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For sleep support, take 1-3 capsules 20-30 minutes before sleep. If your goal is to increase NAD levels by inhibiting the enzyme CD38, take 2-4 capsules per day before bed.
Apigenin is fat-soluble, meaning it is best absorbed by the body when taken with a fat source. Healthy options for this are avocado, yoghurt, coconut or extra virgin olive oil.
CD38 inhibitors are not recommended when fighting an active infection. CD38 helps regulate immune cell activity and promotes the production of important inflammatory molecules that control and eliminate pathogens.
| Amount Per Capsule | Amount | %NRV |
|---|---|---|
| Apigenin | 100mg | * |
| from Grapefruit Peel, natural source |
Nutrient Reference Value not established*
Suitable for vegans. Contains no GMOs, common allergens, artificial colours, preservatives or flavours.
Date · Batch # · Results
Purity results include Heavy Metals
Previous results:
July 2025 · 2500300
97% Purity and Microbiology
January 2024 · BN12192023
100% Purity and Microbiology
December 2023 · BN12192023
100% Purity and Microbiology
October 2022 · API10202022
98.7% Purity
June 2022 · API06142022
98% Purity
April 2022 · API03172022
98% Purity
Testing is carried out by Certified Labs (formerly Micro Quality Labs).
To maintain the potency and quality of your Apigenin store it in a cool (20°C-25°C), dry place and away from light.
Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015.
Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Micro Quality Labs. You can view all testing certificates at www.vitality-pro.com/batch-testing.
Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.
Interactions: Apigenin is known to interact with members of the Cytochrome P450 class of enzymes. As a result, it may interfere with antiplatelet and anticoagulant medications such as Warfarin and Aspirin. Because Apigenin has sedative properties, it might compound the effects of certain sedating medications such as Diazepam. It has also been shown to interact with certain chemotherapy agents and may interfere with the effectiveness of certain anti-anxiety medications such as Diazepam. In some people, Apgenin may act in a similar way to the hormone Oestrogen and, therefore, interfere with certain hormone replacement therapy interventions. If you are taking these medications or any other medication, please first speak with your doctor before adding Apigenin to your supplement regime.
For further information regarding any other potential drug and supplement interactions with Apigenin, please see the ingredient profile on Drug Bank using the link below.*
Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.
Pregnancy: If pregnant, consult your health professional before using this product.
*Drug Bank is an independent website that lists potential interactions between the ingredients in Apigenin and other medications and supplements. It may not, however, list all known possible interactions. If you are on any medications or supplements you feel may interact negatively with Apigenin please first speak with your doctor before using this product.
Apigenin is a natural flavonoid found in chamomile and parsley. It has been studied for its ability to regulate GABA, a calming brain neurochemical, and inhibit CD38, an enzyme that consumes NAD.
For sleep support, take 1-3 capsules 20-30 minutes before sleep. If your goal is to increase NAD levels by inhibiting the enzyme CD38, take 2-4 capsules per day before bed.
Apigenin is fat-soluble, meaning it is best absorbed by the body when taken with a fat source. Healthy options for this are avocado, yoghurt, coconut or extra virgin olive oil.
CD38 inhibitors are not recommended when fighting an active infection. CD38 helps regulate immune cell activity and promotes the production of important inflammatory molecules that control and eliminate pathogens.
| Amount Per Capsule | Amount | %NRV |
|---|---|---|
| Apigenin | 100mg | * |
| from Grapefruit Peel, natural source |
Nutrient Reference Value not established*
Suitable for vegans. Contains no GMOs, common allergens, artificial colours, preservatives or flavours.
Date · Batch # · Results
Purity results include Heavy Metals
Previous results:
July 2025 · 2500300
97% Purity and Microbiology
January 2024 · BN12192023
100% Purity and Microbiology
December 2023 · BN12192023
100% Purity and Microbiology
October 2022 · API10202022
98.7% Purity
June 2022 · API06142022
98% Purity
April 2022 · API03172022
98% Purity
Testing is carried out by Certified Labs (formerly Micro Quality Labs).
To maintain the potency and quality of your Apigenin store it in a cool (20°C-25°C), dry place and away from light.
Manufacturing: All products are made to GMP standards and have been quality-managed in accordance with the UK standard ISO 9001:2015.
Third-party tested: To ensure the highest purity and maximum effectiveness, each new batch of products undergoes third-party testing by ISO 17025 accreditated Micro Quality Labs. You can view all testing certificates at www.vitality-pro.com/batch-testing.
Do not exceed the recommended daily dose. Food supplements should not replace a varied and balanced diet and a healthy lifestyle. If you are pregnant, breastfeeding, under 18 or taking any medication, consult a doctor before use. Stop use if adverse reactions occur.
Interactions: Apigenin is known to interact with members of the Cytochrome P450 class of enzymes. As a result, it may interfere with antiplatelet and anticoagulant medications such as Warfarin and Aspirin. Because Apigenin has sedative properties, it might compound the effects of certain sedating medications such as Diazepam. It has also been shown to interact with certain chemotherapy agents and may interfere with the effectiveness of certain anti-anxiety medications such as Diazepam. In some people, Apgenin may act in a similar way to the hormone Oestrogen and, therefore, interfere with certain hormone replacement therapy interventions. If you are taking these medications or any other medication, please first speak with your doctor before adding Apigenin to your supplement regime.
For further information regarding any other potential drug and supplement interactions with Apigenin, please see the ingredient profile on Drug Bank using the link below.*
Allergy: This product does not contain any common allergens; however, it should not be used by anyone with a history of hypersensitivity to its ingredients or those taking medications that may interact with it.
Pregnancy: If pregnant, consult your health professional before using this product.
*Drug Bank is an independent website that lists potential interactions between the ingredients in Apigenin and other medications and supplements. It may not, however, list all known possible interactions. If you are on any medications or supplements you feel may interact negatively with Apigenin please first speak with your doctor before using this product.
Orders placed are shipped within 24 hours (Monday to Friday) from the UK.
Need some advice?
Customer Care | +44 (0) 1202 082 280 | support@vitality-pro.com
While individual results may vary due to personal health conditions, genetics, and lifestyle choices, we guarantee that the supplements you receive are made with ingredients of the highest purity, similar to those used in scientific studies, to ensure maximum results.
Apigenin: a natural molecule at the intersection of sleep and aging – Review
Outcome: Apigenin inhibits the enzyme CD38, which helps increase NAD+ levels, a molecule essential for healthy ageing.
Summary: Apigenin inhibits CD38, preventing the consumption of NAD+ in cells, leading to higher NAD+ levels. This mechanism is linked to its potential anti-ageing benefits and improvement of cellular functions related to sleep and longevity.
Apigenin: a natural molecule at the intersection of sleep and aging – Review
Dosage: N/A
Outcome: Improved sleep quality through modulation of molecular pathways such as GABA and inflammation.
Summary: Apigenin, a flavonoid found in chamomile, has shown potential to enhance sleep quality and influence ageing. It works by modulating sleep-related pathways and increasing NAD+ levels, with evidence from both animal and human studies suggesting a positive impact on sleep and mood.
The effects of chamomile extract on sleep quality among elderly people – Randomised Control Trial
Dosage: 200 mg of chamomile extract, twice daily for 28 days
Outcome: Improved sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI)
Summary: Chamomile extract significantly improved sleep quality among elderly participants compared to the control group. This suggests chamomile can be a safe, natural remedy for improving sleep in older adults.
Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NAD CD38 Axis – Cell Study
Dosage: NA
Outcome: Reduced ageing signs in lung cells exposed to stress
Summary: Apigenin showed potential in fighting ageing in lung cells by activating certain pathways that counteract stress and ageing effects, suggesting it could help with lung diseases related to ageing, like COPD.
Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38 – Cell Study and Mouse Study
Dosage: Mixed doses administered in cell cultures and in obese mice
Outcome: Increased NAD+ levels, improved glucose and fat metabolism
Summary: Apigenin inhibits CD38, leading to higher NAD+ levels, which improves cellular health by enhancing metabolic functions.
CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD+/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats – Preclinical Animal study
Dosage: 20 mg/kg for 5 days (animal dose equivalent)
Outcome: Increased NAD+/NADH ratio and Sirt3 activity; reduced kidney damage and oxidative stress in diabetic rats.
Summary: Apigenin, by inhibiting CD38, increases NAD+ levels and Sirt3 activity, helping to reduce kidney damage caused by oxidative stress in diabetic rats with diabetic kidney disease.
Flavonoid Apigenin is an Inhibitor of the NAD+ ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome – Preclinical Animal Study
Dose: 100 mg/kg of body weight (animal dose equivalent)
Outcome: Increased NAD+ levels, reduced protein acetylation, and improved glucose and lipid regulation in obese mice.
Summary: Apigenin inhibits CD38, boosting NAD+ levels, which helps regulate metabolism and could be a potential treatment for metabolic syndrome.
Apigenin is a flavonoid found in plants like chamomile and parsley. It has been used for centuries in traditional remedies for its anti-inflammatory and calming effects, often to reduce anxiety and support digestion. More recently, it has been studied for its role in preserving NAD levels and its potential to improve sleep and reduce oxidative stress.
The enzyme CD38 consumes significant amounts of NAD in its role in immune signalling and inflammatory responses. Apigenin has been identified as a CD38 inhibitor, binding to CD38 and blocking its activity. This action helps control inflammatory responses and preserves NAD levels.
Apigenin supports GABA by binding to GABA receptors, enhancing GABA’s calming effects in the nervous system. This interaction helps enhance GABA’s ability to reduce excessive neuronal firing, leading to a calming effect on the brain, which can promote relaxation and aid sleep.
Some studies have shown that Apigenin can control the NF-kB pathway, which regulates inflammation, by binding to and blocking the activity of an enzyme (IKK) that starts the pathway. This stops NF-kB from entering the cell and activating genes that produce inflammatory molecules.
NAD is essential for cellular energy production, supporting optimal cellular repair and stress response, and activating longevity-related enzymes like sirtuins. However, NAD levels decline with age, stress, poor diet, and metabolic dysfunction. This reduction impacts energy production, accelerates cellular damage, and reduces the body’s ability to repair itself.
Healthy sleep is also essential for overall health. During sleep, the brain consolidates new information, aiding memory and learning, while the body repairs itself. Key hormones like melatonin and growth hormone are released, supporting detoxification, muscle growth, and the production of neurochemicals like dopamine and serotonin. However, modern life disrupts sleep with factors such as blue light, noise, and late-night eating, which increase stress and hinder the production of the neurochemicals needed for restful sleep.
As we age, levels of chemicals that consume NAD increase while the body’s ability to produce NAD declines. By inhibiting the CD38 enzyme, apigenin may help preserve NAD levels necessary for maintaining cellular energy and function with age. Additionally, sleep quality often decreases as we get older. By increasing GABA, a calming neurotransmitter, Apigenin may reduce stress and improve sleep quality, both essential for minimising cellular damage.
Apigenin is formulated to support cellular energy and sleep.
Consider the following statements. If you find one or more relatable, Apigenin might be the product you’ve been searching for:
We are committed to the following quality controls to ensure consistency, reliability, and transparency in every product. Our goal is to raise industry standards and give you clear reasons to trust what you’re taking.
All products are made to cGMP (current Good Manufacturing Practice) standards, the global benchmark for supplement quality. GMP standards ensure strict control over how our supplements are produced, covering everything from cleanliness to documentation and quality control. Every step is monitored to guarantee consistency and safety in every batch, so you receive the same high-quality product every time.
Created by the US FDA, GMP regulations legally require manufacturers to ensure product safety, purity, and effectiveness. GMP minimises contamination, mix-ups, and errors, protecting consumers from ineffective or unsafe products.
GMP Guidelines Overview:
At the foundation of what we offer is certainty of product quality through consistent third-party testing, specifically for purity.
In an industry where many supplement providers cannot be fully certain of their product quality, third-party testing is essential to ensure purity and safety. This process removes uncertainty, so you can be confident that you’re taking supplements that are both safe and effective.
Every active ingredient in every batch of vitalityPRO products is independently tested by accredited laboratories to ensure unbiased analysis of purity.
Additional third-party testing screens for contaminants such as heavy metals, pesticides, and microbes, ensuring that each product is safe for consumption. Although certificates are provided by the manufacturer, this independent validation goes beyond standard testing, adding an extra layer of quality control.
Independent third-party testing ensures that you receive reliable, high-quality products every time.
ISO 9001:2015 standards are an internationally recognised framework for effective quality management. This accreditation means we follow a structured system of continuous improvement, always refining our processes to enhance product consistency and customer satisfaction. ISO accreditation ensures that every aspect of our operations—from production to customer service—is optimised. This means better oversight, reduced risk of errors, and a clear focus on delivering consistent results.
ISO 9001:2015 accreditation highlights a commitment to quality, customer satisfaction, and continuous improvement.
We believe you should have full clarity about what you’re putting in your body and the steps we take to ensure the quality of our supplements. That’s why we are transparent and open about every part of our process.
Transparency means we share all the details that matter—how our products are made, tested, and verified. From publishing third-party test results to offering clear ingredient labels, we provide you with the information you need to make informed choices about your supplements. Nothing is hidden, and every product comes with full accountability.
In a world where many supplement companies keep you in the dark, we believe you deserve complete honesty. Being transparent allows you to trust that you’re getting exactly what you expect—pure, tested supplements without hidden risks. It’s about empowering you to make confident decisions and focus on your health journey without second-guessing the products you take.
Apigenin has been identified as a CD38 inhibitor, binding to CD38 and blocking its activity. The enzyme CD38 consumes significant amounts of NAD in its role in immune signalling and inflammatory responses. This action helps control excessive inflammatory responses and preserves NAD levels.
Your Apigenin product is sourced from natural Grapefruit Peel extract.
Apigenin may improve sleep quality by binding to receptors in the brain that correspond with sleep and sleepiness. Apigenin is found abundantly in chamomile tea, which is believed to explain its similarly sedative effect.
Apigenin is considered safe for daily use over an extended period. However, if taking it for sleep, some individuals may develop a tolerance with prolonged use. We recommend taking a short break every few weeks to maintain maximum efficacy.
Some research suggests that consistent use of apigenin may help lower elevated levels of cortisol. If you are concerned about high cortisol, we suggest that you speak to your doctor before taking apigenin.
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