{"title":"Sirtuin Activator","description":"\u003ch2\u003eActivate longevity genes.\u003c\/h2\u003e\n\u003cp\u003eKnown as the protectors of the genome, Sirtuins play a key role in maintaining healthy cells by regulating activities that promote health and balance while preventing cellular damage. Sirtuins are particularly special because they control key functions believed to drive longevity, such as DNA repair, inflammation reduction, stress response, and cell survival\u003c\/p\u003e\n\u003ch3\u003eProtectors of the genome.\u003c\/h3\u003e\n\u003cp\u003eSirtuins are facilitators of chemical reactions, resulting in adding or removing chemical tags from other molecules in a process known as deacetylation. Through this process, Sirtuins can activate and deactivate various functions and pathways of these molecules.\u003c\/p\u003e\n\u003cp\u003eSirtuin activators are compounds identified for their ability to boost the activity and effectiveness of sirtuins. ‘Activating’ or ‘turning on’ sirtuins can lead to increased DNA repair, improved use of energy and nutrients, maintenance of healthy cell function, and a reduction in inflammation, oxidative stress and other harmful molecules that contribute to cell damage and ageing.\u003c\/p\u003e\n\u003cp\u003eIn mammals, 7 types of sirtuins have been identified, each of which is found in different parts of the cell and performs a unique role. SIRT1, 3 and 6 hold the most interest for human health and longevity.\u003c\/p\u003e\n\u003ch3\u003eSIRT1.\u003c\/h3\u003e\n\u003cp\u003eSIRT1 is found in the nucleus of the cell. SIRT 1 helps to control inflammation, DNA repair and cell survival by regulating the activity of NF-kB and p53.\u003c\/p\u003e\n\u003cp\u003eNF-kB is responsible for inflammation response and can be activated by the immune system (cytokines), harmful molecules known as free radicals, UV radiation and viruses. SIRT1 optimises this inflammation response to ensure it is not overactive in intensity or in time so not to cause unnecessary damage.\u003c\/p\u003e\n\u003cp\u003eSIRT 1 can also control the activity of P53, often referred to as the ‘guardian of the genome.’ When needed, P53 is thought to work by slowing down how quickly cells divide therefore allowing DNA to repair itself. If the damage to the cell is too severe p53 can also force cellular apoptosis, or programmed cell death. This stops the damaged cell from replicating and causing dysfunction in the body.\u003c\/p\u003e\n\u003ch3\u003eSIRT3.\u003c\/h3\u003e\n\u003cp\u003eSIRT3 is found in the mitochondria, a part of the cell that helps generate energy. It has plays a key role in cellular energy production and therefore healthy cell function. When activated, SIRT3 helps control enzymes such as LCAD that break down dietary fats into molecules that the mitochondria can use for energy. SIRT3 also activates the electron transfer chain which is cellular machinery found in the mitochondria that helps with the formation of energy from other sources.\u003c\/p\u003e\n\u003ch3\u003eSIRT6.\u003c\/h3\u003e\n\u003cp\u003eSIRT6 is also found in the nucleus of the cell where it plays a crucial role in helping to repair DNA and telomeres. Specifically, SIRT6 can repair severe double-strand breaks in DNA by recruiting and turning on various molecules such as PARPs. These are a group of proteins that can assist in repairing damaged DNA.\u003c\/p\u003e\n\u003cp\u003eSIRT6 also plays a role in helping to maintain telomere length. Telomeres can be thought of as the ends of DNA, like the plastic tips that cover shoe laces. Over time, as cells divide these telomeres shorten leading to the development of genetic damage. SIRT6 activates telomerase, an enzyme that helps to stabilise telomeres and protect DNA from degradation\u003c\/p\u003e","products":[{"product_id":"trans-resveratrol-powder-100g","title":"Trans Resveratrol Powder","description":"\u003cp\u003eTrans-Resveratrol, in micronised powder form, is an antioxidant also believed to activate sirtuin genes responsible for activities most linked to longevity, such as DNA repair, metabolism, and stress response.\u003c\/p\u003e","brand":"Vitality Pro","offers":[{"title":"30 grams","offer_id":67585952022918,"sku":"TRESP30","price":32.0,"currency_code":"GBP","in_stock":false},{"title":"100 grams","offer_id":67585952055686,"sku":"TRESP100","price":89.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1111\/1212\/6854\/files\/Trans-Resveratrol-Powder-Main.jpg?v=1791447587"},{"product_id":"trans-resveratrol-90","title":"Trans Resveratrol","description":"\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003e\u003cspan\u003eResveratrol is a natural plant compound that acts as an antioxidant and is believed to activate sirtuins, which are responsible for activities linked to longevity, such as DNA repair, stress response, and metabolism.\u003c\/span\u003e\u003c\/p\u003e","brand":"Vitality Pro","offers":[{"title":"90 capsules","offer_id":67585952088454,"sku":"TRES90","price":39.0,"currency_code":"GBP","in_stock":true},{"title":"180 capsule","offer_id":67628640829830,"sku":null,"price":74.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1111\/1212\/6854\/files\/Trans-Resveratrol-Supplement-Main.jpg?v=1791447583"},{"product_id":"advanced-pterostilbene-60","title":"Pterostilbene Advanced","description":"\u003cp\u003ePterostilbene is a natural plant molecule found in blueberries. 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