, always refining our processes to enhance product consistency and customer satisfaction. ISO accreditation ensures that every aspect of our operations—from production to customer service—is optimised. This means better oversight, reduced risk of errors, and a clear focus on delivering consistent results.
ISO 9001:2015 accreditation highlights a commitment to quality, customer satisfaction, and continuous improvement.
We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.
Transparency means we share all the details that matter—how our products are made, tested, and verified. From publishing third-party test results to offering clear ingredient labels, we provide you with the information you need to make informed choices about your supplements. Nothing is hidden, and every product comes with full accountability.
In a world where many supplement companies keep you in the dark, we believe you deserve complete honesty. Being transparent allows you to trust that you’re getting exactly what you expect—pure, tested supplements without hidden risks. It’s about empowering you to make confident decisions and focus on your health journey without second-guessing the products you take.
In several studies, Berberine has shown effects comparable to Metformin in regulating blood sugar, though they work in different ways.
Berberine works by activating AMPK, an energy-sensing enzyme naturally triggered when cellular energy is low. AMPK promotes glucose absorption from the blood into cells for energy, partly by moving glucose transporter proteins to the cell surface.
Metformin, a biguanide drug, primarily reduces glucose production in the liver.
If you are taking Metformin, we encourage you to consult your doctor before making any changes.
Berberine is best taken with each main meal throughout the day for healthy weight and blood sugar management. If you are planning to take it to help you improve the results of a fast, then taking 1000 mg with your last meal of the day is recommended.
Berberine hydrochloride is the most commonly available form of supplemental berberine; unfortunately, it has poor availability. This can be improved with the addition of milk thistle extract. Each capsule of Advanced Berberine contains 500 mg capsule of berberine HCL with 125 mg of milk thistle extract for an effective dosage and to ensure optimal bioavailability.
Studies have indicated that berberine supplementation may be helpful for several gut-related conditions, including the infection Candida.
If you want to use berberine to potentially assist in healing any gut-related issues you are experiencing, we suggest you first speak to your doctor before adding berberine to your gut care protocol.
Because Berberine increases levels of AMPK, the enzyme that activates the fasting process autophagy, it can be used to support a fast. However, berberine should not be taken on an empty stomach, as it may cause blood sugar to become too low.
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